Self-immunological disease aid diagnosis with ConvSANet and Eu-clidean distance.

Background: Ankylosing spondylitis (AS), Osteoarthritis (OA), and Sjögren's syndrome (SS) are three prevalent autoimmune diseases. If left untreated, which can lead to severe joint damage and greatly limit mobility. Once the disease worsens, patients may face the risk of long-term disability, and in severe cases, even life-threatening consequences.

Identification of novel risk factors for postoperative severe hypocalcemia in patients with primary hyperparathyroidism undergoing parathyroidectomy: a case control study.

Background: Patients with primary hyperparathyroidism (PHPT) are at risk for severe hypocalcemia (SH) following parathyroidectomy (PTX), but limited data exist on the predictors of SH. We aimed to identify risk factors for early postoperative SH after PTX in patients with PHPT and to evaluate the predictive value of clinical parameters.

Methods: A retrospective review of patients with PHPT who underwent PTX between January 2010 and December 2022 was performed.

MS-Net: a novel lightweight and precise model for plant disease identification.

The rapid development of image processing technology and the improvement of computing power in recent years have made deep learning one of the main methods for plant disease identification. Currently, many neural network models have shown better performance in plant disease identification. Typically, the performance improvement of the model needs to be achieved by increasing the depth of the network.

High-precision bladder cancer diagnosis method: 2D Raman spectrum figures based on maintenance technology combined with automatic weighted feature fusion network.

Background: Raman spectroscopy has been extensively utilized as a marker-free detection method in the complementary diagnosis of cancer. Multivariate statistical classification analysis is frequently employed for Raman spectral data classification. Nevertheless, traditional multivariate statistical classification analysis performs poorly when analyzing large samples and multicategory spectral data.

Effects of WeChat platform-based continuing care on self-management and quality of life in patients with arthritis: A quasi-experimental study.

Objective: To assess the effects of WeChat platform-based continuing care for arthritis on patients' self-management, self-efficiency, quality of life (QoL), and medication compliance.

Methods: A study was conducted on arthritis patients recruited between December 2017 and February 2018 and divided into two groups. The intervention group received continuing care from the WeChat platform and regular follow-ups, while the control group only received regular follow-ups.

TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing.

Introduction: Gastric cancer is a well-known malignant tumor that causes millions of deaths worldwide every year. Due to the lack of a specific biomarker for gastric cancer, most patients are diagnosed at an advanced stage of the disease which results in a poor prognosis and a higher death rate. Therefore, novel biomarkers are urgently needed for early diagnosis and to improve the survival rate.

Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis.

Background: Endometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment.

Methods: A retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted.

A polyoxometalate-based heterojunction nanozyme with peroxidase-mimic catalytic activity for sensitive biomolecule detection.

Nanozymes are a class of nanomaterials that can specifically mimic the structures and catalytic activities as well as overcome limitations of natural enzymes and have hence been considered as a competitive alternative to natural enzymes. At present, plenty of nanozymes, especially those with peroxidase (POD)-like catalytic activity, have been extensively explored for biosensing. In this work, we proposed polyoxometalate-based heterojunction GdPWO@WS nanoclusters (NCs) to exert intrinsic POD-like catalytic activity even under harsh catalytic conditions.

A novel full solar light spectrum responsive antimicrobial agent of WS quantum dots for photocatalytic wound healing therapy.

Photocatalytic antimicrobial therapy (PCAT) is considered to be a potential therapeutic treatment for bacterial-infection diseases. However, the antibacterial efficiency is unsatisfactory due to the limited application scope of photocatalysis. In this work, full-spectrum responsive tungsten disulfide quantum dots (WS QDs) are prepared for killing bacteria and enabling wound healing through photocatalytic reactive oxygen species (ROS) generation and glutathione (GSH) depletion.

AuNPs@MoSe heterostructure as a highly efficient coreaction accelerator of electrocheluminescence for amplified immunosensing of DNA methylation.

