Development and field evaluation of a novel sugar bait device for controlling residential vector mosquitoes in Zhejiang Province, China.

Background: Mosquito-borne diseases pose serious public health threats in Zhejiang Province, China, and vector control is believed to be the primary method for reducing transmission. Due to severe resistance problems, effective and sustainable methods without chemical insecticides are urgently required to control mosquito vectors. Attractive toxic sugar baits (ATSB) are newly developed methods to control mosquitoes in recent decades with the core element sugar bait, which was invented according to the sugar-feeding behavior of mosquitoes.

The ecological and etiological investigation of ticks and rodents in China: results from an ongoing surveillance study in Zhejiang Province.

Objectives: This study aimed to analyze the population density of vector ticks and reservoir hosts rodents, and to investigate the relevant pathogen infection in Zhejiang Province, China.

Methods: In this surveillance study, the data of ticks density were collected with the tick picking method on animal body surface and the drag-flag method, while the rodent density with the night trapping method. The samples of ticks were examined for the severe fever with thrombocytopenia syndrome virus (SFTSV), and blood serum and organs from rodents were subjected for SFTSV, hantavirus, , () and () screening in the laboratory.

A Review of Pathogens Transmitted by the Container-Inhabiting Mosquitoes, Aedes Albopictus, A Global Public Health Threat.

Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV) are highly pathogenic human arboviruses transmitted by the or mosquito. These arboviruses are responsible for causing fever, hemorrhagic conditions, and neurological diseases in humans post-bite from an infected mosquito. Over the past 80 years, the has infested every habitable continent, bar Antarctica, thereby escalating the probability of global insect-borne infectious disease outbreaks.

Evaluation of the effectiveness of the human-baited double net traps and BG traps compared with the human landing catches for collecting outdoor Aedes albopictus in China.

Dengue fever is one of the biggest threats to public health in China, causing huge disease burden and economic loss. Aedes-mosquito surveillance could be a cornerstone for predicting the risk of Aedes-borne diseases and evaluating the effect of vector management during diseases outbreaks. The human landing catch (HLC) method is regarded as the "gold standard" for catching Aedes mosquitoes, but it potentially exposes field professionals to vectors of known or unknown pathogens.

Practice of integrated vector surveillance of arthropod vectors, pathogens and reservoir hosts to monitor the occurrence of tropical vector-borne diseases in 2020 in Zhejiang Province, China.

Background: Vector-borne diseases have become one of the most serious local public health threats. Monitoring and controlling vectors are important means of controlling vector-borne diseases. However, traditional vector surveillance systems in China mainly monitor vector density, making its early-warning effect on vector-borne diseases weak.

A Review of the Surveillance Techniques for Aedes albopictus.

Aedes (Stegomyia) albopictus (Skuse) (Diptera: Culicidae) transmits a variety of arboviruses (arthropod-borne viruses) and acts as one of the most dangerous mosquito species in the world. Mosquito surveillance is the main means of evaluating vector density, vector-borne disease risk, and the efficacy of vector-control operations. The larval density of Ae.

Screening and analysis of immune-related genes of Aedes aegypti infected with DENV2.

Dengue virus type Ⅱ (DENV2) is a primary serotype responsible for the dengue fever epidemic, and Aedes aegypti is the main DENV2 vector. Understanding the Aedes aegypti immune mechanism against DENV2 is the basis for research on immune blockade in mosquitoes. Some preliminary studies lack validation in the literature, so this study was performed to further study and validate the potential target genes to provide a further basis for screening key target genes.

Fine-scale genetic structure and infection of (Diptera: Culicidae) in Nanjing city, China.

is an indigenous primary vector of dengue and Zika viruses in China. is a gram-negative and common intracellular bacteria, which is maternally inherited endosymbionts and could expand their propagation in host populations by means of various manipulations. Compared with research on the dispersion of at the macrospatial level (mainly at the country or continent level), little is known about its variation and infection at the microspatial level, which is essential for its management.

Entomological Investigation and Detection of Dengue Virus Type 1 in (Skuse) During the 2018-2020 Outbreak in Zhejiang Province, China.

Mosquito-borne diseases are still threats to public health in the Zhejiang province of China. Surveillance of mosquitoes and the mosquito-borne pathogen is a vital approach for early warning, prevention, and control of the infectious disease. In this study, from 2018 to 2020, a total of 141607 female mosquitoes were caught by means of the light trap method.

From SARS to the Omicron variant of COVID-19: China's policy adjustments and changes to prevent and control infectious diseases.

The COVID-19 pandemic has been the biggest public health crisis in a century. Since it was initially reported in 2019, the duration and intensity of its impacts are still in serious question around the world, and it is about to enter its third year. The first public health revolution failed to achieve its ultimate targets, as previously contained infectious diseases seem to have returned, and new infectious diseases continue to emerge.

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome.

Severe fever with thrombocytopenia syndrome (SFTS) is a disease caused by infection with the SFTS virus (SFTSV). SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. Evidence suggests that SFTSV circulates between ticks and animals in nature and is transmitted to humans by tick bites.

