Publications by authors named "Qiong Ding"

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation.

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Adaptive behavior requires the ability to shift responding within (intra-dimensional) or between (extra-dimensional) stimulus dimensions when reward contingencies change. Studies of shifting in humans have focused mainly on the prefrontal cortex and/ or have been restricted to indirect measures of neural activity such as fMRI and lesions. Here, we demonstrate the importance of the amygdala and hippocampus by recording local field potentials directly from these regions intracranially in human epilepsy patients.

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The voluntary nature of decision-making is fundamental to human behavior. The subthalamic nucleus is important in reactive decision-making, but its role in voluntary decision-making remains unclear. We recorded from deep brain stimulation subthalamic electrodes time-locked with acute stimulation using a Go/Nogo task to assess voluntary action and inaction.

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  • Resistance to sorafenib treatment for advanced hepatocellular carcinoma (HCC) negatively impacts patient outcomes, and the role of the extracellular matrix in this resistance is not well understood.
  • Research identified FN-EDA from cancer-associated fibroblasts as a key factor in this resistance, as it enhances SHMT1 enzyme levels in HCC cells through the TLR4/NF-κB signaling pathway, helping cells cope with the oxidative stress from sorafenib.
  • Clinical validation showed that targeting the FN-EDA/SHMT1 pathway could potentially improve how well patients respond to sorafenib, indicating a new therapeutic strategy for HCC.
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  • Deep brain stimulation of the subthalamic nucleus can effectively treat conditions like Parkinson's disease and OCD, but it also has mixed effects on impulsivity, enhancing some types while reducing risk-taking behavior.
  • In a study using a card gambling task and brain recordings, acute stimulation was found to decrease risk-taking and increase certain brain activity related to decision-making processes.
  • These results suggest a complex relationship between stimulation effects, impulsivity types, and brain connectivity, which could inform better treatments for neuropsychiatric disorders.
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Molecularly imprinted polymers (MIPs) have been widely used as artificial recognition elements in sensing applications. However, their electrochemical sensing performance is generally hampered by limited affinity and uncontrolled condition change. In this work, a novel MIP electrochemical sensor based on metal coordination interaction was prepared and used for the recognition and ratiometric detection of lidocaine (LC).

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The fabrication of clinically relevant synthetic bone grafts relies on combining multiple biodegradable biomaterials to create a structure that supports the regeneration of defects while delivering osteogenic biomolecules that enhance regeneration. MicroRNA-200c () functions as a potent osteoinductive biomolecule to enhance osteogenic differentiation and bone formation; however, synthetic tissue-engineered bone grafts that sustain the delivery of for bone regeneration have not yet been evaluated. In this study, we created novel, multimaterial, synthetic bone grafts from gelatin-coated 3D-printed polycaprolactone (PCL) scaffolds.

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Objective: To investigate the relationship between FKBP prolyl isomerase 5 () gene expression and CD8 T cells in tumour progression and immunology of the luminal B subtype of breast cancer (LBBC) using bioinformatics analyses.

Methods: The Gene Expression Profiling Interactive Analysis 2, Human Protein Atlas and breast cancer gene-expression miner v4.5 databases were used for data mining and analysing , its co-expressed genes and CD8 T cell-related markers.

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MicroRNA (miR)-200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), the most prevalent head and neck cancer with high recurrence, metastasis, and mortality rates. However, -based gene therapy to inhibit OSCC growth and metastasis has yet to be reported. To develop an miR-based gene therapy to improve the outcomes of OSCC treatment, this study investigates the feasibility of plasmid DNA encoding delivered via non-viral CaCO -based nanoparticles to inhibit OSCC tumor growth.

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Introduction: Deep brain stimulation (DBS) studies in Parkinson's Disease (PD) targeting the subthalamic nucleus (STN) have characterized its spectral properties across cognitive processes. In emotional evaluation tasks, specific alpha frequency (8-12 Hz) event-related de-synchronization (ERD) (reduced power) has been demonstrated. The time-locked stimulation of STN relative to stimuli onset has shown subjective positive valence shifts with 10 Hz but not with 130 Hz.

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Unlabelled: Obesity, a worldwide health problem, increases the risk for developing metabolic diseases such as insulin resistance and diabetes. It is well recognized that obesity-associated chronic inflammation plays a key role in the pathogenesis of systemic metabolic dysfunction. Previously, we revealed an anti-inflammatory role for spent culture supernatants isolated from the oral commensal bacterial species Here, we identified that 6-hydroxyhexanoic acid (6-HHA), a medium chain fatty acid (MCFA), is the one of the key components of .

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As an important forage crop worldwide, the growth and productivity of orchardgrass are greatly impacted by high temperatures. However, little information is known about how orchardgrass proteomic changes under heat conditions. Therefore, the present study investigated the proteomics and physiological changes in 667 [AKZ-NRGR667 (heat-tolerant)] and 7602 [PI237602 (heat-sensitive)] under heat stress (40/35 °C).

