YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling.

The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon cancer. Our previous studies highlighted the potent anti-cancer properties of the principal compounds found in (YTE-17), attributing these effects to the regulation of multiple signaling pathways. However, knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is limited.

Serum miR-485-5p expression and clinical significance in epilepsy secondary to cerebral infarction.

Introduction: MicroRNA (miR)-485-5p has been linked to regulation of neurological disorders. The current study examined miR-485-5p levels in patients with epilepsy secondary to cerebral infarction and investigated its predictive significance.

Material And Methods: The Gene Expression Omnibus (GEO) database was employed to screen differentially expressed miRNAs in cerebral infarction and epilepsy.

Dysregulation of Serum UCA1 and Its Clinical Significance in Patients with Acute Cerebral Infarction.

Objective: To investigate the expression of lncRNA UCA1 in serum of patients with acute cerebral infarction (ACI) and its relationship with prognosis.

Methods: The serum lncRNA UCA1 level in participants was detected, and the correlation between the neurological function score (NIHSS score) of ACI patients and lncRNA UCA1 expression was analyzed. Patients were followed up at 3 months after discharge and were divided into favorable and unfavorable prognostic groups according to the modified Rankin scale (mRs).

Pulsatilla Decoction and its bioactive component β-peltatin induce G2/M cell cycle arrest and apoptosis in pancreatic cancer.

Background: Pancreatic cancer (PAC), a malignancy that is fatal and commonly diagnosed at a late stage. Despite considerable advancements in cancer treatment, the survival rate of PAC remains largely consistent for the past 60 years. The traditional Chinese medicine formula Pulsatilla Decoction (PD) has been clinically used to treat inflammatory diseases for millennia and recently as a supplementary anti-cancer treatment in China.

Exosomes derived from MDR cells induce cetuximab resistance in CRC via PI3K/AKT signaling‑mediated Sox2 and PD‑L1 expression.

The anti-EGFR antibody cetuximab is used as a first-line targeted therapeutic drug in colorectal cancer. It has previously been reported that the efficacy of the EGFR antibody cetuximab is limited by the emergence of acquired drug resistance. In our previous study the transmissibility effect of exosomes from drug resistant tumor cells to sensitive tumor cells was identified.

A novel dithiourea-appended naphthalimide "on-off" fluorescent probe for detecting Hg and Ag and its application in cell imaging.

An effective dithiourea-appended 1,8-naphthalimide fluorescent probe was designed and synthesized. This probe could recognize Hg and Ag sensitively and selectively in neutral and alkaline conditions. Moreover, the probe detected Hg alone at pH between 2 and 6.

A new perylene-based fluorescent pH chemosensor for strongly acidic condition.

A highly selective and sensitive pH chemosensor N,N-bis[(2-thiophene)-ethyl]-3,4,9,10-perylene tetracarboxylic diimide (TEPTD) was designed and synthesized through Schiff-base condensation reaction. It exhibited large Stokes shifts, good water solubility, excellent selectivity and outstanding photo-stability. The pK of the probe was 3.

A highly sensitive and selective fluorescent probe for determination of Cu (II) and application in live cell imaging.

A highly sensitive fluorescent probe, 2‑butyl‑6‑(2‑ethylidenehydrazinyl)‑1H‑benzo[de]isoquinoline‑1,3(2H)‑dione (P) has been designed and synthesized to detect Cu in CHCN-HEPES (4:1, v/v, pH = 7.4) solution. This probe functions via a distinctive hydrolysis mechanism through Cu-promoted accompany by extinction of the fluorescent and other competing metal ions did not showed any interference.

A Highly Selective and Sensitive Fluorescent Turn-Off Probe for Cu Based on a Guanidine Derivative.

A new highly selective and sensitive fluorescent probe for Cu, --butyl-4-(1'-cyclooctene-1',3',6'-triazole)-1,8-naphthalimide (), was synthesized and evaluated. The structure of compound was characterized via IR, ¹H-NMR, C-NMR and HRMS. The fluorescent probe was quenched by Cu with a 1:1 binding ratio and behaved as a "turn-off" sensor.