Facial characteristics description and classification based on 3D images of Fragile X syndrome in a retrospective cohort of young Chinese males.

Purpose: Fragile X syndrome (FXS) is a common cause of intellectual disability and autism. FXS presents with abnormal facial features, which in pediatric patients are subtler than what is seen in adults. The three-dimensional (3D) facial images, which contain more stereoscopic and subtle information than two-dimensional (2D) photographs, are increasingly being used to classify genetic syndromes.

Early Screening of Autism in Toddlers via Express-Needs-with-Pointing Protocol.

The incidence of autism spectrum disorders (ASD), a neurodevelopmental condition associated with challenges in social communication, has witnessed a remarkable surge in recent years, with adverse effects on individuals, families, and society at large. Early screening for autism ensures timely access to interventions, yet screening lacks systematic and methodical approaches for objectively quantifying social behaviors. In response to this, we propose a protocol for early assistive screening, termed the Express-Needs-with-Pointing (ENP), which employs a multi-sensor platform to quantify the one of the social skills of toddler.

High-performance sodium-ion batteries using NaPVMoO modified reduced graphene oxide (rGO) composite materials induced by imidazole ionic liquids.

Sodium-ion batteries (SIBs) have gained increasing attention as a promising alternative to lithium-ion batteries, owing to the abundance and low cost of sodium. However, despite these advantages, the performance of SIBs is hindered by the larger ionic radius of sodium, which not only reduces ion migration rates but also significantly decreases the specific capacity. To address this challenge, the present study explores the synthesis of NaPVMoO (PVMo)-modified reduced graphene oxide (rGO) composites by employing imidazole ionic liquid (IL) as electrostatic attraction agent, this approach not only prevents the aggregation of polyoxometalates (POMs) but also increases the interlayer distance of rGO, improving the battery's specific capacity and enhancing the diffusion rate of Na ions.

Development of a Radiomic Model to Detect the Retromolar Canal on Panoramic Radiographs.

Background: The retromolar canal (RMC) is an extension of the mandibular canal located in the distal region of the mandibular third molar. Accurately detecting the RMC using conventional two-dimensional images is challenging, potentially leading to anesthetic failure and sensory disorders. This study aims to explore the clinical application of a radiomic model based on panoramic radiographs in detecting the RMC.

Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus.

Severe fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV) is an emerging tick-borne disease with a high mortality rate. Haemaphysalis longicornis is the primary reservoir and vector of SFTSV. Here, we found that targeting subolesin (SUB), an anti-tick vaccine candidate, affects the infection and transmission of SFTSV in H.

PAMAM/miR-144 nanocarrier system inhibits the migration of gastric cancer by targeting mTOR signal transduction pathway.

Exogenous microRNA-144 (miR-144) is considered as a potential biological drug for gastric cancer because of its biological activity to inhibit the epithelial-mesenchymal transition (EMT). However, the specific molecular mechanisms have not been fully revealed. In addition, their vulnerability to degradation by RNA enzymes in the blood limits their bioavailability.

The impact of halogen substitution quantities on the fluorescence intensity ratio of lanthanide Schiff base complexes.

The signal intensity ratio (SIR) is a crucial factor in advancing probe technology due to its direct impact on sensitivity and precision, particularly in applications such as medical imaging, environmental monitoring, and food safety testing. However, the development of high-SIR probes is challenged by complexities in fabrication, cost, and mechanical stability. In this study, we address these limitations by investigating the role of halogen atom substitutions in modulating the intermolecular binding energy and aggregation behavior of Ce-Salen Schiff base complexes.

Sex hormones and immune regulation in ovarian cancer.

Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing a critical role in its progression and treatment response. This review explores the interplay between sex hormones, particularly estrogen and progesterone, and immune regulation in ovarian cancer. We delve into the mechanisms by which these hormones influence immune cell function, modulate immune checkpoints, and alter the tumor microenvironment.