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  • Elevated intolerance of uncertainty is a key feature of obsessive-compulsive disorder (OCD), impacting decision-making under risk.
  • A study involving 83 participants used MRI during a card gambling task to explore how OCD affects uncertainty processing and decision-making speed and accuracy.
  • Results showed that OCD patients were more cautious, accumulated evidence more slowly, and displayed impaired neural responses to uncertainty, suggesting these cognitive traits are consistent in OCD rather than changing with symptoms.
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This study evaluates the phenolic profile as well as the antioxidant properties of Shennongjia honey through a comparison with honey in China. The total phenolic content (TPC) ranges from 263 ± 2 to 681 ± 36 mg gallic acid/kg. The total flavonoids content (TFC) ranges from 35.

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  • Ablative procedures like anterior capsulotomy can be effective for treating stubborn obsessive-compulsive disorder (OCD), particularly by targeting specific brain pathways involved in emotional regulation.
  • A study involving OCD patients post-capsulotomy showed significant improvements in symptoms and quality of life without affecting mood or cognitive performance on various tasks.
  • Functional MRI results indicated changes in brain activity and connectivity associated with negative emotional responses, suggesting potential pathways for enhancing future OCD treatments using neuromodulation techniques.
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Introduction: This study aimed to explore the association of serum lactate with clinical outcomes in elderly patients with sepsis based on data from the MIMIC-IV database.

Methods: All elderly patients with sepsis (age ≥ 65 years) were included. Different models were constructed for exploring the relationships between lactate and 28-day mortality.

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  • The study investigates the interactions and emotional responses of the amygdala, orbitofrontal cortex (OFC), and medial prefrontal cortex (mPFC) using high-fidelity intracranial electroencephalography (iEEG) in 35 epilepsy patients, focusing on their activity during emotional picture viewing.
  • Findings reveal that negative emotional conditions trigger increased broadband gamma and beta activity in the amygdala and OFC, with specific changes in the mPFC, highlighting a complex relationship between these brain regions and emotional valence.
  • The results confirm a one-way influence of the mPFC over the amygdala and a two-way exchange between the OFC and both the amygdala and mP
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  • Neurons in the primate lateral habenula respond to punishments and are suppressed by rewards, influencing behavior and linked to depressive symptoms, particularly with ketamine treatment.
  • Researchers recorded local field potentials from the habenula in 12 humans undergoing deep brain stimulation, overcoming past imaging limitations, which allowed them to observe neural activity during tasks involving monetary gains and losses.
  • The study found that high-frequency gamma activity increased with losses and decreased with rewards, reflecting cognitive processes in decision-making, and suggests that understanding these dynamics could enhance deep brain stimulation therapies for mood disorders.
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Background: The oral commensal bacterial species Streptococcus gordonii has been reported to regulate the inflammation of oral epithelial cells stimulated by the periodontal pathogen Porphyromonas gingivalis. This study investigated the activities of S. gordonii metabolites in S.

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Purpose: To investigate the association of body mass index (BMI) and waist-to-hip ratio (WHR) with macular vessel density (VD) and foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), in healthy Chinese adults.

Design: Cross-sectional study.

Methods: A total of 1555 Chinese adults aged ≥ 50 years with no history of ocular disease were recruited from communities in Guangzhou, China.

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miRNAs have been shown to improve the restoration of craniofacial bone defects. This work aimed to enhance transfection efficiency and -induced bone formation in alveolar bone defects via plasmid DNA encoding delivery from CaCO nanoparticles. The CaCO/ delivery system was evaluated (microscopy, transfection efficiency, biocompatibility) and -induced alveolar bone formation was assessed via micro-computed tomography and histology.

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There is currently insufficient evidence of correlation between on-admission serum uric acid and in-hospital mortality of patients with acute type A aortic dissection. Thus, this study analysed the relation between serum uric acid and in-hospital deaths in patients with acute type A aortic dissection. A total of 1048 patients with acute type A aortic dissection participated in this study between January 2010 and December 2018.

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Objective: This study aimed to explore the relationship between red cell distribution width (RDW) and in-hospital mortality in septic shock based on a large-scale public database.

Methods: All patients with septic shock in MIMIC-IV were enrolled. Based on RDW values, the general characteristics of different groups were compared.

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Background: The subthalamic nucleus (STN) is an effective deep brain stimulation target for Parkinson disease (PD) and obsessive-compulsive disorder and has been implicated in reward and motivational processing. In this study, we assessed the STN and prefrontal oscillatory dynamics in the anticipation and receipt of reward and loss using a task commonly used in imaging.

Materials And Methods: We recorded intracranial left subthalamic local field potentials from deep brain stimulation electrodes and prefrontal scalp electroencephalography in 17 patients with PD while they performed a monetary incentive delay task.

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