Publications by authors named "Qiong-Lian Fang"
Article Synopsis
- The study investigates the effects of SA, a plant extract from southwestern China, on the gut microbiota and metabolic regulation in rats with non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD).
- SA treatment significantly reduced body weight, lipid levels, and inflammation while inhibiting various inflammatory markers related to the NLRP3 signaling pathway.
- Analysis demonstrated that SA improved gut microbiota diversity and altered microbial composition, identifying 24 key metabolites that may play a role in restoring metabolic balance in NASH rats.
Article Synopsis
- - Tylophora yunnanensis Schltr (TYS) is traditionally used in China to treat liver diseases like hepatitis, though its exact mechanism is not well understood.
- - This study investigates how TYS affects gut microbiota and metabolites in non-alcoholic steatohepatitis (NASH) rats, aiming to reduce NLRP3 activation, which is linked to inflammation.
- - Results indicated that TYS improved NASH symptoms by reducing body weight, lipid levels, and inflammation markers, while also enhancing gut microbiota diversity and changing its composition.
Background: Nonalcoholic steatohepatitis (NASH) is among the most common liver diseases in the world. Flavonoids from Scutellaria amoena (SAF) are used in the treatment of hepatopathy in China. However, the effect and mechanism against NASH remain unclear.
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- Yi medicine Shekaqi is recognized for its diverse pharmacological benefits and effectiveness as traditional ethnic medicine.
- Researchers isolated two new flavonoids and six known flavonoids from Shekaqi, determining their structures using spectral analysis.
- The extracted compounds demonstrated strong in vitro lipid-lowering activities, effectively reducing both total cholesterol and triglyceride levels induced by lipopolysaccharides (LPS).