Corneal elevation asymmetry vector: Viable predictor of severe one-year-averaged orthokeratology lens decentration.

Background: To assess the predictive value of pretreatment corneal elevation asymmetry vector (CEAV) for severe orthokeratology (Ortho-k) lens decentration (LD) in Chinese myopic adolescents.

Methods: A retrospective analysis of 247 myopic participants over one year employed a novel MATLAB algorithm to calculate CEAV and precise LD vector. Subjects were categorized into mild (<1 mm) and severe (≥1 mm) yearly averaged LD (YALD) groups.

Unique hemispherical coordination-drivened pesticide residue probes: Enhanced stability in linear recognition for trifluralin.

Trifluralin (TRL) is an effective and persistent herbicide, but its extensive and prolonged use has increasingly posed ecological and environmental health risks, making the development of convenient and rapid TRL detection methods essential for environmental protection and food safety. In the present research, a novel fluorescent probe was designed and developed, Zn-χ-L, for the rapid and selective detection of TRL in complex environments. The sensor demonstrates excellent sensitivity and stability, while also exhibiting significant resistance to interference from other pesticides and metal ions.

Cardiomyocyte-derived exosomes promote cardiomyocyte proliferation and neonatal heart regeneration.

Heart regeneration was mainly achieved by intrinsic capacity. Exosomes are crucial in cardiovascular disease, yet their involvement in myocardial regeneration remains underexplored. To understand the role of cardiomyocyte-derived exosomes (CM-Exos) in heart regeneration.

Pump-free SERS microfluidic chip based on an identification-competition strategy for ultrasensitive and efficient simultaneous detection of liver cancer-related microRNAs.

In this study, we present a pump-free SERS microfluidic chip capable of detecting liver cancer-related miR-21 and miR-155 concurrently with ultra-sensitivity and high efficiency. We employed a FeO@cDNA-AuNPs@Raman reporter@H composite structure and a recognition competition strategy. When the target miRNAs (miR-21 and miR-155) are present in the test liquid, they specifically compete with the nucleic acid complementary strand(H) of FeO@cDNA-AuNPs@Raman reporter@H, causing AuNPs to competitively detach from the surface of FeO, resulting in a decrease in the SERS signal.

Improved exopolysaccharide production by Lactiplantibacillus plantarum Z-1 under hydrogen peroxide stress and its physicochemical properties.

In this study, a strain with good exopolysaccharide (EPS)-producing ability was isolated from the fermented Benincasa hispida and identified as Lactiplantibacillus plantarum Z-1. Its EPS production was further improved by HO stress under optimized culture conditions, increasing from 180 ± 0.45 mg/L to 409.

Generation of a human induced pluripotent stem cell line (FDIBSi001-A) from a patient with ADNP syndrome carrying ADNP mutation (c. 2059 T>C).

ADNP syndrome is a neurodevelopmental disorder characterized by autism, intellectual disability, and other physical and behavioral health manifestations. Mutations in ADNP gene is responsible for ADNP syndrome. A human iPSC line with a de novo heterozygous ADNP mutation (ADNP c.

Exploring the underlying mechanisms of Danshen-Shanzha Decoction on coronary heart disease: An integrated analysis combining pharmacoinformatics and experimental validation.

Ethnopharmacological Relevance: The Danshen-Shanzha Decoction (DSD) is a renowned herbal combination consisting of the root of Salvia miltiorrhiza Bunge (known as Danshen in Chinese) and the fruits of Crataegus pinnatifida Bunge (known as Shanzha in Chinese), which has exhibited remarkable clinical efficacy in the treatment of coronary heart disease (CHD) in traditional Chinese medicine, with its earliest recorded application dating to around 202 BCE during the Han Dynasty. Despite significant advancements in the fundamental research and clinical applications of DSD over the past few decades, the precise bioactive components as well as the underlying mechanisms responsible for its protective effect on CHD remain unelucidated.

Aim Of The Study: The present study was designed to elucidate the bioactive components and potential mechanism of DSD in the treatment of CHD using in silico technologies integrated with pharmacoinformatic methods and experimental validation.

