Publications by authors named "Qiong Mei"

Intrahepatic cholangiocarcinoma (ICC) is characterized by poor prognosis and limited treatment. Hepatocytes have been considered as one of the origins of ICC, however, the underlying mechanisms remain unclear. Here, we found mesencephalic astrocyte-derived neurotrophic factor (MANF), a hepatoprotective factor, was exceptionally upregulated in human ICC tissues and experimental mouse ICC models induced by sleeping beauty transposon (SBT) or thioacetamide (TAA) challenge.

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Liver regeneration is an intricate pathophysiological process that has been a subject of great interest to the scientific community for many years. The capacity of liver regeneration is very critical for patients with liver diseases. Therefore, exploring the mechanisms of liver regeneration and finding good ways to improve it are very meaningful.

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The growing utilization of Traditional Chinese Medicine (TCM) has resulted in an increase in wastewater. Herein, a new kind of organic-inorganic redox mediator membrane by immobilizing γ-FeO(OH) and aloe-emodin(AE) with the characteristic large π-conjugation anthraquinone structure on PVDF membrane was innovatively achieved. AE exhibiting both electron deficiency and redox activity possesses a co-catalyst role in degradation of tannic acid (TA), aiding in the separation of charge carriers through the sequential hydrogenation and dehydrogenation of AE.

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Article Synopsis
  • Ketoprofen (KET) is a non-steroidal anti-inflammatory drug that poses health risks due to its accumulation in water and low biodegradability, necessitating its breakdown in aqueous environments.
  • The study investigates the degradation of KET using ozone and hydroxyl radicals (HO) through density functional theory (DFT), highlighting that while ozonation is slow, HO reactions significantly enhance degradation efficiency.
  • The research also examines factors affecting degradation efficiency, concluding that most degradation products are non-toxic, though some, particularly those with benzene rings, remain hazardous.
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Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but its health risks to different organisms are poorly understood. This study investigated the neurotoxic responses of honeybee/cotton aphid nicotinic acetylcholine receptors (nAChRs) to chiral dinotefuran at the enantiomeric scale and demonstrated the microscopic mechanism of species selectivity in nAChR-mediated enantioselective neurotoxicity. The findings indicated that (S)-dinotefuran had a higher affinity for honeybee nAChR than (R)-dinotefuran whereas both enantiomers exhibited similar bioactivity toward cotton aphid nAChR.

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Dysplasia and invasive defects in early trophoblasts contribute to unexplained recurrent miscarriages (URMs). Mesencephalic astrocyte-derived neurotrophic factor (MANF) inhibits migration and invasion in some cancer cells, but its role in pregnancy-related diseases remains unresolved. Here, we found that MANF levels in the peripheral blood and aborted tissue of URM women were higher than in normal controls, irrespective of pregnancy or miscarriage.

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Nitrogen fertilization can promote rice yield but decrease resistance to sheath blight (ShB). In this study, the () mutant that exhibited less susceptibility to ShB but without compromising yield under NH fertilization was screened. NRT1.

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The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been recently identified as a neurotrophic factor, but its role in hepatic fibrosis is unknown. Here, we found that MANF was upregulated in the fibrotic liver tissues of the patients with chronic liver diseases and of mice treated with CCl. MANF deficiency in either hepatocytes or hepatic mono-macrophages, particularly in hepatic mono-macrophages, clearly exacerbated hepatic fibrosis.

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Article Synopsis
  • Chiral organophosphorus pollutants, specifically isocarbophos, pose neurotoxic risks that haven't been fully evaluated, prompting research into their effects on nerve cells (SH-SY5Y) and the role of acetylcholinesterase (AChE).
  • Cell assays reveal that one enantiomer of isocarbophos is significantly more toxic than the other, with distinct inhibitory effects on cell survival and AChE activity, showing a clear dependence on dosage.
  • Molecular experiments highlight that the differing toxic actions are due to variations in how the two enantiomers interact with AChE, particularly through noncovalent interactions influenced by the structural characteristics of isocarboph
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Article Synopsis
  • Mesencephalic astrocyte-derived neurotrophic factor (MANF) plays a key role in reducing inflammation in macrophages and is linked to immune regulation, making it a candidate for therapeutic use in inflammatory bowel disease (IBD).
  • In studies involving both human IBD patients and mice with induced colitis, it was found that MANF levels were significantly higher in macrophages, and a deficiency in MANF led to worse colitis symptoms.
  • Treatment with recombinant human MANF improved colitis symptoms in mice and indicated that MANF helps control inflammation by modulating immune responses and preventing the transformation of macrophages into a more inflammatory state.
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Sheath blight (ShB) severely threatens rice cultivation and production; however, the molecular mechanism of rice defence against ShB remains unclear. Screening of transposon Ds insertion mutants identified that Calcineurin B-like protein-interacting protein kinase 31 (CIPK31) mutants were more susceptible to ShB, while CIPK31 overexpressors (OX) were less susceptible. Sequence analysis indicated two haplotypes of CIPK31: Hap_1, with significantly higher CIPK31 expression, was less sensitive to ShB than the Hap_2 lines.

