Effects of non-pharmacological interventions on sexual health in patients with breast cancer: A network meta-analysis.

Objective: This review systematically identifies and synthesizes evidence to examine the impact of non-pharmacological interventions on the sexual health of patients with breast cancer through a meta-analysis approach.

Methods: From establishment to December 2, 2024, eight electronic databases including PubMed, Embase, Web of Science, Cochrane, CNKI, VIP, Wanfang and Biomedical Literature Service System were searched. The inclusion criteria comprised randomized controlled trials (RCTs) of non-drug interventions, controlled clinical trials and quasi-experimental studies.

Identification of Host-Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells.

Canine Parvovirus (CPV) is a highly contagious virus that causes severe hemorrhagic enteritis and myocarditis, posing a major threat to the life and health of dogs. The molecular mechanism by which VP2, the major capsid protein of CPV, infects host cells and utilizes host cell proteins for self-replication remains poorly understood. In this study, 140 host proteins specifically binding to CPV VP2 protein were identified by immunoprecipitation combined with liquid chromatography-mass spectrometry (LC-MS/MS).

Enhanced validation and application of satellite-derived formaldehyde data for assessing photochemical pollution in the Chinese Greater Bay Area.

Formaldehyde (HCHO) is a key player in photochemical processes and serves as a crucial precursor in the formation of hydroxyl radicals and ozone (O). While satellite observations can offer extensive spatiotemporal distributions of HCHO at both global and regional scales, the reliability of these satellite-derived HCHO measurements remains uncertain. In this study, we generated a five-year (June 2018-May 2023) Level 3 HCHO dataset, by applying spatial averaging technique to the TROPOspheric Monitoring Instrument (TROPOMI) Level 2 data.

In-situ online investigation of biogenic volatile organic compounds emissions from tropical rainforests in Hainan, China.

Biogenic volatile organic compounds (BVOCs) emitted by tropical plants represent a significant proportion of global emissions, but the in-situ BVOC measurements in tropical rainforests are extremely sparse. Herein, a vehicle-mounted mobile monitoring system was developed for in-situ online investigations of BVOC emissions from thirty representative tree species in the tropical rainforests of Hainan Island, southern China. The results showed that monoterpenes were the primary BVOCs emitted from most broadleaf trees.

Development and validation of a UPLC-MS/MS method for rapid and simultaneous quantification of BPI-460372 and its metabolites BPI-460444 and BPI-460456 in human plasma.

In cancer development and progression, the Hippo signaling pathway functions. The transcriptional enhanced associate domain (TEAD) stands out as a pivotal transcription factor within this pathway, and the suppression of TEAD represents a promising approach for cancer treatment. The primary aim of the study was to establish an analytical method for the concurrent quantification of a novel TEAD target inhibitor, BPI-460372, and its principal metabolites, BPI-460444 and BPI-460456, in human plasma.

Complete chloroplast genome of endangered species Blume (Dipterocarpaceae) and its phylogenetic implications.

Blume is an endangered species on the IUCN Red List. In this study, we reported the complete chloroplast (cp) genome of (GenBank accession number: OP271853). The cp genome was 154,303 bp long, with a large single-copy (LSC) region of 85,586 bp and a small single-copy (SSC) region of 20,273 bp separated by a pair of inverted repeats (IRs) of 24,222 bp.

Mechanism of probiotics in the intervention of colorectal cancer: a review.

The human microbiome interacts with the host mainly in the intestinal lumen, where putrefactive bacteria are suggested to promote colorectal cancer (CRC). In contrast, probiotics and their isolated components and secreted substances, display anti-tumor properties due to their ability to modulate gut microbiota composition, promote apoptosis, enhance immunity, resist oxidation and alter metabolism. Probiotics help to form a solid intestinal barrier against damaging agents via altering the gut microbiota and preventing harmful microbes from colonization.

Solvent-Regulated Formation of Metal/Metal-Oxo Nodes in Two Indium Metal-Organic Frameworks: Syntheses, Structures, Selective Gas Adsorption and Fluorescence Sensor Properties.

Two water-stable indium metal-organic frameworks, (NHMe)[In(BTB)] ⋅ 12DMA ⋅ 4.5HO (In-MOF-1) and (NHMe)[InO(BTB)(HO)(DMSO)] ⋅ 27DMSO ⋅ 21HO (In-MOF-2) (BTB=4,4',4''-benzene-1,3,5-tribenzoate) with 3D interpenetrated structure has been constructed by regulating solvents. Structure analysis revealed that In-MOF-1 has a three-dimensional (3D) structure with a single metal core, while In-MOF-2 features an octahedron cage constructed by three kinds of metal clusters to further form a 3D structure.

Emission characteristics of biogenic volatile organic compounds in a subtropical pristine forest of southern China.

Emission characteristics of biogenic volatile organic compounds (BVOCs) from dominant tree species in the subtropical pristine forests of China are extremely limited. Here we conducted in situ field measurements of BVOCs emissions from representative mature evergreen trees by using dynamic branch enclosures at four altitude gradients (600-1690 m a.s.

ERCP-Related adverse events in pediatric patients: a 10-years single-site review.

Purpose: This retrospective analysis aimed to assess the feasibility and safety of endoscopic retrograde cholangiopancreatography (ERCP) in pediatric patients by examining ERCP-related adverse events (AEs) occurring over a decade at a single center.

Methods: Pediatric patients under 18 years old who underwent ERCP at the Second Hospital of Hebei Medical University from 1/2013 to 11/2023 were included. ERCP-related AEs were defined according to ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Comprehensive measurement of carbonyls in Lhasa, Tibetan Plateau: Implications for strong atmospheric oxidation capacity.

