Publications by authors named "Qiongchao Zou"
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease, and this study aimed to explore the link between various serum metabolites and IPF using Mendelian randomization (MR) analysis.
- Researchers analyzed 824 serum metabolites and discovered 12 that were associated with IPF, identifying both risk factors and protective factors among them.
- The study revealed specific metabolites, such as certain lipids and amino acids, that could influence the risk of developing IPF, with implications for understanding the disease's mechanisms and potential treatments.
Background: The immune system plays a vital role in the pathophysiology of acute myocardial infarction (AMI). However, the exact immune related mechanism is still unclear. This research study aimed to identify key immune-related genes involved in AMI.
View Article and Find Full Text PDFThe present study aimed to investigate the regulatory mechanism of chemokine (C-X-C motif) receptor 4 (CXCR4) on endothelial progenitor cells (EPCs) through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway under hypoxic conditions. Mononuclear cells were isolated from the bone marrow (BM) of young Sprague-Dawley (SD) rats. Bone marrow-derived endothelial progenitor cells (BM-EPCs) were characterized by using Dil-labeled acetylated low-density lipoprotein (Dil-ac-LDL) and fluorescein isothiocyanate-labeled UEA (FITC-UEA-1).
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- MicroRNAs (like miR-520d) help control cell processes and can be important in heart problems like atrial fibrillation (AF).
- The study found that when heart cells are stimulated quickly, a protein called ADAM10 increases while miR-520d decreases, which affects cell health.
- Boosting miR-520d or reducing ADAM10 helps heart cells live better and reduces cell death in this rapid-pacing scenario.
Myocardial ischemia/reperfusion (IR) injury is one of the most prevalent cardiovascular diseases, known for its high mortality and morbidity worldwide. Based on pre-existing evidence, LGALS3 has been found to be closely associated with cardiac diseases. Hence, the objective of our study is to explore the potential function of KCNQ1OT1/microRNA-204-5p (miR-204-5p)/ LGALS3 axis on myocardial IR injury and the underlying mechanism.
View Article and Find Full Text PDFmicroRNAs (miRs) are essential in the development of heart failure. The aim of this study is to investigate the effect of microRNA-330 (miR-330) on left ventricular remodeling via the TGF-β1/Smad3 signaling pathway by targeting the sex-determining region Y (SRY) in mice with myocardial ischemia-reperfusion injury (MIRI). Differentially expressed gene (DEG) in myocardial ischemia-reperfusion (IR) was screened out and the miR that targeted the DEG was also predicted and verified.
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