Publications by authors named "Qinjun Xie"
Br J Cancer
November 2024
Article Synopsis
- Epithelial ovarian cancer (EOC) is a challenging and deadly type of gynecological cancer, with a need for clearer understanding of its molecular subtypes and treatment options.
- Mass spectrometry-based proteomics and single-cell RNA sequencing analyses revealed four distinct EOC proteomic subtypes that have unique clinical implications: malignant proliferative, immune infiltrating, Fallopian-like, and differentiated.
- The immune infiltrating subtype (C2) shows potential for improved prognosis through therapies targeting CD40, while a specific therapeutic pathway involving a TYMP inhibitor was found to be effective for patients with non-immune EOC subtypes.
