Publications by authors named "Qiong-Zhen Yuan"

Retinal degenerative diseases were a large group of diseases characterized by the primary death of retinal ganglion cells (RGCs). Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasomes, which may affect RGCs in retinal degenerative diseases. The NLRP3 inflammasome was a protein complex that, upon activation, produces caspase-1, mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative diseases.

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Article Synopsis
  • The study investigates the impact of the NLRP3/autophagy pathway on inflammation in photoreceptors, focusing on the protective effects of CY-09 and astaxanthin (AST).
  • ICR mice were divided into five groups and treated with different combinations of NaIO, CY-09, and AST; various assays were used to measure cell viability, apoptosis, and levels of inflammation-related proteins.
  • Results indicate that both CY-09 and AST reduce inflammation and cell death in photoreceptors while inhibiting the NLRP3/autophagy pathway, suggesting they could offer protection against retinal inflammatory damage.
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