Publications by authors named "Qiong-Tao Wang"
Article Synopsis
- Gestational diabetes mellitus (GDM) affects pregnancy by inhibiting the invasion of trophoblast cells, which may lead to complications; however, the reasons behind the aging (senescence) of these cells in GDM are not yet fully understood.
- Researchers studied ARID1A expression in GDM placental tissues and found that higher levels of ARID1A led to decreased cell proliferation and increased senescence of trophoblast cells, particularly under high glucose conditions.
- The study suggests that ARID1A recruits another protein, GATA2, to regulate the transcription of CDKN1A, highlighting a potential target for developing diagnostic and therapeutic approaches for managing GDM.
Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation in rats with AF. Gene ontology and pathway enrichment analyses were used to identify the possible function of miR-10a in cardiac fibrosis. The results showed that overexpressed miR-10a significantly prolonged the duration of AF, further elevated the collagen volume fraction (CVF), and increased the viability of CFs in AF rats; these findings were in contrast with the findings for rats with inhibition of miR-10a (all <0.
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