Lung and Cutaneous Abscesses in a Patient with Ulcerative Colitis: A Case Report and Literature Review.

Aseptic abscess (AA) syndrome is a rare inflammatory disorder often associated with inflammatory bowel disease (IBD). Cases of IBD-associated AA have been reported in Japan, India, and Canada, but rarely in China. Herein, we present the case of a Chinese patient with IBD-associated AAs and review the literature on AA with underlying IBD.

Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex.

Chronic pain is a complex disease. It seriously affects patients' quality of life and imposes a significant economic burden on society. Santacruzamate A (SCA) is a natural product isolated from marine cyanobacteria in Panama.

Linderane Attenuates Complete Freund's Adjuvant-Induced Pain and Anxiety in Mice by Restoring Anterior Cingulate Cortex Microglia M2 Polarization through Activating Cannabinoid 2 Receptor.

Chronic pain is a common condition that causes negative emotions as the disease progresses. The anterior cingulate cortex (ACC) is a key region in the integration of nociceptive perception and emotional response in chronic pain. Linderane (LDR) is an active ingredient from , a traditional Chinese medicine with anti-inflammatory, analgesic, and antibacterial properties.

Evaluation of left ventricular stiffness with echocardiography.

Half of patients with heart failure are presented with preserved ejection fraction (HFpEF). The pathophysiology of these patients is complex, but increased left ventricular (LV) stiffness has been proven to play a key role. However, the application of this parameter is limited due to the requirement for invasive catheterization for its measurement.

Case report: cerebral venous sinus thrombosis and pulmonary embolism as the initial presentation in a child with asymptomatic primary nephrotic syndrome.

Background: Cerebral venous sinus thrombosis (CVST) is rare, but potentially life-threatening. The clinical course definitely become more unpredictable and fatal in patients complicated by pulmonary embolism (PE). Nephrotic syndrome (NS) is an uncommon etiology of CVST.

Ceftazidime-Avibactam Treatment for Severe Post-Neurosurgical Meningitis and Abscess Caused by Extended-Spectrum β-Lactamase in a Pediatric Patient: A Case Report.

Post-neurosurgical infections caused by multidrug-resistant Enterobacterales are difficult to treat due to limited therapeutic options. Ceftazidime-avibactam (CAZ-AVI), a combination of cephalosporin and a novel β-lactamase inhibitor, has exhibited potential activity against multi/extensive drug-resistant (MDR/XDR) gram-negative bacilli. Several reports have described the successful treatment of central infections caused by MDR/XDR or Enterobacterales.

Pyrolysis of a typical low-rank coal: application and modification of the chemical percolation devolatilization model.

The chemical percolation devolatilization (CPD) model can simulate the formation of various products during the coal pyrolysis process and predict the products composition relatively accurately. In this study, the pyrolysis products of a typical low-rank coal were calculated using the CPD model, and several model improvements were proposed by combining the experimental results in a lab-scale pyrolysis system. The chemical structural parameters calculated from the Genetti correlations were verified by adjusting the initial fraction of char bridges ( ) from 0.

Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome colonic mast cell activation and central 5-hydroxytryptamine metabolism.

Irritable bowel syndrome (IBS) is a common chronic functional bowel disease, associated with a high risk of depression and anxiety. The brain-gut axis plays an important role in the pathophysiological changes involved in IBS; however, an effective treatment for the same is lacking. The natural compound costunolide (COS) has been shown to exert gastroprotective, enteroprotective, and neuroprotective effects, but its therapeutic effects in IBS are unclear.

Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH/eNOS to Improve Intestinal Ischemia.

There is a high incidence of radiation enteritis (RE) after abdominal radiotherapy. The occurrence of RE seriously affects the treatment and quality of life of patients; however, its pathogenesis is complex and there are no effective drugs for its prevention or treatment. Intestinal ischemia plays an important role in the occurrence of enteritis.

Thermodynamic and Economic Analysis of Oxy-Fuel-Integrated Coal Partial Gasification Combined Cycle.

A novel partial gasification combined cycle (PGCC) system integrating coal partial gasification, oxy-fuel combustion, combined cycle, and CO separation is proposed. The coal-CO partial gasification technology is introduced in the coal gasification unit, and the oxy-fuel combustion technology is employed in the char combustion unit and gas turbine (GT) unit. The thermodynamic and economic analysis of the proposed system is carried out, showing that both energy and exergy efficiency have an increasing/decreasing tendency when the recycled flue gas (RFG) ratio of char combustion and GT increase.

Aerosol Emissions of Amine-Based CO Absorption System: Effects of Condensation Nuclei and Operating Conditions.

Amine emissions from a post-combustion CO capture process can lead to solvent loss and serious environmental issues. The emission characteristics of amine mixtures and influencing factors are seldom reported. This work comprehensively investigated emissions of AMP (2-amino-2-methyl-1-propanol)/MEA (monoethanolamine) from a 3.

Ionizing radiation induces BH deficiency by downregulating GTP-cyclohydrolase 1, a novel target for preventing and treating radiation enteritis.

Radiation enteritis (RE) is a common side effect after radiotherapy for abdominal cancer. RE pathogenesis is complicated, with no drugs available for prevention or treatments. Intestinal ischemia is a key factor in the occurrence and development of enteritis.

