Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations.

This work aims to investigate how the bile acid metabolism of newborns differs from that of adults along the axis of primary, secondary, and tertiary bile acids (BAs). The total unconjugated BA profiles were quantitatively determined by enzyme digestion techniques in urine of 21 newborns born by cesarean section, 29 healthy parturient women, 30 healthy males, and 28 healthy nonpregnant females. As expected, because of a lack of developed gut microbiota, newborns exhibited poor metabolism of secondary BAs.

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity.

The primary bile acids (BAs) synthesized from cholesterol in the liver are converted to secondary BAs by gut microbiota. It was recently disclosed that the major secondary BA, deoxycholate (DCA) species, is stereoselectively oxidized to tertiary BAs exclusively by CYP3A enzymes. This work subsequently investigated the in vitro oxidation kinetics of DCA at C-1, C-3, C-4, C-5, C-6, C-6, and C-19 in recombinant CYP3A enzymes and naive enzymes in human liver microsomes (HLMs).

Past occupational dust exposure, depressive symptoms and anxiety in retired Chinese factory workers: the Guangzhou Biobank Cohort Study.

Objective: Few studies have systematically investigated the impact of past occupational dust exposure on mental health. We examined whether retired factory workers exposed to any of the 4 dusts of silica, cement, coal and asbestos had more depressive symptoms and anxiety in southern China, which has experienced rapid economic development.

Methods: We used data from the Guangzhou Biobank Cohort Study phase 3.

[Analysis of influential factors for job burnout among managers in a joint venture in Guangzhou, China].

Objective: To investigate the influential factors for job burnout among the managerial staff in a Sino-Japanese joint venture automobile manufacturer in Guangzhou, China.

Methods: A total of 288 managers in a Sino-Japanese joint venture automobile manufacturer were surveyed using the Occupational Stress Indicator, Maslach Burnout Inventory (MBI), Eysenck Personality Questionnaire, Simplified Coping Style Questionnaire, and Social Support Rating Scale.

Results: On the depersonalization dimension, the male managers had significantly higher scores than the female managers.

The relationship between occupational stress, burnout, and turnover intention among managerial staff from a Sino-Japanese joint venture in Guangzhou, China.

Objective: The aim of this study was to analyze the associations between occupational stress, burnout and turnover intention and explore their associated factors among managerial staff in Guangzhou, China.

Methods: This cross-sectional study recruited 288 managerial employees from a Sino-Japanese joint venture automobile manufacturing enterprise in Guangzhou. The questionnaire included questions about sociodemographic characteristics, smoking, drinking and physical activity and the Chinese versio ns of the Occupational Stress Indicator (OSI), Maslach Burnout Inventory (MBI), Eysenck Personality Questionnaire (EPQ), Simplified Coping Style Questionnaire (SCSQ) and Social Support Rating Scale (SSRS).

[Epidemiological study of occupational diseases in Guangzhou City, China in 2001 - 2010].

Objective: To analyze the epidemiological characteristics of occupational diseases in Guangzhou City, China in 2001 - 2010, and to provide a scientific basis for the prevention and control of occupational diseases.

Methods: Statistical analysis was performed on the reported data on the occupational diseases in Guangzhou from 2001 to 2010.

Results: A total of 380 cases of occupational diseases (37 types,8 classes) were diagnosed and reported in 2001 - 2010.

[Influential factors on psychosocial health of the migrant workers in Guangzhou].

Objective: To study the influential factors on psychosocial health of the migrant workers in Guangzhou.

Methods: The Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ) were used to investigate 518 migrant workers in Guangzhou.

Results: The rate of migrant workers with psychosocial problems was 36.

[Personality and occupation stress of workers in processing line in Guangzhou].

Objective: To study relationships between personality and occupational stress of workers in processing line in Guangzhou.

Methods: 452 workers in processing line in Guangzhou were investigated by the Eysenck Personality Questionnaire (EPQ) and Occupational Stress Indicator (OSI).

Results: N scores and P scores of EPQ were positively correlated with the occupational stress and the poor physical fitness status (r value was 0.

[Analysis of the situation of occupational health surveillance and the morbidity of occupational diseases in Guangzhou].

Objective: To analyze the situation of occupational health surveillance and the characteristics of occupational diseases in Guangzhou.

Methods: The situation of occupational health surveillance and the morbidity of occupational diseases were studied retrospectively by use of the physical examination data collected from the labour hygienic reports of the city from 1993 to 2002. The data were divided into two groups: the first group from 1993 to 1997, and the second from 1998 to 2002.