Publications by authors named "Qiu-Shi Gao"
Neural Regen Res
June 2021
Article Synopsis
- Previous research indicates that sevoflurane postconditioning offers neuroprotective benefits and enhances learning and memory in newborn rats following brain injury due to lack of oxygen.
- In an experiment using the Rice-Vannucci model, rats treated with sevoflurane showed improved cognitive functions and reduced brain damage effects such as astrogliosis and glial scars.
- The mechanism behind these effects involves changes in protein expressions, particularly decreased hypoxia-inducible factor-1α and increased DJ-1, suggesting sevoflurane helps stabilize brain function post-injury.
Cell Mol Neurobiol
November 2021
Article Synopsis
- Microglia/macrophages show different polarization patterns after ischemic events, which can influence recovery based on the disease context; this study focuses on how sevoflurane post-conditioning affects these immune cells following hypoxic-ischemic brain injury (HIBI) in neonatal rats.
- Using a HIBI model, researchers examined the impact of sevoflurane on microglial/macrophage polarization and identified mechanisms linked to autophagy and the enzyme cathepsin B, analyzing various cell markers to assess neuroprotection and neuronal health.
- Results indicated that sevoflurane treatment reduced inflammatory markers and neuronal cell death after HIBI, leading to improved long-term cognitive outcomes
Drug Des Devel Ther
January 2020
Article Synopsis
- The study examines the effects of sevoflurane post-conditioning (SPC) on hypoxic-ischemic brain injury (HIBI) in neonatal rats, focusing on autophagy's role and the Ezh2-regulated Pten/Akt/mTOR pathway.
- Inhibition of excessive autophagy was found to provide neuroprotection, as evidenced by improved neuronal density and morphology following SPC treatment.
- The research concluded that SPC protects against HIBI by modulating the Pten/Akt/mTOR signaling pathway through Ezh2, which helps reduce over-activated autophagy in the hippocampus.
