Green preparation of highly transparent nano-NH-UiO(Zr)-66/cellulose composite films with high-strength, superior flame retardant and UV to high-energy blue light shielding performance.

From the perspective of sustainable development and practical applications, there is a significant demand for the design of advanced cellulose-based film materials with superior mechanical, optical, and functional properties utilizing environmentally friendly strategies. Herein, biodegradable, mechanically robust and flame-retardant cellulose films with adjustable optical performance were successfully fabricated by in situ synthesis of NH-UiO(Zr)-66 via a DMF-free green process at room temperature. The results indicate that the introduction of NH-UiO(Zr)-66 enables films to realize a desirable flame retardancy (the limiting oxygen index (LOI) increased significantly from 19.

Seeking materials from nature for interrupting eye damage: Ultraviolet to blue light blocking clear cellulose films enabled by curcumin.

The harms caused by ultraviolet (UV) and blue light to eyes are attracting momentous concern due to growing exposure to artificial illumination and modern IT devices. Herein, a simple and eco-friendly adsorption approach was employed to integrate curcumin, a natural bioactive compound, into the cellulose substrate for the development of flexible and biodegradable filters capable of blocking harmful light. The curcumin/cellulose films demonstrate excellent UV-screening competence and photostability, with UV-A and UV-B screening ratios ranging from 92.

Copper-based metal halides for X-ray and photodetection.

Copper-based metal halides have become important materials in the field of X-ray and photodetection due to their excellent optical properties, good environmental stability and low toxicity. This review presents the progress of research on crystal structure/morphology, photophysics/optical properties and applications of copper-based metal halides. We also discuss the challenges of copper-based metal halides with a perspective of their future research directions.

Three-stimulus control ultrasensitive Dirac point modulator using an electromagnetically induced transparency-like terahertz metasurface with graphene.

This letter presents a fabricated Dirac point modulator of a graphene-based terahertz electromagnetically induced transparency (EIT)-like metasurface (GrE & MS). Dynamic modulation is realized by applying three stimulus modes of optical pump, bias voltage, and optical pump-bias voltage combination. With increasing luminous flux or bias voltage, the transmission amplitude undergoes two stages: increasing and decreasing, because the graphene Fermi level shifts between the valence band, Dirac point, and conduction band.

Bioinspired asymmetric amphiphilic surface for triboelectric enhanced efficient water harvesting.

The effective acquisition of clean water from atmospheric water offers a potential sustainable solution for increasing global water and energy shortages. In this study, an asymmetric amphiphilic surface incorporating self-driven triboelectric adsorption was developed to obtain clean water from the atmosphere. Inspired by cactus spines and beetle elytra, the asymmetric amphiphilic surface was constructed by synthesizing amphiphilic cellulose ester coatings followed by coating on laser-engraved spines of fluorinated ethylene propylene.

Spheres Multiple Physical Network-Based Triboelectric Materials for Self-Powered Contactless Sensing.

Non-contact mode triboelectric nanogenerators effectively avoid physical contact between two triboelectric materials and achieve long-term reliable operation, providing broad application prospects in the field of self-powered sensing. However, the low surface charge density of triboelectric materials restricts application of contactless sensing. Herein, by controlling Rayleigh Instability deformation of the spinning jet and vapor-induced phase separation during electrostatic spinning, a polyvinylidene fluoride@Mxene (Ti C T ) composite film with spheres multiple physical network structures is prepared and utilized as the triboelectric material of a self-powered contactless sensor.

Analysis of graphene-based tunable THz four-band absorption sensors.

A novel, to the best of our knowledge, four-band tunable absorber sensor, based on a graphene layer, is presented. The proposed sensor configuration is composed of a single monolayer of graphene placed on top of a dielectric substrate, whereas a gold grounding plane is placed beneath the . In addition, the resonant frequencies of the sensor can be directly controlled by adjusting the Fermi level of graphene, while the absorption rate reaches a value greater than 99% at all resonant peaks.

Iron-Rich Conditions Induce OmpA and Virulence Changes of .

Iron ions affect the expression of outer membrane protein A (OmpA), a major pathogenic protein in To analyze the effect of iron ions on the expression of the OmpA protein of and explore its association with the virulence of OmpA. Site-directed mutagenesis was used to construct gene deletion strains and gene repair strains. The OmpA protein expression of under culture with different contents of iron ions was detected.

