Difference in hematocrit and plasma albumin levels as an early biomarker of severity and prognosis in patients with severe fever and thrombocytopenia syndrome.

Severe fever with thrombocytopenia syndrome (SFTS) is a widespread infectious disease with high mortality. Hence, identifying valuable biomarkers for detecting the early changes in SFTS is crucial. In this study, we investigated the relationship between the difference in hematocrit (HCT) and serum albumin (ALB) levels (HCT-ALB) and the prognosis of patients with SFTS virus infection.

Epidemiological and Clinical Characteristics of Severe Fever with Thrombocytopenia Syndrome in Southern Anhui Province, China, 2011-2020.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever, and the causative pathogen, the SFTS virus (SFTSV), was first discovered in China in 2010. In this study, a retrospective analysis of 86 patients that were diagnosed with SFTS from two 5-year periods (2011-2015 and 2016-2020) was performed to explore the changes in epidemiology, clinical characteristics, laboratory parameters, and prognosis between both periods. The results showed that there were significant differences in age, the proportion of farmers, geographical distribution, the incidence of multiple organ dysfunction, the decrease in thrombocyte count, and the elevations of serum AST and lipase levels between the two groups (P < 0.

Autophagy inhibition by reversine and its suppressive effects on human hepatocellular carcinoma cells.

Introduction: Therapy for human hepatocellular carcinoma (HCC) remains a great challenge for physicians and patients worldwide. The anti-tumor effects of reversine have attracted much more concerns.

Materials And Methods: This study evaluated the growth regulatory effects of reversine on HCC cells lines.