The Efficacy of Denosumab in Patients With Rheumatoid Arthritis: A Systematic Review and Pooled Analysis of Randomized or Matched Data.

Objective: The purpose of this study was to evaluate the efficacy of denosumab treatment in patients with rheumatoid arthritis (RA).

Methods: The Medline, Embase and Cochrane Library databases were searched for relevant clinical studies. Studies that assessed the efficacy of denosumab in patients with RA were identified.

In-situ detection of cadmium with aptamer functionalized gold nanoparticles based on smartphone-based colorimetric system.

Cadmium is a heavy metal pollutant in environment with high toxicity that severely threats human health. A simple and sensitive method for rapid detection of cadmium ions in water sample is of significant importance. In this paper, a colorimetric method based on aptamer-functionalized gold nanoparticles (AuNPs) for specific recognition were proposed to realize Cd detection.

Sex-related differences in catheter ablation of atrial fibrillation: a systematic review and meta-analysis.

Aims: The sex-related differences in the clinical outcomes of rhythm and safety after catheter ablation remain unclear. The purpose of this study was to compare the clinical outcomes of catheter ablation for atrial fibrillation (AF) in women and men.

Methods And Results: The Medline and EMBASE databases were searched for published articles up to December 2018.

Graphene FET Array Biosensor Based on ssDNA Aptamer for Ultrasensitive Hg Detection in Environmental Pollutants.

Invisible mercury ion is an extremely poisonous environmental pollutant, therefore, a fast and highly sensitive detection method is of significant importance. In this study, a liquid-gated graphene field-effect transistor (GFET) array biosensor (6 × 6 GFETs on the chip) was fabricated and applied for Hg quantitate detection based on single-stranded DNA (ssDNA) aptamer. The biosensor showed outstanding selectivity to Hg in mixed solutions containing various metal ions.

Interleukin-10-1082 G/a polymorphism and acute renal graft rejection: a meta-analysis.

Objective: The aim of this study was to investigate the association between interleukin (IL)-10-1082 (G/A) promoter polymorphism and acute rejection (AR) in renal transplant recipients.

Methods: We searched MEDLINE, EMBASE, Web of Science, and Cochrane Central Register from the inception to March 2015 for relevant studies. Data concerning publication information, population characteristics, and transplant information were extracted.

Preoperative statin therapy decreases early mortality in patients undergoing isolated valve surgery: result from a meta-analysis.

Objective: The purpose of this meta-analysis was to assess the role of preoperative statin therapy on adverse cardiovascular events in patients undergoing valve surgery.

Design: Meta-analysis of 10 observational studies.

Setting: Hospital.

Sequencing analysis and characterization of the plasmid pBIF10 isolated from Bifidobacterium longum.

A resident plasmid, pBIF10, was isolated from Bifidobacterium longum B200304, and the full-length sequence of pBIF10 was analyzed. In this sequence, we identified at least 17 major open reading frames longer than 200 bp. A tetracycline resistance gene, tetQ, was identified and verified to confer antibiotic resistance to tetracycline.

The long-term efficacy of cryoballoon vs irrigated radiofrequency ablation for the treatment of atrial fibrillation: A meta-analysis.

Objectives: The main purpose of this meta-analysis was to compare the long-term efficacy of cryoballoon ablation (CBA) with irrigated radiofrequency catheter ablation (RFCA) for the treatment of atrial fibrillation (AF).

Methods: The Medline, Cochrane Library and Embase Database were searched for clinical studies published up to October 2014. Studies that fulfilled our predefined inclusion criteria were included.

[Enterotoxigenic Escherichia coli heat-labile enterotoxin B subunit can efficiently induce and enhance the mucosal immune response to enterovirus 71].

Objective: To detect the immunogenicity of enterotoxigenic Escherichia coli heat-labile enterotoxin B subunit (LTB) and evaluate the immune effect of enterovirus 71 (EV71) capsid protein VP1 together with LTB by the intranasal route.

Methods: The LTB gene was cloned into the plasmid pET32a. The 6×His-LTB fusion protein was purified with Ni(2+)-NTA resin and used to vaccinate the New Zealand white rabbits to prepare the LTB-specific antiserum.

Meta-analysis of the effects of preoperative renin-angiotensin system inhibitor therapy on major adverse cardiac events in patients undergoing cardiac surgery.

The purpose of this meta-analysis was to assess the role of preoperative renin-angiotensin system inhibitor (RASI) therapy on major adverse cardiac events (MACE) in patients undergoing cardiac surgery. The Medline, Cochrane Library and Embase databases were searched for clinical studies published up to May 2014. Studies that evaluated the effects of preoperative RASI therapy in cardiac surgery were included.

Bevacizumab in the treatment of pterygium: a meta-analysis.

Purpose: The aim of this study was to assess the efficacy and safety of bevacizumab in the treatment of pterygium and to mainly explore its effects on recurrence rate and complications.

Methods: We searched MEDLINE, EMBASE, Web of Science, and Cochrane Central Register from the inception to July 2013 for relevant randomized controlled trials that examined bevacizumab therapy for pterygium. Data concerning study design, patient characteristics, treatment, and outcomes were extracted.