Photo-induced tungsten-catalyzed cascade synthesis of pyrrolo[2,1-]isoquinoline-1,3-dicarboxylate and its reaction mechanism.

A pyrrolo[2,1-]isoquinoline core structure is prevalent in marine and other natural products. This article describes a tungsten-catalyzed [3+2] cycloaddition aromatization of dihydroisoquinoline ester and maleic anhydride or an acrylate. The photochemical reaction tolerates a range of functional groups such as ester, cyano, ketone, bromide, and alkene.

Difluoromethylated Difunctionalization of Alkenes under Visible Light.

Difluoromethylated compounds usually act as bioisosteres for alcohol functional groups and show unique physicochemical and biological properties. The cyano-difluoromethylation of alkenes using 5-((difluoromethyl)sulfonyl)-1-phenyl-1-tetrazole as a CFH radical difluoromethyl precursor was developed to afford nitriles including a CFH group. A low-cost, stable, easily handled 5-((difluoromethyl)sulfonyl)-1-methyl--tetrazole (DFSMT) was synthesized and applied as the radical CFH reagent.

Slow magnetic relaxation of mononuclear complexes based on uncommon Kramers lanthanide ions Ce, Sm and Yb.

Based on the uncommon Kramers ions Ce, Sm and Yb, complexes [Ce(dppbO)Cl] (1, dppbO = 1,2-bis(diphenylphosphino)benzene dioxide), [Sm(dppbO)Cl] (2) and [Yb(dppbO)Cl]Cl (3) toward single-ion magnets were obtained and fully characterized. Complexes 1 and 2 are isostructural seven-coordinate with distorted geometries between a capped trigonal prism and a capped octahedron, while 3 is six-coordinate with an octahedral geometry. Dynamic magnetic property measurements reveal their field induced slow magnetic relaxation behaviours.

TMPO-AS1 Regulates the Aggressiveness-Associated Traits of Nasopharyngeal Carcinoma Cells Through Sponging miR-320a.

Background: Previous evidence demonstrates that the long non-coding RNA (lncRNA) TMPO antisense RNA 1 (TMPO-AS1) is involved in the aggressiveness of several cancers. Nevertheless, its functions in nasopharyngeal carcinoma (NPC) are unclear.

Methods: qRT-PCR was used to evaluate the levels of TMPO-AS1 and miR-320a in NPC tissues.