Publications by authors named "Qiong Wang"

Background: Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the pathogenesis of Alzheimer's disease (AD). However, the precise types of interferons and related cytokines, both from the brain and periphery, responsible for cognitive impairment in patients with AD remain unclear.

Methods: A total of 131 participants (78 [59.

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Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer, yet early, precise, and noninvasive detection continues to pose a considerable clinical challenge. Glypican-3 (GPC3), a membrane-bound proteoglycan, is markedly overexpressed in most HCC cases, while exhibiting low expression in normal and hepatitis-affected liver tissues. Given its crucial role in malignant transformation and tumor progression, GPC3 emerges as a compelling target for imaging.

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Background: Post-COVID-19 pulmonary fibrosis is a significant long-term respiratory morbidity affecting patients' respiratory health. This exploratory study aims to investigate the incidence, clinical characteristics, and acute-phase risk factors for pulmonary fibrosis in COVID-19 patients. Additionally, it evaluates pulmonary function and chest CT outcomes to provide clinical evidence for the early identification of high-risk patients and the prevention of post-COVID-19 pulmonary fibrosis.

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As an "upstream" process in biorefinery, biomass dismantling can dismantle the natural stable structure of lignocellulosic biomass and separate its three major components. To increase the value of the entire biomass by fully utilizing the three main components (cellulose, lignin, and hemicellulose), this study proposes a two-step decomposition system combining formic acid (FA) pretreatment and ethylene glycol-NaOH (EGA) dismantling, aiming to effectively convert sugarcane bagasse into xylose, fermentable glucose, and high-value lignin. In the first step, FA pretreatment removed 79.

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Patients with hematologic malignancies (HM) are highly susceptible to bloodstream infection (BSI), particularly those undergoing treatments such as chemotherapy. A common and debilitating side effect of chemotherapy is oral and intestinal mucositis. These Patients are also at high risk of developing sepsis, which can arise from mucosal barrier injuries and significantly increases mortality in these patients.

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Ischemia-reperfusion injury (IRI) is a common and clinically significant form of tissue damage encountered in medical practice. This pathological process has been thoroughly investigated across a variety of clinical settings, including, but not limited to, sepsis, organ transplantation, shock, myocardial infarction, cerebral ischemia, and stroke. Intestinal IRI, in particular, is increasingly recognized as a significant clinical entity due to marked changes in the gut microbiota and their metabolic products, often described as the body's "second genome.

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Background: Pregnant individuals are particularly susceptible to non-optimal temperatures due to their physiological status. Moreover, pregnancy is a crucial period for programming fetal health. Quantifying the impact of non-optimal temperature exposure and the contribution of anthropogenic climate change is crucial for mitigating and adapting to climate-related health risks.

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Background: -secretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD). We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.

Methods And Results: We enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer's disease as controls.

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Purpose: Emotion dysregulation in young adults has become an important issue in the literature. By building a moderated mediating model, this study tested the underlying mechanism of young adults' emotion dysregulation by examining the indirect effect of parental self-efficacy (PSE) on family cohesion and the moderating effect of parents' affective involvement.

Methods: Two complementary approaches were adopted to validate our hypotheses using three-stage longitudinal data from 537 Chinese families.

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Currently available animal models for calcium oxalate kidney stones are limited in their translational potential. Particularly with increasing interest in gut microbiota involvement in kidney stone disease, there are limited animal models which can be used. As such, we have developed a novel diet-induced hyperoxaluria murine model which addresses some of the shortcomings of other currently available models.

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Rationale: Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease typically coexisting with intestinal microbiota dysbiosis, oxidative stress, and an inflammatory response. Although its underlying mechanism of action is unclear, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have demonstrated significant therapeutic efficacy for UC.

Methods: The mechanism of action of MMRAC in the treatment of UC model was investigated by combining metabolomics, transcriptomics, and intestinal microbiota detection techniques.

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Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.

