Publications by authors named "Qishuo Zhong"
Article Synopsis
- Ceramides, a type of sphingolipid, can self-assemble into adaptable protein channels, a trait that is underexplored in artificial ion channels.
- A new class of artificial channels, called Pn-TPPs, made from PEGylated cholic acids with triphenylphosphonium groups, can form chloride ion channels at low concentrations and nanopores at high concentrations.
- These Pn-TPPs selectively target mitochondria in cancer cells, triggering apoptosis while showing promising anticancer effects, particularly with P5-TPP demonstrating significant activity against liver cancer cells, outperforming doxorubicin in selectivity.
Non-Covalently Stapled H /Cl Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy.
Angew Chem Int Ed Engl
January 2024
The development of stimuli-responsive artificial H /Cl ion channels, capable of specifically disturbing the intracellular ion homeostasis of cancer cells, presents an intriguing opportunity for achieving high selectivity in cancer therapy. Herein, we describe a novel family of non-covalently stapled self-assembled artificial channels activatable by biocompatible visible light at 442 nm, which enables the co-transport of H /Cl across the membrane with H /Cl transport selectivity of 6.0.
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