Electrocheluminescence analysis amplified by coreaction accelerators has experienced breakthrough in ultrasensitive detection of biomarkers. Herein, a highly efficient coreaction accelerator, two-dimensional layered MoSe nanosheets loaded with gold nanoparticles (AuNPs@MoSe heterostructure), is proposed to enhance the ECL efficiency of Ru(bpy)/tripropylamine (TPrA) system. The presence of AuNPs avoids the aggregation of MoSe nanosheets, and improves the electrical conductivity of modified surface.

Electrochemiluminescence of Polymer Dots Featuring Thermally Activated Delayed Fluorescence for Sensitive DNA Methylation Detection.

Polymer dots (Pdots) as electrochemiluminescence (ECL) emitters have drawn intensive attention for expanding the application of ECL analytical technology. Here we used a donor-acceptor polymer with thermally activated delayed fluorescence (TADF) property as a precursor to design and synthesize a kind of highly efficient Pdots with desirable annihilation and co-reactant ECL behaviors. The TADF Pdots possessed a highly stable negative-charged state in the ECL process, and their ECL emission followed the "S-route", thus achieving theoretically 100% excitons harvesting for radiative decay.

Patulinervones A and B, two novel -glucosidase inhibitory -lignans from (Merr. & Chun) C.C. Huang.

(±)-Patulinervones A () and B (), two diastereomers of -lignans sharing an unprecedented dimethyl-[furan-2,2'-furo[2,3-]furan] 5/5/5 tricyclic moiety were isolated from the leaves of (Merr. & Chun) C.C.

Tumor microenvironment-activated single-atom platinum nanozyme with HO self-supplement and O-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy.

Nanozyme-based tumor collaborative catalytic therapy has attracted a great deal of attention in recent years. However, their cooperative outcome remains a great challenge due to the unique characteristics of tumor microenvironment (TME), such as insufficient endogenous hydrogen peroxide (HO) level, hypoxia, and overexpressed intracellular glutathione (GSH). Herein, a TME-activated atomic-level engineered PtNC single-atom nanozyme (PtNC-SAzyme) is fabricated to induce the "butterfly effect" of reactive oxygen species (ROS) through facilitating intracellular HO cycle accumulation and GSH deprivation as well as X-ray deposition for ROS-involving CDT and O-dependent chemoradiotherapy.

Retraction notice to "The cytoprotective effects of Δ-17 fatty acid desaturase on injured HUVECs and its underlying mechanism" [Saudi Pharm. J. 25(4) (2017) 587-594].

[This retracts the article DOI: 10.1016/j.jsps.

SOX17-mediated MALAT1-miR-199a-HIF1α axis confers sensitivity in esophageal squamous cell carcinoma cells to radiotherapy.

Radiotherapy is a main modality of esophageal squamous cell carcinoma (ESCC) treatment, while radioresistance largely limits the effect of this therapy. Evidence exists reporting that SOX17 may sensitize ESCC cells to irradiation, but the downstream mechanism remains poorly understood. Therefore, we attempt to explore the molecular basis of SOX17 effect on radioresistance in ESCC.

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of PLOD2.

Some previous studies have shown that has some value in tumorigenesis. However, the broad significance of has not been discussed in depth. This study was aimed at elaborated and summarized the value of PLOD2 in various tumors.

Changes in Bone Mineral Density After Parathyroidectomy and Their Relations With Biochemical Markers of Bone Metabolism.

Background: To measure total type 1 serum amino-terminal propeptide procollagen (t-P1NP), β- type 1 cross-linked C-terminal telopeptide collagen (β-CTX), N-terminal osteocalcin (OC), and 25-(OH)-VD3 levels before parathyroidectomy (PTX) in patients with PHPT, and correlate these measurements with bone mineral density (BMD) changes at 1-year post-PTX.

Methods: Patients with primary hyperparathyroidism (PHPT) were followed from diagnosis to 12 months after surgery. Serum levels of calcium, parathyroid hormone (PTH), vitamin 25-(OH)-VD3, OC, β-CTX, t-P1NP, and BMD were measured before and 1 year after surgery.

Risk factors for twin pregnancy in women undergoing double cleavage embryo transfer.

