Publications by authors named "Qiu-Geng Ouyang"
Article Synopsis
- The study investigates systemic RNA oxidative damage during infections caused by a specific pathogen, focusing on the changes in blood cells and inflammatory responses in a rat model of acute intestinal infection.
- Findings reveal that the infection leads to significant increases in various immune markers and cytokines, and notably, urinary levels of 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which indicate RNA oxidation.
- The results suggest that urinary 8-oxo-Gsn could serve as a promising biomarker for determining the severity and outlook of infections caused by this pathogen, as levels return to normal upon recovery.
Effects of 27 CYP3A4 protein variants on saxagliptin metabolism in vitro.
Fundam Clin Pharmacol
February 2022
Saxagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor widely used in patients with type 2 diabetes. It can increase the amount of insulin after meals and lower blood sugar. CYP450 3A4 (CYP3A4) can metabolize about 30%-40% of therapeutic drugs.
View Article and Find Full Text PDFMore and more evidence support the concept that RNA oxidation plays a substantial role in the progress of multiple diseases; however, only a few studies have reported RNA oxidation caused by microbial pathogens. Urinary 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn), which are broadly used as indicators of oxidative damage of RNA and DNA, were analyzed in this study to determine which can be used as a biomarker of infection in challenged with (). In this work, 24 specific-pathogen-free (SPF) male SD rats were randomly divided into two groups: an infection group and a phosphate-buffered saline (PBS) control group.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the roles of MTH1 and NUDT5 proteins in esophageal squamous carcinoma (ESCC), discovering that their upregulation is linked to worse patient outcomes and prognosis.
- Using techniques like immunohistochemistry and Western blotting, researchers found that higher levels of MTH1 and NUDT5 correlate with lower overall survival rates in ESCC patients.
- Experiments showed that knocking out MTH1 and NUDT5 in ESCC cells significantly hindered cell proliferation and altered the cell cycle, suggesting their critical role in tumor growth and progression.
Background: Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug-drug interactions.
Materials And Methods: Given statins have the possibility of combination with lidocaine in the clinic, we established in vitro models to assess the effect of statins on the metabolism of lidocaine.
The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro.
Infect Drug Resist
November 2018
Background: CYP/CYP450 2C19 (CYP2C19) is a highly polymorphic enzyme and exhibits individual differences in metabolic activity. The purpose of this research was mainly to explore the catalytic activities of 30 CYP2C19 variants on the substrate voriconazole in vitro, including 24 novel CYP2C19 variants (2C19.2E-.
View Article and Find Full Text PDFInhibitory effect of resveratrol on the pharmacokinetic of ibrutinib by UPLC-MS/MS.
Drug Dev Ind Pharm
January 2019
Objective: To investigate the impact of resveratrol on the metabolism of ibrutinib in vitro and in vivo.
Methods: In vitro, rat liver microsomes (RLM) and human liver microsomes (HLM) were used to study. In vivo, 18 male SD rats were randomly divided into three groups (n = 6): ibrutinib and the multiple dose of 100 mg/kg resveratrol for consecutive 7 days (Group A), ibrutinib and the single dose of 100 mg/kg resveratrol (Group B), ibrutinib (Group C).
Objective: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo.
Method: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or without genistein.