Publications by authors named "Qinzheng Chang"
Ethnopharmacological Relevance: Liver fibrosis is a critical pathological process in the progression of chronic liver injury, ultimately resulting in cirrhosis, for which currently available therapeutic interventions remain inadequate. Among these, the Qianggan Ruanjian Pill (QGRJP) has emerged as a clinically experienced formula with notable therapeutic efficacy against liver fibrosis. However, the precise underlying mechanisms require further investigation.
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- Clear cell renal cell carcinoma (ccRCC) shows altered metabolism, with FUCA1 expression downregulated, correlating with poorer patient outcomes.
- Enhancing FUCA1 levels reduces ccRCC cell invasion and migration, indicating its potential protective role, influenced by the transcription factor CTCF.
- FUCA1 impacts the autophagy process in ccRCC by affecting autophagosome-lysosome fusion, while FUCA2 is closely related and serves as a prognostic marker.
Article Synopsis
- This study investigates how absolute neutrophil count (ANC) and absolute monocyte count (AMC) can help distinguish between renal cell carcinoma (RCC) and renal angiomyolipoma (RAML) and their implications on RCC patient prognosis.
- The research analyzed data from 1120 patients, finding significantly higher ANC and AMC levels in RCC patients compared to those with RAML, and noted associations with factors like smoking history and tumor characteristics.
- Additionally, high ANC and AMC levels were linked to poorer overall survival (OS) and progression-free survival (PFS) in RCC patients, with ANC being identified as a potential independent prognostic factor.
Background: Powdery mildew, caused by Eeysiphe heraclei, seriously threatens Heracleum moellendorffii Hance. Plant secondary metabolites are essential to many activities and are necessary for defense against biotic stress. In order to clarify the functions of these metabolites in response to the pathogen, our work concentrated on the variations in the accumulation of secondary metabolites in H.
View Article and Find Full Text PDFPurpose: Immune checkpoint therapy (ICT) provides a new idea for the treatment of advanced clear cell renal cell carcinoma (ccRCC), which can bring significant benefits to patients. However, the clinical application of ICT is limited because of the lack of predictive biomarkers to select potential responders. This study aims to propose a new biomarker to predict the response to Nivolumab in patients with ccRCC.
View Article and Find Full Text PDFClinically, for testicular tumor patients with negative tumor markers, how to distinguish the malignant from the benign is a difficult problem. This study aimed to assess the clinical significance of the absolute monocyte count (AMC) in differential diagnosis of testicular germ cell tumor with stage S0 (TGCTS0) and benign testicular tumor. In this retrospective single-center study, a total of 90 patients newly diagnosed with benign testicular tumor or TGCTS0 were reviewed.
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