Effect of acceptance and commitment therapy on rehabilitation patients with spinal cord injury.

This study aimed to explore the differences between the effectiveness of using a combination of rehabilitation and acceptance commitment therapy (ACT), and rehabilitation therapy alone for the treatment of spinal cord injury (SCI). The newly admitted patients with spinal cord injury whose post-traumatic stress disorder (PTSD) score was higher than 38 points were randomly categorized into the treatment group and control group, with 30 patients in each group. One group underwent ACT and rehabilitation treatment, while the other underwent rehabilitation treatment only.

Improved Capture and Removal Efficiency of Gaseous Acetaldehyde by a Self-Powered Photocatalytic System with an External Electric Field.

Using clean and sustainable stochastic energy from the environment to eliminate pollution caused by gaseous aldehydes would be an effective strategy to achieve the sustainable development of energy and preserve the environment. Here, a piston-based triboelectric nanogenerator (P-TENG) was used to enhance gaseous acetaldehyde absorption and photocatalytic degradation. An external electric field could be generated on a conductive substrate by the P-TENG, converting wind energy into electricity.

Hepatectomy for spontaneous rupture of hepatocellular carcinoma without portal triad clamping.

Hepatectomy without portal triad clamping may decrease the incidence of liver injury; however, the effects of hepatectomy without portal triad clamping in the treatment of spontaneous rupture of hepatocellular carcinoma (SRHCC) remain unclear. The aims of the present study were to evaluate the therapeutic value of hepatectomy without portal triad clamping in the treatment of patients with SRHCC. The present study retrospectively reviewed patients with SRHCC who received hepatectomy without portal triad clamping (non-clamping group) and the therapeutic efficacy was compared with that of 20 patients with SRHCC undergoing the same surgery in the presence of portal triad clamping (clamping group).

Noninvasive Imaging of Stored Red Blood Cell-Transfusion Aggravating Sepsis-Induced Liver Injury Associated with Increased Activation of M1-Polarized Kupffer Cells.

Liver injury has a critical effect on the severity and outcome of sepsis. The impact of stored red blood cells (RBCs) on the pathogenesis of sepsis-associated hepatic injury is not well understood. Therefore, to investigate the effects of stored-RBC transfusion on sepsis-induced liver damage as well as the associated mechanism, we constructed a sepsis mouse model enabling noninvasive imaging of bacterial infection caused by Pseudomonas aeruginosa, a common gram-negative respiratory pathogen.

TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells.

Transmembrane 4 superfamily member 1 (TM4SF1) is a member of tetraspanin family, which mediates signal transduction events regulating cell development, activation, growth and motility. Our previous studies showed that TM4SF1 is highly expressed in liver cancer. HepG2 cells were transfected with TM4SFl siRNA and TM4SF1-expressing plasmids and their biological functions were analyzed in vitro and in vivo.

Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases.

Endotoxin tolerance protects the host by limiting excessive 'cytokine storm' during sepsis, but compromises the ability to counteract infections in septic shock survivors. It reprograms Toll-like receptor (TLR) 4 responses by attenuating the expression of proinflammatory cytokines without suppressing anti-inflammatory and antimicrobial mediators, but the mechanisms of reprogramming remain unclear. In this study, we demonstrate that the induction of endotoxin tolerance in human monocytes, THP-1 and MonoMac-6 cells inhibited lipopolysaccharide (LPS)-mediated phosphorylation of Lyn, c-Src and their recruitment to TLR4, but increased total protein phosphatase (PP) activity and the expression of protein tyrosine phosphatase (PTP) 1B, PP2A, PTP nonreceptor type (PTPN) 22 and mitogen-activated protein kinase phosphatase (MKP)-1.

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.

Development of endotoxin tolerance in macrophages during sepsis reprograms Toll-like receptor 4 signaling to inhibit proinflammatory cytokines without suppressing anti-inflammatory and antimicrobial mediators and protects the host from excessive inflammation and tissue damage. However, endotoxin tolerance renders septic patients immunocompromised and unable to control secondary infections. Although previous studies have revealed the importance of several negative regulators of Toll-like receptor signaling in endotoxin tolerance, the role of Pellino proteins has not been addressed.

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, and TANK-binding kinase (TBK) 1 as critical hallmarks of endotoxin tolerance, but mechanisms remain unclear. In this study, we examined the role of the E3 ubiquitin ligase Pellino-1 in endotoxin tolerance and TLR signaling.

