The study aimed to create a method to select HLA compatible platelets for patients experiencing immune platelet transfusion failure (IPTR) by combining two techniques: mean fluorescence intensity (MFI) grading and the HLAMatchmaker program for identifying donor-patient epitope mismatches.
Researchers conducted a comprehensive analysis involving 7,807 platelet (PLT) cross-matching tests and categorized MFI results into different positivity groups, allowing for a thorough evaluation of HLA Class I antibody levels in the patients.
Results showed significant differences in the positive reactions from the cross-matching tests, suggesting that the combined approach of avoiding high MFI threshold antigens and minimizing epitope mismatches effectively improves the