Fabrication of Cu(I)-Functionalized MIL-101(Cr) for Adsorptive Desulfurization: Low-Temperature Controllable Conversion of Cu(II) via Vapor-Induced Reduction.

Because of their nontoxicity, economic applicability, and excellent performance on adsorptive desulfurization, the fabrication of Cu(I) sites onto porous supports has drawn much attention. However, high temperatures (usually ≥700 °C) are required for the formation of Cu(I) sites from Cu(II) species through the traditional autoreduction method, which is unworkable for thermolabile metal-organic frameworks (MOFs). Here, we report a strategy named vapor-induced reduction (VIR) to convert Cu(II) species to Cu(I) in MIL-101(Cr), in which ethanol is used as an environmentally benign reductant.

[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model].

Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed.

Generation of Hierarchical Porosity in Metal-Organic Frameworks by the Modulation of Cation Valence.

Hierarchically porous metal-organic frameworks (HP-MOFs) have attracted great attention owing to their advantages over microporous MOFs in some applications. Despite many attempts, the development of a facile approach to generate HP-MOFs remains a challenge. Herein we develop a new strategy, namely the modulation of cation valence, to create hierarchical porosity in MOFs.

Targeted discovery and identification of novel nucleoside biomarkers in Apostichopus japonicus viscera using metabonomics.

In this study, we investigated the metabonomic profiles of Apostichopus japonicus using an LC-MS-based method in conjunction with multivariate data analysis. Based on the PLS-DA model, 85 differential metabolites (VIP value >1.0) were obtained from viscera and body wall samples.

Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish.

Marsdenia tenacissima exhibits biological activity with heat-clearing and detoxifying properties, relieving coughs and asthma and exerting anticancer and anti-HIV effects. Tenacissioside H (TH) is a Chinese medicine monomer extracted from the dried stem of Marsdenia tenacissima. We investigated the in vivo anti-inflammatory activity of TH using three different zebrafish inflammation models: local inflammation induced by tail cutting, acute inflammation induced by CuSO and systemic inflammation induced by lipopolysaccharide (LPS).

Rational design of thermo-responsive adsorbents: demand-oriented active sites for the adsorption of dyes.

A smart adsorbent RA@MS is fabricated by incorporating a di-block copolymer through the combination of the thermo-responsive block poly(N-isopropylacrylamide) (R) and the active block poly{N-[3-(dimethylamino) propyl]methacrylamide} (A, tertiary amines as basic sites) into mesoporous silica. The di-block copolymer RA preserves the thermo-responsive nature, which makes the active sites reversibly exposed/blocked in light of temperature variation. The obtained adsorbent possessing thermo-responsive properties can thus realize both selective adsorption and efficient regeneration for temperature-swing adsorption (TSA) of dyes.

Controlled Construction of Supported Cu Sites and Their Stabilization in MIL-100(Fe): Efficient Adsorbents for Benzothiophene Capture.

Cu-containing materials have drawn much attention in various applications because they are versatile, nontoxic, and low-cost. However, the difficulty of selective reduction and the poor stability of Cu species are now pretty much the agendas. Here, controlled construction of supported Cu sites in MIL-100(Fe) was realized under mild conditions (200 °C, 5 h) via a vapor-reduction strategy (VRS).

Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32.

Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model.

[Chemical constituents of Kadsura oblongifolia and evaluation of their toxicity].

To study the chemical constituents of K. oblongifolia, silica gel column chromatography, MCI and Sephadex LH-20 were used to separate the 70% acetone extract of the stems of K. oblongifolia.

Chemical constituents of Euphorbia tibetica and their biological activities.

Aim: To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica.

Method: Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay.

Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities.

Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.

Chemical constituents of Excoecaria acerifolia and their bioactivities.

A new kaurane diterpenoid, 3alpha,18-dihydroxy-3beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay.

Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.

We synthesized a series of novel small molecules, 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives, by tandem reduction-oxirane opening of 2-nitroaroxymethyloxiranes in moderate or excellent yields. We investigated the effects of all of the compounds on HUVEC apoptosis and A549 cell growth. The results showed that 6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine was the most effective small molecule in promoting HUVEC apoptosis and inhibiting A549 cell proliferation, but 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine could remarkably inhibit HUVEC apoptosis and might induce the formation of microvessel.