Background: Two or more embryo transfers have been used to increase the success rate of live birth in traditional in vitro fertilization (IVF) strategy at the expense of increased risks of multiple pregnancy and adverse perinatal outcomes. The decision regarding the elective single embryo transfer or double embryo transfer remains inconclusive. The aim of this study was to investigate the risk factors for twin pregnancy in IVF.

Influence of Label Design and Country of Origin Information in Wines on Consumers' Visual, Sensory, and Emotional Responses.

This study aimed to evaluate the influence of origin information on Pinot Noir wine labels using eye-tracking and its associations with purchase intent, and hedonic and subconscious emotional responses. Two studies were carried out on untrained university staff and students aged 20-60 years old. Study 1 was conducted to assess consumers' ( = 55; 55% males, and 45% females) self-reported and subconscious responses towards four design labels (with and without New Zealand origin name/script or origin logo) using eye-tracking and video analysis to evaluate emotions of participants.

The effect of low-dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: A randomised, placebo-controlled trial.

Background: Low-dose ketamine has been proved to reduce opioid consumption, prevent depressant action and improve postoperative analgesia. Women undergoing mastectomy experience may not only have persistent postoperative pain syndromes but also emotional problems. However, the effect of intraoperative infusion of low-dose ketamine on postoperative quality of recovery among these patients has not yet been fully studied.

A Biofilm Microenvironment-Activated Single-Atom Iron Nanozyme with NIR-Controllable Nanocatalytic Activities for Synergetic Bacteria-Infected Wound Therapy.

Biofilm microenvironment (BME)-activated antimicrobial agents display great potential for improved biofilm-related infection therapy because of their superior specificities and sensitivities, effective eliminations, and minimal side effects. Herein, BME-activated Fe-doped polydiaminopyridine nanofusiform-mediated single-atom nanozyme (FePN SAzyme) is presented for photothermal/chemodynamic synergetic bacteria-infected wound therapy. The photothermal therapy (PTT) function of SAzyme can be specifically initiated by the high level of H O and further accelerated through mild acid within the inflammatory environment through "two-step rocket launching-like" process.

Apigenin Inhibits the Histamine-Induced Proliferation of Ovarian Cancer Cells by Downregulating ERα/ERβ Expression.

Background: Apigenin (APG), a natural flavonoid, can affect the development of a variety of tumors, but its role in ovarian cancer remains unclear. There has been an increasing amount of evidence supporting the vital role played by mast cells and the bioactive mediators they release, as components of the tumor microenvironment, in the progression of ovarian cancer (OC); however, the mechanism warrants further exploration.

Methods And Results: In this study, a combination of transcriptomics analysis and application of TCGA database was performed, and we found that the expression of genes related to mast cell degranulation in ovarian cancer tissues changed remarkably.

Age Influences the Prognosis of Anaplastic Thyroid Cancer Patients.

Background: The staging system for patients with anaplastic thyroid cancer (ATC) was updated in the 8 edition of the American Joint Committee on Cancer Staging Manual. A cut-off age of 55 years was stipulated as a prognostic factor for differentiated thyroid cancer; however, age was not considered for ATC patients. To this end, this study investigated the relationship between age at diagnosis and prognosis of ATC patients.

Fe-Based Single-Atom Nanozyme with Superior Peroxidase-Mimicking Activity for Enhanced Ultrasensitive Biosensing.

Nanomaterials with intrinsic enzyme-mimicking characteristics, refered to as nanozymes, have become a hot research topic owing to their unique advantages of comparative low cost, high stability and large-scale preparation. Among them, Single-atom nanozymes (SAzymes), as novel nanozymes with abundant atomically dispersed active sites, have caused specific attention in the development of nanozymes for their remarkable catalytic activities, maximum atomic utilization and excellent selectivity, the homogeneous catalytic sites and clear catalytic mechanisms. Herein, a novel single-atom nanozyme based on Fe(III)-doped polydiaminopyridine nanofusiforms (Fe-PDAP SAzyme) was successfully proposed via facile oxidation polymerization strategy.