Straw return enhances grain yield and quality of three main crops: evidence from a meta-analysis.

Straw return is regarded as a widely used field management strategy for improving soil health, but its comprehensive effect on crop grain yield and quality remains elusive. Herein, a meta-analysis containing 1822 pairs of observations from 78 studies was conducted to quantify the effect of straw return on grain yield and quality of three main crops (maize, rice, and wheat). On average, compared with no straw return, straw return significantly (< 0.

Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia.

Background: This study aimed to identify the differentially expressed proteins in the vitreous humor (VH) of eyes with and without pathologic myopia (PM), providing insights into the molecular pathogenesis.

Methods: A cross-sectional, observational study was conducted. VH samples were collected from patients undergoing vitrectomy for idiopathic epiretinal membrane (ERM), macular hole (MH), or myopic retinoschisis (MRS).

Differences in T cell-associated serum markers between ischemic cardiomyopathy and dilated cardiomyopathy.

Background: Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar clinical manifestations but differ in pathogenesis. We aimed to identify T cell-associated serum markers that can be used to distinguish between ICM and DCM.

Methods: We identified differentially expressed genes (DEGs) with transcriptome sequencing data in GSE116250, and then conducted enrichment analysis of DEGs in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases.

One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation.

The skeleton is a metabolically active organ undergoing continuous remodeling initiated by bone marrow stem cells (BMSCs). Recent research has demonstrated that BMSCs adapt the metabolic pathways to drive the osteogenic differentiation and bone formation, but the mechanism involved remains largely elusive. Here, using a comprehensive targeted metabolome and transcriptome profiling, we revealed that one-carbon metabolism was promoted following osteogenic induction of BMSCs.

Potential mechanisms implied in tick infection by arboviruses and their transmission to vertebrate hosts.

Ticks can transmit many pathogens, including arboviruses, to their vertebrate hosts. Arboviruses must overcome or evade defense mechanisms during their passage from the tick gut to the hemolymph, salivary glands, and the feeding site in the host skin. This review summarizes current knowledge of defense mechanisms in specific tick tissues and at the feeding site in the host skin.

The mA eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation.

Acute lung injury (ALI) is a serious disorder characterized by the release of pro-inflammatory cytokines and cascade activation of macrophages. Ferroptosis, a form of iron-dependent cell death triggered by intracellular phospholipid peroxidation, has been implicated as an internal mechanism underlying ALI. In this study, we investigated the effects of mA demethylase fat mass and obesity-associated protein (FTO) on the inhibition of macrophage ferroptosis in ALI.

Reference-free calibration method for asynchronous rotation in robotic CT.

Background: Geometry calibration for robotic CT system is necessary for obtaining acceptable images under the asynchrony of two manipulators.

Objective: We aim to evaluate the impact of different types of asynchrony on images and propose a reference-free calibration method based on a simplified geometry model.

Methods: We evaluate the impact of different types of asynchrony on images and propose a novel calibration method focused on asynchronous rotation of robotic CT.

Oxygen Vacancies Enrichment in Citric Acid-Assisted Synthesis of Zirconia Supported Ni Catalyst for Highly Selective Hydrogenolysis of 5-Hydroxymethylfurfural.

2, 5-Dimethylfuran (DMF), which is a promising new-generation liquid biofuel, has attracted widespread attention owing to the sustainability of biomass-derived energy sources. In this study, a highly dispersed zirconia-supported nickel catalyst (CA-Ni/ZrO) was prepared via citric acid-assisted wetness impregnation for the selective hydrogenolysis of 5-hydroxymethylfurfural (HMF) to produce DMF. The characterization results confirmed the presence of Zr species in the mesoporous CA-Ni/ZrO catalyst and the formation of oxygen vacancies during its preparation, which led to the formation of a large number of catalytically active sites for the adsorption and activation of the C=O/C-O groups.