Publications by authors named "Qitian Chen"
Background: Targeted therapy and immunotherapy has brought new hope to patients with lung adenocarcinoma (LUAD) with their applications. However, the prognosis of LUAD patients is still unpromising.
Objective: It is particularly important to find the biomarkers that can predict the prognosis of LUAD.
Article Synopsis
- - The study investigates the use of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics to predict lymphovascular invasion (LVI) in invasive breast cancer patients, focusing on features from different phases of DCE-MRI.
- - A retrospective analysis of 173 breast cancer patients was conducted, with data split into training and validation sets, leading to the creation of models based on various MRI phases and a combined multiphases radiomics nomogram for assessing LVI risk.
- - Key predictors identified included axillary lymph node status and Ki-67 levels, with various models evaluated for predictive performance using statistical methods including receiver operating characteristic (ROC) curves and decision curve analysis (DCA).
Article Synopsis
- The study aims to determine how effectively preoperative MRI-based radiomic features can predict lymphovascular invasion (LVI) in breast cancer patients.
- A thorough search of multiple databases identified eight studies that included a total of 1685 female patients, assessing diagnostic accuracy using histopathology as a standard.
- The results showed a high overall diagnostic odds ratio and sensitivity for MRI radiomics in detecting LVI, as well as variations in performance based on study design and participant characteristics, indicating the potential for improved diagnostic capability when using certain techniques and larger sample sizes.
Objective: The ability of glutathione S-transferase zeta 1 (GSTZ1) to modulate homeostasis of cellular redox and induce ferroptosis was explored in bladder cancer cells, and the involvement of the high mobility group protein 1/glutathione peroxidase 4 (HMGB1/GPX4) in these effects was studied.
Methods: BIU-87 cells stably overexpressing GSTZ1 were transfected with appropriate plasmids to deplete HMGB1 or overexpress GPX4, then treated with deferoxamine and ferrostatin-1. Antiproliferative effects were assessed by quantifying levels of ferroptosis markers, such as iron, glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), GPX4, transferrin, and ferritin.
Cisplatin is a common chemotherapeutic drug for treating ovarian cancer, but its clinical efficacy is hampered by intrinsic and acquired resistance. Previous studies had shown inhibiting oxidative phosphorylation overcomes cisplatin resistance in ovarian cancer. Studies reveal that bedaquiline, a clinically available antimicrobial drug, inhibits cancer via targeting mitochondria.
View Article and Find Full Text PDFBackground: Diffuse large B cell lymphoma (DLBCL) is a more common non-Hodgkin lymphoma (NHL). This study aims to explore the prognostic value of PIM kinase family in DLBCL and its relationship with the immune microenvironment, to provide a certain reference for the prognosis and treatment of DLBCL.
Methods: The prognostic value of PIM kinase family in DLBCL from the data set GSE10846 was verified through survival analysis and cox regression analysis.
Purpose: Cuproptosis-related long non-coding RNA (lncRNA) diseases are associated with the occurrence and development of tumors. This study aimed to investigate whether cuproptosis-related lncRNA can predict the prognosis of patients with lung adenocarcinoma (LUAD).
Methods: Cuproptosis-related lncRNA prognosis (CLPS) model was successfully constructed through cox regression and lasso regression analyses.
Inhibitory effect of endostar combined with radiotherapy on gastric cancer animal models.
World J Surg Oncol
July 2020
Background: Inhibitory effect of endostar combined with radiotherapy on gastric cancer (GC) animal models and its effect on transforming growth factor-β1 (TGF-β1) and inter-leukin-10 (IL-10) were evaluated.
Methods: Forty mice of GC model xenograft tumors were prepared and randomly divided into blank control group, endostar group, radiotherapy group, and endostar combined with radiotherapy group (combination group). From the 14th day, a vernier caliper was used for measuring the long and short diameters of the xenograft tumors.
Clinical efficacy of apatinib in treating metastatic gastric cancer and its effect on the levels of serum IL-17 were investigated. A retrospective analysis was performed on 129 patients who had metastatic gastric cancer after first-line chemotherapy and were treated in Xiangyang No. 1 People's Hospital from February 2012 to February 2015.
View Article and Find Full Text PDFThe role of DNA damage repair and Chk2 protein in hyper-radiosensitivity of lung adenocarcinoma A549 cells.
J Huazhong Univ Sci Technolog Med Sci
October 2012
To explore the role of the Chk2 protein expression and DNA double strand breaks (DSBs) repair in low dose hyper-radiosensitivity (HRS)/increased radioresistance (IRR) of non-small cell lung cancer, A549 cells were subjected to irradiation at the dosage ranging from 0.05-2 Gy. Clonogenic survival was measured by using fluorescence-activated cell sorting (FACS) plating technique.
View Article and Find Full Text PDF