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Article Synopsis
  • The study explores the potential of using bacterial cellulose as a carrier for glycyrrhetinic acid, a compound known for its anti-inflammatory properties useful in treating eczema.
  • This research focuses on creating and evaluating glycyrrhizic acid hydrogels utilizing unmodified bacterial cellulose, employing methods like physical crosslinking and optimization techniques.
  • Findings indicate that the glycyrrhizic acid-bacterial cellulose hydrogel shows good skin permeability, minimal irritation, and effectively supports skin recovery from induced eczema, outperforming conventional hydrogels.
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Leucine dehydrogenase (LeuDH) is a promising enzyme for the industrial production of L-tert-leucine (L-Tle), but its catalytic activity toward trimethylpyruvate (TMP) requires enhancement. In this study, we employed a semi-rational design approach involving homology modeling of LeuDH from Exiguobacterium sibiricum (EsiLeuDH) and molecular docking with TMP to predict potential mutation sites. These sites were tested using an alanine scanning strategy to assess their impact on enzymatic activity, followed by site-saturation mutagenesis and iterative saturation mutagenesis.

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Ethnopharmacological Relevance: Huangkui Capsule (HKC) is a traditional Chinese medicinal preparation. Numerous clinical studies have reported that HKC has a good nephroprotection effect. The clinical application of cisplatin is greatly limited by its nephrotoxicity, and HKC shows promise in preventing cisplatin-induced nephrotoxicity (CIN).

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Exploring the mechanisms of the impacts of urbanization on soil aggregate stability and soil organic carbon (SOC) content will contribute to improving soil quality in urban greenspaces. Using the built-up area of Nanchang City, Jiangxi Province as a case study, the urbanization intensity was differentiated by impervious rate, and the vegetation characteristics and soil properties of 184 greenspace plots were investigated and determined. Variations in the stability parameters (geometric mean diameter, mean weight diameter, fractal dimension, and unstable aggregate index) and SOC contents across soil aggregate-size fractions (>2, 1-2, 0.

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Sepsis is a severe, potentially fatal condition defined by organ dysfunction due to excessive inflammation. Its complex pathogenesis and poor therapeutic outcomes pose significant challenges in treatment. Macrophages, with their high heterogeneity and plasticity, play crucial roles in both the innate and adaptive immune systems.

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Article Synopsis
  • Conventional white light imaging (WLI) often misses early gastric cancer (EGC) cases, prompting a study to compare its effectiveness against linked color imaging (LCI) to improve diagnostic practices.
  • The study evaluated 11 research articles, analyzing the diagnostic performance using methods like the QUADAS-2 tool and Split Component Synthesis (SCS).
  • Results showed LCI significantly outperformed WLI in detecting EGC and gastrointestinal metaplasia (GIM), with higher sensitivity and specificity, establishing LCI as the preferred screening method for both conditions.
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The formation of transcription regulatory complexes by the association of Smad4 with Smad2 and Smad3 (Smad2/3) is crucial in the canonical TGFβ pathway. Although the central requirement of Smad4 as a common mediator is emphasized in regulating TGFβ signaling, it is not obligatory for all responses. The role of Smad2/3 independently of Smad4 remains understudied.

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Voltage-gated potassium channel subfamily q member 4 (Kcnq4) is predominantly expressed by hair cells and auditory neurons and regulates the neuronal excitability in the auditory pathway. Although it is further detected in myelinated large-diameter dorsal root ganglia (DRG) neurons in the periphery, the expression and function of Kcnq4 channel in nociceptors remains unknown. Here we showed that Kcnq4 is substantially expressed by unmyelinated small-diameter DRG neurons in both human and mouse.

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Background: Thyroid hormone resistance syndrome (RTH) is a rare hereditary endocrine disease that can manifest as hyperthyroidism, hypothyroidism, or remain asymptomatic. It can easily be confused with other types of thyroid diseases. The diagnosis of the disease depends on genetic testing.

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Synopsis of recent research by authors named "Qiong Wang"

  • - Qiong Wang's recent research highlights the protective effects of Asiaticoside against diabetic nephropathy, emphasizing its anti-inflammatory, antioxidant, and anti-fibrotic properties through the NRF2/HO-1 pathway, showcasing potential therapeutic applications in diabetes-related complications
  • - Another significant study explores the role of ARID1A and GATA2 in regulating trophoblast cell senescence under hyperglycemic conditions, shedding light on the mechanisms potentially contributing to gestational diabetes mellitus and its impact on placental function
  • - Wang also conducts research on the microbial diversity in urban ancient tree rhizospheres, revealing insights into the effects of urbanization on these ecosystems and promoting strategies for the rejuvenation of ancient trees through the understanding of their microbial communities