Naunyn Schmiedebergs Arch Pharmacol
January 2025
To investigate the effect of icariin (ICA) on hepatocellular carcinoma (HCC) and its autophagy/apoptosis mechanism in HCC. The anti-HCC mechanism of ICA was investigated using HCC cells treated with 20 µmol/L ICA. Cell viability and proliferation were assessed using CCK-8 and colony formation assays, respectively, while TUNEL staining evaluated anti-apoptotic effects.
View Article and Find Full Text PDFOrganic Ultraviolet Filters (OUVFs), commonly used in sunscreens, cosmetics and industrial products to prevent ultraviolet radiation damage, are increasingly detected in the environment due to their widespread use and persistence. This has raised concerns over their toxicity and environmental impact, leading to the classification of OUVF 2-(2H-Benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328) as a persistent organic pollutant under the Stockholm Convention in 2023. In this review, current knowledge on the usage, discharge and environmental contamination of OUVFs is briefly discussed.
View Article and Find Full Text PDFDysfunction of the ubiquitin‒proteasome system can induce sustained endoplasmic reticulum stress (ERS) and subsequent cell death. However, malignant cells have evolved multiple mechanisms to evade sustained ERS. Therefore, identification of the mechanisms through which tumor cells develop resistance to ERS is important for the therapeutic exploitation of these cells for drug-resistant tumors.
View Article and Find Full Text PDFIt has become increasingly clear that microRNAs play an important role in many human diseases including cancer. Here, we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family, member B (RhoB) expression. miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity, but the inhibitory effect was lost when the putative target sites were mutated.
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