Publications by authors named "Qiu-Fang Qin"
Liver cancer is one of the most common malignant tumors, with the death rate ranking fourth among all types of cancer. Over the past few decades, several studies have reported that liver tumorigenesis is associated with dysfunction in autophagy. However, the detailed mechanism remains unclear.
View Article and Find Full Text PDFEthnopharmacological Relevance: Gynura procumbens is applied topically for the treatment of traumatic injuries in South China.
Materials And Methods: This study was conducted to identify the active ingredients in the essential oils from Gynura procumbens (GPEO) by Gas Chromatography-Mass Spectrometer (GC-MS) and to elucidate the mechanisms underlying the anti-inflammatory and antinociceptive effects in vivo and in vitro.
Results: A reduction in dswelling and pain were observed in mice treated with GPEO or its active ingredients (α-pinene, 3-carene, and limonene) compared with mice treated with a solvent control.
Extract of the Blood Circulation-Promoting Recipe (EBR-84) from the Chinese Herbal medicine "Blood Circulation Promoting Recipe" could retard retinopathy development. This study investigated whether EBR-84 protects retinas by inhibiting the β-catenin pathway using a rat model of retinopathy and a retinal ganglion cell 5 (RGC-5) cell death model. RGC death was induced by either -methyl-d-aspartic acid (NMDA) or TWS119 (an activator of the β-catenin pathway).
View Article and Find Full Text PDFArticle Synopsis
- The study explored the effects of excessive fish oil and omega-3 fatty acids on intestinal tight junctions and Kupffer cell polarization in a mouse model simulating alcoholic steatohepatitis (ASH) through a diet supplemented with ethanol and fish oil.
- After multiple instances of binge drinking, the mice exhibited liver damage characterized by steatosis, necrosis, inflammation, and fibrosis.
- Results indicated that high doses of fish oil negatively impacted intestinal health and led to an imbalance in Kupffer cell polarization, increasing harmful M1 cells while decreasing beneficial M2 cells, thus worsening the gut-liver connection in alcohol-induced liver disease.