Carbonyls are ubiquitous in the troposphere and play a crucial role in atmospheric oxidation capacity (AOC), particularly in photochemistry-active regions such as the Tibetan Plateau (TP). However, the composition and evolution of carbonyls over the TP is still poorly understood due to a lack of comprehensive observations and modelling. Here, we conducted an intensive field measurement of 37 carbonyls and their precursors at a suburban site in Lhasa during summer 2022.

Comparative chloroplast genomes of species: genome evolution and phylogenomic implications.

The genus Hill belongs to the tribe Potentilleae Sweet and contains approximately 75 species predominantly distributed in the Sino-Himalayan region and the Malesian archipelago. So far we have less knowledge on the phylogenetic relationships within owing to limited sampling of taxa or gene fragments in previous studies. Moreover, to date there is no phylogenetic study on from the perspective of comparative chloroplast (cp) genomics.

Origins of formaldehyde in a mountainous background atmosphere of southern China.

Formaldehyde (HCHO) is one of the key indicators of severe photochemical pollution and strong atmospheric oxidation capacity in southern China. However, current information on the origins of regional HCHO and the impacts of polluted air masses remains scarce and unclear. In this study, an intensive observation of HCHO was conducted at a mountainous background site in southern China during typical photochemical pollution episodes.

Photochemical loss with consequential underestimation in active VOCs and corresponding secondary pollutions in a petrochemical refinery, China.

The photochemical loss of volatile organic compounds (VOCs) significantly alters the capturing source profiles in high-reactivity VOC species and results in an underestimation of secondary pollutants such as ozone (O) and secondary organic aerosol (SOA). Utilising speciated VOC data from large petrochemical refineries, the research assesses the photochemical loss of various VOC species. Air samples from multiple sites revealed over 99 VOCs, with initial concentrations estimated via a photochemical age-based parameterisation method.

Sources of elevated organic acids in the mountainous background atmosphere of southern China.

Formic acid (FA) and acetic acid (AA) are pivotal organic acids in the troposphere, significantly influencing atmospheric chemistry. However, their abundance and sources in the mountainous background atmosphere remain underexplored. We undertook continuous measurements of FA and AA in Nanling mountains, southern China, during autumn 2020 using a high-resolution time-of-flight chemical ionization mass spectrometer (HR-ToF-CIMS).

Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone.

The Kv4.3 channel features fast N-type inactivation and also undergoes a slow C-type inactivation. The gain-of-function mutations of Kv4.

Lusianthridin ameliorates high fat diet-induced metabolic dysfunction-associated fatty liver disease via activation of FXR signaling pathway.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease, but there are few specific medications for it. Lusianthridin, a major phenanthrene component that originates from Dendrobium Sonia, has various in vitro biological functions. In this study, we aimed to evaluate the therapeutic effects of lusianthridin on high-fat diet (HFD)-induced MAFLD as well as to examine the mechanism of its effects.

Plastid phylogenomics of the tribe potentilleae (Rosaceae).

The tribe Potentilleae comprises approximately 1700 species in 13 genera, making it one of the largest of the 16 tribes in Rosaceae. Our understanding of the composition and relationships among members of Potentilleae has advanced dramatically with the application of molecular markers in the last two decades. Yet there is still much work remaining toward a robust phylogenetic framework for the entire Potentilleae and a comprehensive genus-level dating framework for the tribe.

The complete chloroplast genome of (Maxim.) Smedmark 2006 (Rosaceae: Colurieae) and its phylogenomic implications.

(Maxim.) Smedmark 2006 belongs to the family Rosaceae, subfamily Rosoideae, tribe Colurieae. is endemic to China and its whole herb is used in Chinese medicine.

Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review.

Alzheimer's disease (AD) is a complex neurodegenerative disease. Despite several decades of research, the development of effective treatments and responses for Alzheimer's disease remains elusive. The utilization of polysaccharides for Alzheimer's disease became more popular due to their beneficial characteristics, notably their multi-target activity and low toxicity.

Tibetan Plateau is vulnerable to aromatic-related photochemical pollution and health threats: A case study in Lhasa.

Anthropogenic aromatics play a key role in photochemical pollution and pose a serious threat to human health. Current knowledge on source characteristics of aromatics in the urban region of the Tibetan Plateau (TP), the "Third Pole" and ecologically sensitive area, remains limited. In this study, an intensive observation of 17 aromatic hydrocarbons was conducted in Lhasa, the cultural and economic center of TP, during the second Tibetan Plateau Scientific Expedition and Research in summer 2020.

Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification.

Background: As digital medicine has exerted profound influences upon diagnosis and treatment of hepatobiliary diseases, our study aims to investigate the accuracy of three-dimensional visualization and evaluation (3DVE) system in assessing the resectability of hilar cholangiocarcinoma (hCCA), and explores its potential clinical value.

Materials And Methods: The discovery cohort, containing 111 patients from April 2013 to December 2019, was retrospectively included to determine resectability according to revised criteria for unresectability of hCCA. 3D visualization models were reconstructed to evaluate resectability parameters including biliary infiltration, vascular involvement, hepatic atrophy and metastasis.

Case report: Prenatal diagnosis of rare chromosome mosaicism: discordant results between chorionic villi and amniotic fluid samples.

We described a unique case of near-negative chromosome mosaicism in chorionic villi but complete monosomy X in amniotic fluid. Chorionic villus sampling and amniocentesis were performed separately in the first and second trimesters. Chromosomal microarray (CMA) and rapid aneuploidy detection (QF-PCR and FISH) were performed on placental villi and uncultured amniotic fluid.