Update on the use of sildenafil in neonatal pulmonary hypertension: a narrative review of the history, current administration, and future directions.

Pulmonary hypertension (PH) is a life-threatening syndrome in neonates and has multiple and varied etiologies. However, few clinical studies have systematically evaluated the treatment regimens for this population. Phosphodiesterase (PDE) inhibitors, such as milrinone, tadalafil, dipyridamole, and sildenafil, are the most important regulators of vascular relaxation in the normal pulmonary vascular transition after birth, and these agents are widely used in the treatment of PH.

Field evaluation of two mosquito traps in Zhejiang Province, China.

Mosquito-borne Diseases are a common but severe public health threat. However, there is a lack of consensus on the effect of different mosquito trapping devices in China. This study firstly compared the BGM trap with the CDC light trap, commonly used in Chinese mosquito surveillance.

Effect of different carbon dioxide (CO2) flows on trapping Aedes albopictus with BG traps in the field in Zhejiang Province, China.

Carbon dioxide (CO2) attracts host-seeking adult mosquitoes; this fact is exploited for mosquito monitoring, which is important for evaluating the effects of mosquito-control operations. A field experiment was designed to explore the relationship between the CO2 flow rate and the trapping effect of BG traps. The aim was to select an appropriate flow rate for monitoring Aedes albopictus.

Susceptibility of Armigeres subalbatus Coquillett (Diptera: Culicidae) to Zika virus through oral and urine infection.

Background: Zika virus (ZIKV) disease outbreaks have been occurring in South America since 2015, and has spread to North America. Because birth defects and cases of Guillain Barré have been associated with infection with ZIKV, this has drawn global attention. ZIKV is generally considered an Aedes-transmitted pathogen.

Insecticide Resistance of Aedes albopictus in Zhejiang Province, China.

From 2003 until 2018, a total of 12 outbreaks with 1,654 confirmed dengue cases have been reported in Zhejiang Province. The emergence of insecticide resistance in mosquitoes will affect the control of dengue. Our study aims to investigate the current situation of insecticide resistance of Ae.

Relationships between traditional larval indices and meteorological factors with the adult density of Aedes albopictus captured by BG-mosquito trap.

Objectives: Larval indices have been used for Ae. albopictus surveillance for many years, while there is limited use in assessing dengue transmission risk and adult mosquito emergence. This study is aimed to explore the relationships between larval indices and the Ae.

RNA interference of odorant receptor CquiOR114/117 affects blood-feeding behavior in Culex quinquefasciatus.

The odorant receptors (ORs) play a critical role for mosquitoes in the identification of blood-feeding hosts and other physiological processes. The OR8 subfamily in mosquitoes has been shown to be strongly involved in the detection the mammalian host associated odor, 1-octen-3-ol. CquiOR114/117 has been shown to be an orthologous OR8 in Culex quinquefasciatus Say.

Vector Competence and Vertical Transmission of Zika Virus in (Diptera: Culicidae).

Zika virus (ZIKV) is an emerging mosquito-borne pathogen belonging to the genus of the family . is widely distributed in China. However, little is known about the vector competence of in China.

Resistance of House Fly, L. (Diptera: Muscidae), to Five Insecticides in Zhejiang Province, China: The Situation in 2017.

Objectives: High dependency on pesticides could cause selection pressure leading to the development of resistance. This study was conducted to assess the resistance of the house fly, , to five insecticides, namely, permethrin, deltamethrin, beta-cypermethrin, propoxur, and dichlorvos, in Zhejiang Province.

Methods: Field strains of house flies were collected from the 12 administrative districts in Zhejiang Province in 2011, 2014, and 2017, respectively.

Role of Nrf2 and Its Activators in Respiratory Diseases.

Transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant response element- (ARE-) driven cytoprotective protein expression. The activation of Nrf2 signaling plays an essential role in preventing cells and tissues from injury induced by oxidative stress. Under the unstressed conditions, natural inhibitor of Nrf2, Kelch-like ECH-associated protein 1 (Keap1), traps Nrf2 in the cytoplasm and promotes the degradation of Nrf2 by the 26S proteasome.

Screening for differentially expressed miRNAs in Aedes albopictus (Diptera: Culicidae) exposed to DENV-2 and their effect on replication of DENV-2 in C6/36 cells.

Background: The mosquito Aedes albopictus is an important vector for dengue virus (DENV) transmission. The midgut is the first barrier to mosquito infection by DENV, and this barrier is a critical factor affecting the vector competence of the mosquito. However, the molecular mechanism of the interaction between midgut and virus is unknown.

Identification of Differentially Expressed Genes In Deltamethrin-Resistant Culex pipiens quinquefasciatus.

Culex quinquefasciatus is one of China's major house-dwelling mosquito species and an important vector of filariasis and encephalitis. Chemical treatments represent one of the most successful approaches for comprehensive mosquito prevention and control. However, the widespread use of chemical pesticides has led to the occurrence and development of insecticide resistance.