Publications by authors named "Qinyu Tang"
Discovering KYNU as a feature gene in hidradenitis suppurativa.
Int J Immunopathol Pharmacol
November 2023
Background: Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin condition characterized by nodules, abscesses, and fistulae in skin folds. The underlying pathogenesis of HS remains unclear, and effective therapeutic drugs are limited.
Methods: We acquired mRNA expression profiles from the Gene Expression Omnibus (GEO) database and conducted differential expression analysis between control and HS samples using R software.
Background: m6A regulators have important roles in a variety of autoimmune diseases, but their potential function in scleroderma, a refractory connective tissue disease, remains unclear. Tenascin C (TNC) is known to be a factor promoting collagen deposition in the development of scleroderma, but the regulatory relationship between TNC and m6A regulators is unknown.
Methods: We extracted GSE33463 data consisting of forty-one healthy controls and sixty-one patients with scleroderma, and we analyzed the expression levels of twenty-one m6A regulators as well as the associations between them.
Article Synopsis
- Systemic sclerosis (SSc) is a rare autoimmune disease causing severe skin fibrosis, and this study aimed to uncover specific genes and potential treatments using advanced bioinformatics techniques.
- Researchers analyzed four datasets to identify 254 differentially expressed genes (DEGs) with a focus on tissues related to the immune and musculoskeletal systems, leading to the identification of significant hub genes like Serpine1, CCL2, IL6, and ISG15.
- The study constructed a competing endogenous RNA (ceRNA) network and used ROC curve analysis to evaluate biomarker effectiveness, ultimately linking several drugs to the identified hub genes for future treatment possibilities.
Article Synopsis
- - The study aimed to evaluate the effectiveness of combining EGFR-TKIs with antiangiogenic agents in treating non-small cell lung cancer patients with two specific genetic mutations: exon 19 deletion and exon 21 Leu858 Arg.
- - Researchers conducted a systematic review of five high-quality randomized control trials involving 1533 patients, analyzing their progression-free survival (PFS) with the combination treatment versus EGFR-TKI alone.
- - Results showed that the combination treatment improved PFS similarly for both mutation groups, indicating no significant difference in outcomes based on the type of genetic mutation (P=0.07, p=0.94).
Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth.
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