Prediction Trough Concentrations of Valproic Acid Among Chinese Adult Patients with Epilepsy Using Machine Learning Techniques.

Objective: This study aimed to establish an optimal model based on machine learning (ML) to predict Valproic acid (VPA) trough concentrations in Chinese adult epilepsy patients.

Methods: A single-center retrospective study was carried out at the Jinshan Hospital affiliated with Fudan University from January 2022 to December 2023. A total of 102 VPA trough concentrations were split into a derivation cohort and a validation cohort at a ratio of 8:2.