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Recent research revealed inhibition or enhancement of dissolved organic matter (DOM) to the degradation of trace organic contaminants (TrOC) in natural and engineered water systems. Phenols containing acetyl, carboxyl, formyl, hydroxy, and methoxy groups were selected as the model DOM to quantitatively study their roles in the degradation of simple anilines, sulfonamide antibiotics, phenylurea pesticides by sulfate radicals (SO). Experimental results found that p-methoxyphenol inhibited aniline and sulfamethoxazole degradation by thermally activated peroxydisulfate (TAP), while p-acetylphenol slightly promoted aniline degradation.

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Introduction: Rhizoctonia solani, the causative agent of the sheath blight disease (ShB), invades rice to obtain nutrients, especially sugars; however, the molecular mechanism via which R. solani hijacks sugars from rice remains unclear.

Objectives: In this study, rice-R.

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Sheath blight (ShB) caused by is a major disease of rice, seriously affecting yield; however, the molecular defense mechanism against ShB remains unclear. A previous transcriptome analysis of rice identified that inoculation significantly induced . Genetic studies using and overexpressing plants identified that positively regulates ShB resistance.

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Background: Hypokalemia is a frequent electrolyte imbalance in patients with COVID-19. The aim of this study was to estimate the association between hypokalemia and clinical prognosis in patients with moderate COVID-19.

Methods: A single-center, retrospective, observational study was conducted on 81 non-ICU admitted patients with moderate COVID-19 according to the criteria issued by the Chinese Health Bureau in the Third People's Hospital of Yangzhou (Northern Jiangsu People's Hospital New District Branch) from 4th to 25th August 2021.

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Rice bacterial blight caused by pv. () seriously affects rice yield production. The discovery and application of broad-spectrum resistance genes are of great advance for disease resistance breeding.

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Metal-free photocatalysts for high efficient photocatalytic degradation of pollutants have attracted growing concern in recent years. Herein, relying on density functional theory (DFT) calculations, boron and phosphorus doped CN layers were explored for the potential of utilization as photocatalysts for 4, 5-dichloroguaiacol (4, 5-DCG) removal. Our computations revealed that the adsorption energy of 4, 5-DCG on B@N-doped CN layers were 26.

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Catechol pollutants (CATPs) serving as chelating agents could coordinate with many metal ions to form various CATPs-metal complexes. Little information is available on the effects of complexation of metal ions on CATPs degradation. This work presents a systematical study of •OH-mediated degradation of catechol and catechol-metal complexes over the whole pH range in advanced oxidation processes (AOPs).

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Sheath blight (ShB) is one of the most common diseases in rice that significantly affects yield production. However, the underlying mechanisms of rice defense remain largely unknown. Our previous transcriptome analysis identified that infection with Rhizoctonia solani significantly induced the expression level of SWEET2a, a member of the SWEET sugar transporter.

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As an excellent conductive herbicide, swep is widely used in weed removal. Its remaining in atmosphere and water can not only contaminate the environment but also pose a threat to human health. This work presented a systematic theoretical study of HO-mediated degradation mechanisms and kinetics of swep in atmosphere and water environment.

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Rice () production is damaged to a great extent by sheath blight disease (ShB). However, the defense mechanism in rice against this disease is largely unknown. Previous transcriptome analysis identified a significantly induced eukaryotic () after the inoculation of .

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Atmospheric pressure cold plasma has shown multiple biological effects of anti-bacteria and anti-cancer. In this study, the effect of atmospheric pressure cold plasma on respiratory inflammation and oxidant stress is explored. Tunicamycin was used to stimulate human bronchial epithelial cells (HBECs) and A549 cells for inflammatory response and oxidative stress, followed by atmospheric pressure cold plasma treatment.

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Article Synopsis
  • Research on radical oxidation processes using peracetic acid is limited, focusing on the reactions of acetaminophen (ACT) with hydroxyl and organic radicals.
  • The study calculated the reactivities of key organic radicals and found that CHCOO and HO are the most effective in degrading ACT, with CHCOO also playing a significant role in hydroxylating aromatic compounds.
  • CHCOOO demonstrated high reactivity, particularly with phenolate and aniline, and the hydroxylation by CHCOO may produce more toxic hydroxylated products.
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Pyrethroid, a pesticide widely used worldwide, could mimic, block, or synergize the effects of endogenous hormones in humans or mammals after entering into the atmosphere and after being sprayed and applied in large quantities. This research aims to study the mechanism, kinetics, and eco-toxicity evaluation of the ozonolysis of permethrin (PER)-one of the typical pyrethroid (type I) pesticides. Existing experimental studies only predicted that ozonolysis of PER could generate a cycloperoxy analogue of PER (IM13-1-11), and the reaction mechanism has not yet been completed.

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