Forsythoside B Ameliorates Neuroinflammation via Inhibiting NLRP3 Inflammasome of Glial Cells in Experimental Autoimmune Encephalomyelitis Mice.

Neuroinflammation mediated by glial cells plays a crucial role in demyelination in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS) model. Forsythoside B (FTS·B), a natural phenylethanoid glycoside isolated from the dried fruits and leaves of Forsythia suspensa (Thunb.) Vahl, has been found to have antioxidant, anti-apoptotic, and anti-inflammatory properties.

Highly Hydrophilic and Defective Carbon Nitride for Enhanced Photocatalytic Hydrogen Evolution.

Graphitic carbon nitride (g-CN), as a kind of nonmetallic low-cost photocatalyst, has great potential in photocatalytic hydrogen (H) evolution, but its poor hydrophilicity and nonwetting extremely limit its H evolution efficiency. Herein, highly hydrophilic and defective g-CN photocatalysts (NH-CN-P as a representative example) have been fabricated on the basis of the strategy of joint phosphorus doping and ammonia stripping. The dopant of phosphorus prefers to occupy the C atoms bonded to -NH groups in the g-CN skeleton, which is conducive to the formation of N defects caused by the effects of electronegativity and charge balance.

T1-weighted images-based radiomics for structural lesions evaluation in patients with suspected axial spondyloarthritis.

Purpose: The aim of this study was to investigate the feasibility of radiomics based on T1-weighted images (T1WI) for assessing sacroiliac joint (SIJ) structural lesions in patients with suspected axial spondyloarthritis (axSpA).

Materials And Methods: A total of 266 patients with clinical suspicion of axSpA between December 2016 and January 2022 were enrolled. Structural lesions were assessed on low-dose CT (ldCT) and MRI, respectively.

Infant death prediction using machine learning: A population-based retrospective study.

Background: Despite declines in infant death rates in recent decades in the United States, the national goal of reducing infant death has not been reached. This study aims to predict infant death using machine-learning approaches.

Methods: A population-based retrospective study of live births in the United States between 2016 and 2021 was conducted.

HAbot: a human-centered augmented reality robot programming method with the awareness of cognitive load.

In the era of Industry 4.0, manufacturing enterprises are actively adopting collaborative robots (Cobots) in their productions. Current online and offline robot programming methods are difficult to use and require extensive experience or skills.

Can radiomics replace the SPARCC scoring system in evaluating bone marrow edema of sacroiliac joints in patients with axial spondyloarthritis?

Objectives: To develop an objective and efficient method based on radiomics to evaluate bone marrow edema (BMO) of sacroiliac joints (SIJs) by magnetic resonance imaging (MRI) in patients with axial spondyloarthritis (axSpA) and to compare with the Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system.

Methods: From September 2013 to March 2022, patients with axSpA who underwent 3.0T SIJ-MRI were included and were randomly divided into training and validation cohorts at a ratio of 7:3.

A predictive clinical-radiomics nomogram for diagnosing of axial spondyloarthritis using MRI and clinical risk factors.

Objectives: Construct and validate a nomogram model integrating the radiomics features and the clinical risk factors to differentiating axial spondyloarthritis (axSpA) in low back pain patients undergone sacroiliac joint (SIJ)-MRI.

Methods: A total of 638 patients confirmed as axSpA (n = 424) or non-axSpA (n = 214) who were randomly divided into training (n = 447) and validation cohorts (n = 191). Optimal radiomics signatures were constructed from the 3.

Identification of EMT-Related Gene Signatures to Predict the Prognosis of Patients With Endometrial Cancer.

Background: Endometrial cancer (EC) is one of the most common gynecological cancers. Epithelial-mesenchymal transition (EMT) is believed to be significantly associated with the malignant progression of tumors. However, there is no relevant study on the relationship between EMT-related gene (ERG) signatures and the prognosis of EC patients.

MRI compared with low-dose CT scanning in the diagnosis of axial spondyloarthritis.

Objectives: To compare the performance of conventional radiography, ldCT, and MRI in the diagnosis of sacroiliitis in suspected axial spondyloarthritis (axSpA).

Methods: Patients presenting with > 3 months chronic back pain were assessed by axSpA-experienced rheumatologists and diagnosed as axSpA or not; axSpA patients were then considered nr-axSpA or AS using plain radiography. Non-axSpA patients were recruited as controls, and divided into non-inflammatory and inflammatory groups on the basis of inflammatory back pain and/or CRP/ESR elevation.

Initial experience of generalized intravoxel incoherent motion imaging and diffusion tensor imaging (GIVIM-DTI) in healthy subjects.

Purpose: To evaluate the feasibility of combined generalized intravoxel incoherent imaging and diffusion tensor imaging (GIVIM-DTI) to access the renal microstructure and microcirculation with respiratory triggering.

Materials And Methods: A total of 28 young healthy volunteers with no history of renal disease were recruited into our study. GIVIM-DTI images were acquired with respiratory triggering at 3 Tesla.

Widespread and evolutionary analysis of a MITE family Monkey King in Brassicaceae.

Background: Miniature inverted repeat transposable elements (MITEs) are important components of eukaryotic genomes, with hundreds of families and many copies, which may play important roles in gene regulation and genome evolution. However, few studies have investigated the molecular mechanisms involved. In our previous study, a Tourist-like MITE, Monkey King, was identified from the promoter region of a flowering time gene, BnFLC.

Internal fixation with percutaneous kyphoplasty compared with simple percutaneous kyphoplasty for thoracolumbar burst fractures in elderly patients: a prospective randomized controlled trial.

Purpose: The impact of percutaneous internal fixation as a supplement to percutaneous kyphoplasty (PKP) for the management of thoracolumbar burst fractures in elderly patients is unclear. We conducted a clinical controlled trial to investigate the effect and outcomes of this technique in such patients.

Methods: Forty-three patients over 65 years old with thoracolumbar burst fractures without nerve injuries were enrolled.

A Tourist-like MITE insertion in the upstream region of the BnFLC.A10 gene is associated with vernalization requirement in rapeseed (Brassica napus L.).

Background: Rapeseed (Brassica napus L.) has spring and winter genotypes adapted to different growing seasons. Winter genotypes do not flower before the onset of winter, thus leading to a longer vegetative growth period that promotes the accumulation and allocation of more resources to seed production.