[Biosynthetic pathways of Polygonatum cyrtonema polysaccharide and diosgenin based on its transcriptomic data].

Polygonatum cyrtonema belongs to the plant family Liliaceae, and its dried rhizome is one of the sources of Chinese traditional medicine of Polygonati Rhizoma. It possesses the dual function as both medicine and food. Its main chemical components are polysaccharides and saponins.

Establishment of cohesion 1 homolog 2 facilitates cell aggressive behaviors and induces poor prognosis in renal cell carcinoma.

Background And Aims: Establishment of cohesion 1 homolog 2 (ESCO2) has been identified as an essential factor for cohesion in cell cycle in human multiple cancers. Nonetheless, its functional implication on prognosis and cellular behaviors of renal cell carcinoma (RCC) is rarely elucidated. We performed this study to detect the effects of ESCO2 in RCC progression.

PYCR1 is Associated with Papillary Renal Cell Carcinoma Progression.

Objective: We aimed to determine the function of pyrroline-5-carboxylate reductase 1 (PYCR1) on progression of papillary renal cell carcinoma (PRCC) and related mechanism.

Methods: The TCGA database provided us expression profiles of PYCR1 and overall survival rates. Small interfering RNA (siRNA) was used to knockdown PYCR1; quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were conducted to identify the expression levels of mRNA and protein.

A Case Report of Primary Neonatal Hypocholinesterase Caused by Homozygous Frameshift Mutation of the utyrylcholinesterase (BCHE) Gene and Review of Literature.

Background: Primary neonatal hypocholinesterase is rare; its genetic pattern and mutation still need to be further studied.

Methods: The patient and his parents are studied using next-generation sequencing technology.

Results: A boy one day after birth is admitted to the Neonatal Intensive Care Unit at our hospital after experiencing intermittent vomiting for 12 hours.

Study on serum Tau protein level and neurodevelopmental outcome of placental abruption with neonatal hypoxic-ischemic encephalopathy.

The aim of this study was to explore differences in serum Tau protein levels and neurodevelopmental prognoses of placental abruption or umbilical cord around neck with hypoxic-ischemic encephalopathy (HIE). Forty neonates with moderate/severe HIE divided into placental abruption with HIE group (placental abruption with hypoxic-ischemic encephalopathy (PA-HIE) group) ( = 18) and umbilical cord around the neck with HIE group (umbilical cord around the neck with hypoxic-ischemic encephalopathy (UCAN-HIE) group) ( = 22). Healthy term newborns comprised the control group ( = 35).

SATB2-Associated Syndrome: a Case Report of a De Novo Nonsense Mutation in SATB2 from China and Review of Literature.

Background: To study the clinical and genetic features from a Chinese child with SATB2-associated syndrome (SAS) and review of literature.

Methods: The girl, 2 years 3 months old, is admitted to the Department of Pediatric Rehabilitation in our hospital. This patient has mental retardation, language development disorder, cleft palate II0, micrognathia, malocclusion, irritability and bilateral oblique palpebral fissure as a clinical manifestation and is treated for 3 months.

Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy.

Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy, many neonatal patients die or suffer from severe neurological dysfunction. Erythropoietin is considered one of the most promising neuroprotective agents. We hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy treatment.

Predictive Value of Neurodevelopmental Outcome and Serum Tau Protein Level in Neonates with Hypoxic Ischemic Encephalopathy.

Background: Tau protein is s specific protein expressed by neurons in the central nervous system. Elevated serum Tau protein is associated with many diseases of the central nervous system. The serum Tau protein level in neonates with hypoxic ischemic encephalopathy (HIE) is still poorly understood.

[Interaction models of cucurbit (n=6,7,8) urils and imidazo[4,5,f]1,10-phenanthroline derivates].

The interaction structures and optical properties of host-guest of cucurbit[n=6-8]urils with synthesized three imidazo-[4,5, f]1,10-phenathroline derivates were investigated by using 1HNMR technique, fluorescence spectrophotometry, and ultraviolet spectrophotometry. The experimental results reveal that cucurbit [6] uril (Q[6]) can only interact with guest salt of 2-(4-methyl)-phenyl-imidazo-[4,5,f]1,10-phenathroline (W1) with a ratio of 1:1; however, cucurbit [7] uril (Q[7]) can interact with all three guest salts of 2-(4-methylphenyl)-imidazo-[4,5,f]1,10-phenathroline(W1), 2-(2-methylphenyl)-imidazo-[4,5,f] 1,10-phenathroline(W2), and 2-(3-methyloxyl phenyl)-imidazo-[4,5,f]1,10-phenathroline(W3) with the same ratio of 1:1; cucurbit [8] uril (Q[8]), except interaction with W1 with a ratio of 1:2, can also interact with W2 and W3 with a ratio of 1:1.