- The study investigates the effectiveness of combining immune checkpoint inhibitors (ICIs) like toripalimab and pembrolizumab with the anti-angiogenic drug sunitinib in treating cancer of unknown primary (CUP), aiming to improve survival rates.
- Researchers compared the effects of the combined treatment against separate treatments and matched control groups, utilizing structural equation modeling to analyze potential survival markers.
- Results showed that patients receiving the combined treatment had significantly better survival outcomes than those on separate treatments, with specific angiogenic markers influencing the efficacy of the PD-1 blockade.