Polyinosinic-cytidylic acid as an adjuvant on natural killer- and dendritic cell-mediated antitumor activities.

Previously, we demonstrated that treatment with E7(44-62) and the adjuvant polyinosinic-cytidylic acid (poly(I:C)) in a rodent model generates antitumor immune responses, but the effect of E7(44-62) with poly(I:C) on natural killer (NK)- and dendritic cell (DC)-mediated antitumor activities is still unclear. Our goal was to examine the antitumor effects of E7(44-62) with poly(I:C). We examined the ability of E7(44-62) with poly(I:C) to induce toll-like receptor 3 (TLR3) expression, tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) mRNA expression, and tumor cell-killing activity in human NK cells as well as its ability to induce CD11c and CD86 expression and proliferation in human DCs.

The antitumor effect of the toll-like receptor 3 ligand polyinosinic-cytidylic acid as an adjuvant.

Although polyinosinic-polycytidylic acid (poly(I:C)) has been applied in tumor immunity as a Toll-like receptor 3 (TLR3) ligand, the interaction between poly(I:C) and TLR3 is still unclear, as are the mechanisms underlying the antitumor effect of poly(I:C). Our aim was to investigate the interaction between poly(I:C) and TLR3, as well as the mechanisms underlying the antitumor effect of poly(I:C). NK92 cells were maintained in medium (untreated group), or medium containing E7(44-62) (E7 group) or E7(44-62)+poly(I:C) (poly(I:C)/E7 group), and we measured the expression of TLR3 mRNA, p-p65, and IκB-α protein.

Protective effect of low-molecular-weight heparin on pancreatic encephalopathy in severe acute pancreatic rats.

Background And Aims: Pancreatic encephalopathy (PE) is a severe complication and significant cause of death in patients with severe acute pancreatitis (SAP). We have reported previously that low-molecular-weight heparin (LMWH) treatment could reduce incidence of PE in SAP patients. Our objective here was to investigate the protective effect of LMWH and its mechanism on PE in SAP rats.

Combined detection of mRNA expression of Alpha-fetoprotein in peripheral blood and telomerase activity of monocytes in hepatocellular carcinoma patients.

Background/aims: The detection of hepatocellular carcinoma (HCC) cells in the peripheral blood is not only important for the diagnosis of FICC, but is also of critical importance for early detection of hematogenous metastasis of HCC. The purpose of this study was to measure Alpha-fetoprotein (AFP) mRNA in the peripheral blood and telomerase activity in peripheral blood monocytes to determine their utility, in isolation and concert, in the early diagnosis of HCC.

Methodology: Nested RT-PCR was employed to detect the mRNA expression of AFP in the peripheral blood, and PCR-ELISA was used to measure the telomerase activity of peripheral blood mononuclear cells (PBMCs) in patients with HCC, benign hepatic tumors, chronic liver diseases and healthy subjects.

Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray.

Background: Hepatocellular carcinoma (HCC) is a common primary cancer frequently associated with hepatitis B virus (HBV) infection. However, whether these identified genes are particularly associated with HBV-related HCC remains unknown. The aim of this study was to investigate the differential gene expression between HBV-related HCC tissues and adjacent noncancerous tissues.

Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.

Endotoxin tolerance reprograms Toll-like receptor 4 responses by impairing LPS-elicited production of pro-inflammatory cytokines without inhibiting expression of anti-inflammatory or anti-microbial mediators. In septic patients, Toll-like receptor tolerance is thought to underlie decreased pro-inflammatory cytokine expression in response to LPS and increased incidence of microbial infections. The impact of endotoxin tolerance on recruitment, post-translational modifications and signalosome assembly of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, TNF receptor-associated factor (TRAF) 6, TGF-β-activated kinase (TAK) 1, and IκB kinase (IKK) γ is largely unknown.

Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors.

Macrophages and natural killer (NK) cells are important antitumor effectors by virtue of their ability to produce cytokines, chemokines and interferons (IFNs) and to mediate tumor cytotoxicity. Little is known about the impact of Toll-like receptor (TLR) and nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) pathways on NK cell functions, and the role of TLRs and NLRs in macrophage activation is incompletely understood. In this study, we examined the capacities of expressed TLRs and NLRs to elicit cytokine production in human NK cells and THP1 macrophages, and to activate NK cytotoxicity against the squamous cell carcinoma of head and neck cell line Tu167 and erythroleukemia K562 cells.