Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA.

Snakebite envenomation often leads to severe visceral injuries, including acute liver injury (ALI). However, the toxicity mechanism remains unclear. Moreover, varespladib can directly inhibit phospholipase A (PLA) in snake venom, but its protective effect on snakebite-induced ALI and the mechanism have not been clarified.

A317491 relieved HIV gp120-associated neuropathic pain involved in P2X receptor in dorsal root ganglia.

Glycoprotein 120 (gp120) is an HIV envelope glycoprotein. Gp120 can directly stimulate the primary sensory afferent neurons and cause hyperalgesia. The P2X receptor in dorsal root ganglia (DRG) is involved in the transmission of pain.

Ontogenic expression profiles and oxaliplatin regulation of leptin expression in mice dorsal root ganglion.

Leptin is widely distributed in many tissues, including the nervous system. However, the ontogeny of leptin expression in the dorsal root ganglion (DRG) is unclear. Recent studies have shown that leptin is involved in the regulation of neuropathic pain induced by nerve injury.