Publications by authors named "Qiu Xuan Li"
Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy is largely affected by the low quality of MSCs collected from patients. Here, we showed that the gene expression of MSCs from patients with diabetes was differentially regulated compared to that of MSCs from healthy controls.
View Article and Find Full Text PDFObjective: To determine the association of serum complement C1q levels with cardiovascular outcomes among patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), and evaluate the value of C1q modified by high-sensitivity C-reactive protein (hs-CRP) levels as an independent predictor.
Methods: As a single-center prospective observational study, we analyzed 1701 patients who had received primary or elective PCI for ACS at Beijing Anzhen Hospital, Capital Medical University, Beijing, China between June 1, 2016 and November 30, 2017. The associations of C1q modified by hs-CRP with major adverse cardiovascular events (MACE) were determined in survival analysis.
Background: The net clinical benefit of antithrombotic therapy (ATT) reflects the concomitant effects of bleeding and ischemic events.
Objectives: We sought to assess the overall effect of the modulation or escalation of ATT on all-cause mortality as well as ischemic and bleeding events.
Methods: We performed a meta-analysis of randomized controlled trials comparing escalation or modulation of ATT versus standard ATT in patients with coronary artery disease.
Background: Triglyceride (TG) and its related metabolic indices, all recognized as surrogates of insulin resistance, have been demonstrated to be relevant to clinical prognosis. However, the relative value of these TG-related indices for predicting cardiovascular events among patients with acute coronary syndrome (ACS) has not been examined.
Methods: The TG, the triglyceride-glucose (TyG) index, the atherogenic index of plasma, TG to high-density lipoprotein cholesterol ratio, and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary intervention.
Background: Homeostasis of thyroid hormones has significant effects on the cardiovascular system. The aim of this study was to investigate the association between free triiodothyronine (FT3) and adverse cardiovascular events in patients with acute coronary syndrome (ACS) who were undergoing percutaneous coronary intervention (PCI).
Methods: A total of 1701 patients with ACS undergoing PCI were included in this study.
Article Synopsis
- The study investigated how elevated Remnant Cholesterol (RC) levels are linked to poor cardiovascular outcomes in acute coronary syndrome (ACS) patients, both with and without diabetes.
- Data from 1,716 ACS patients showed that those with RC levels above 0.79 mmol/L had a significantly higher risk of experiencing major adverse cardiovascular events (MACE) during a median follow-up of 927 days.
- The findings suggest that while high RC is a risk factor for MACE in all ACS patients, its prognostic importance is particularly pronounced in diabetic patients.
Malnutrition has been shown to be associated with adverse cardiovascular outcomes in many patient populations. To investigate the prognostic significance of malnutrition as defined by nutritional risk index (NRI) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and whether NRI could improve the GRACE score based prognostic models. This study applied NRI among 1,718 patients with ACS undergoing PCI.
View Article and Find Full Text PDFArticle Synopsis
- Norovirus (NoV) is a contagious virus that causes diarrhea in humans and animals, with recent outbreaks posing significant public health threats and economic challenges.
- The emergence of a new recombinant strain, GII.P16-GII.2, has raised concerns about its high infectivity and potential for pandemic spread, highlighting the urgent need for vaccine development.
- Research showed that vaccine-like particles (VLPs) from the GII.P16-GII.2 strain induced strong immune responses in mice, specifically affecting macrophages and CD4+ T cells, which is crucial for understanding immune reactions and advancing vaccine strategies.
GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH.
Front Endocrinol (Lausanne)
February 2022
GLP-1 is derived from intestinal L cells, which takes effect through binding to GLP-1R and is inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). However, GLP-1 possesses broader pharmacological effects including anti-inflammation, neuro-protection, regulating blood pressure (BP), and reducing lipotoxicity.
View Article and Find Full Text PDFA chemical study on the stems and leaves of resulted in the isolation and identification of a new monoterpenoid indole alkaloid, melodicochine A (), together with seven known monoterpenoid indole alkaloids (-). The chemical structure of was elucidated on the basis of extensive spectral data analyses and the known compounds were identified by comparing their experimental spectral data with the reported data in the literature. All isolated indole alkaloids were evaluated for their neuroprotective effects against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells .
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