Cuttlefish Ink Tagged Photonic Crystal Particles and Their Ion-Responsive Construction.

Colloidal crystal materials have potential values in coding, sensing, displaying and so on. Attempts to promote these values tend to focus on the development of functional colloidal crystal materials with high color saturations and bright structural colors for practical applications. Thus, this work presented novel cuttlefish ink nanoparticles doped colloidal crystal particle material, which had distinguishable and high saturation colors, and could response to the electric field and pH obviously.

eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells.

The roles of microRNA in regulation of various biological processes and in modulation of therapeutic effects have been widely appreciated. In this study, we found a positive correlation between miR-449 b expression and radiation sensitivity in cancer cells and in tumor specimens from patients. We showed that eEF-2 kinase, a negative regulator of global protein synthesis, is a target of miR-449 b.

Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol.

In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear protein of the BTB/POZ gene family, has pivotal roles in cancer development. Here, we identified that NAC1-PDK3 axis as necessary for suppression of mitochondrial function, oxygen consumption, and more harmful ROS generation and protects cancer cells from apoptosis in hypoxia.

Responsive photonic barcodes for sensitive multiplex bioassay.

Barcodes have a demonstrated value for multiplex high-throughput bioassays. The tendency of this technology is to pursue high sensitivity target screening. Herein, we presented a new type of inverse opal-structured poly(N-isopropylacrylamide) (pNIPAM) hydrogel photonic crystal (PhC) barcodes with the function of fluorescent signal self-amplification for the detection.

Boronate affinity molecularly imprinted inverse opal particles for multiple label-free bioassays.

Boronate affinity molecularly imprinted polymer inverse opal particles were developed for the multiplex label-free detection of glycoproteins with high sensitivity and specificity.