Glycyrrhetinic acid attenuates disturbed vitamin a metabolism in non-alcoholic fatty liver disease through AKR1B10.

Abnormal vitamin A (retinol) metabolism plays an important role in the occurrence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, NAFLD and NASH models were established to investigate the effects of food additives glycyrrhizic acid (GL) on retinol metabolism in NAFLD/NASH mice. Potential targets of GL and its active metabolite glycyrrhetinic acid (GA) were analyzed by RNA sequence, bioinformatics, and molecular docking analyses.

Remarks on "Comments on 'Effect of hydrolysed cellulose nanowhiskers on properties of montmorillonite/polylactic acid nanocomposites' By Reza Arjmandi et al." By Djalal Trache.

The Coats-Redfern method is commonly used to calculate the activation energy of the thermal degradation from a single non-isothermal thermogravimetric curve since its first proposal in 1964. This paper represents the accurate expressions, sound derivation process and proper usage of the Coats-Redfern equations, based on the critique into the Coats-Redfern's original article, Djalal Trache's incorrect comments on Reza Arjmandi et al.'s article, and the flaw in Reza Arjmandi et al.

Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.

The herb couple has special clinical significance in reducing the toxicity and increasing the efficacy of drugs. The combination of Radix Angelicae Dahuricae (Baizhi, BZ) and Rhizoma Chuanxiong (ChuanXiong, CX) is a traditional herb couple. The combination performs better than the CX extract alone in the treatment of migraine and has been used for thousands of years.

Simulation of nitrogen transformation in pressurized oxy-fuel combustion of pulverized coal.

Chemical kinetic modeling was applied to simulate N transformation in the pressurized oxy-fuel combustion process of pulverized coal. Modeling accuracy was validated by experimental data at different operation pressures. The key reaction paths from fuel-N to different N products were revealed by analyzing the rate of production.

Ash deposition behavior of a high-alkali coal in circulating fluidized bed combustion at different bed temperatures and the effect of kaolin.

High alkali and alkali earth metals (AAEMs) content in coal causes severe slagging and fouling during combustion in a boiler. In this study, the ash deposition behavior of a high-alkali coal at different bed temperatures and the effect of kaolin were investigated in a 30 kW circulating fluidized bed (CFB) test system using an ash slagging probe and deposition probe. The results show that the ash deposition tendency increases with the bed temperature.

A study on the preparation of pitch-based high-strength columnar activated carbon and mechanism of phenol adsorption from aqueous solution.

Coal tar pitch was ground into powder and hydroformed with high pressure. After pre-oxidation, the pitch was activated by CO at high temperature. The effects of different preparation conditions on the yield, pore structure and phenol adsorption capacity of activated carbon were investigated, and activated carbon prepared under suitable conditions had good adsorption performance.

Metabolic profile of danshen in rats by HPLC-LTQ-Orbitrap mass spectrometry.

Danshen, the dried root of Salvia miltiorrhiza Bunge (Lamiaceae), is one of the traditional Chinese medicines (TCMs) most commonly used for the treatment of cardiovascular and cerebrovascular diseases. However, little is known about the chemical and metabolic profiles of danshen in vitro or in vivo. In particular, more information is needed in relation to the 50% ethanol extracts usually used in danshen formulations such as Fufang Xueshuantong Capsules and Fufang Danshen tablets.

[Distribution of chemical compounds of Fufang Xueshuantong capsule in eyes and kidney of beagle dogs].

Diabetic retinopathy(DR) and diabetic nephropathy(DN) are the most common complications of diabetes, and the main causes of death and disability of diabetes. Clinical reports showed that Fufang Xueshuantong capsule(FXT) had effective curative effect on DR and DN, but there was no report on the distribution of chemical compounds of FXT in beagle dog eyes and kidneys. In this study, FXT was given by gavage administration in Beagle dogs for 3 days, and then their eyeballs and kidneys were taken.

[Phenanthrenes from aerial part of Juncus setchuensis with anxiolyticactivity].

Ten phenanthrenes, two organic acids, one organic acid ester and one flavonoid were isolated from the aerial part of Juncus setchuensis by various chromatographic techniques usingsilica gel, polyamide, Sephadex LH-20 as solid phases, and preparative HPLC. Their structures were identified by MS and NMR spectroscopic data as effusol(1), juncusol(2), juncuenin D(3), dehydroeffusol(4), dehydrojuncusol(5), juncuenin B(6),dehydrojuncuenin B(7), 2-methoxyl-7-hydroxyl-1-methyl-5-vinyl phenanthrene(8), 2-hydroxyl-7-carboxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene(9), 2-hydroxyl-7-carboxyl-1-methyl-5-vinylphenanthrene(10), luteolin(11), vanillic acid(12), daphnetin(13), p-coumaric acid(14), respectively. Compound 13 was isolated from the genus Juncus for the first time and compounds 5, 8-12 were isolated from J.

[LC-LTQ-Orbitrap analysis on chemical constituents in Scrophulariae Radix extract and their metabolites in rat plasma].

Chemical constituents in extract of Scrophulariae Radix and their metabolites in rat plasma after oral administration were identified by HPLC-LTQ-Orbitrap. Samples were separated by a Venusil MP C₁₈ column using a binary gradient elution. The information on the total ion chromatogram, the extraction chromatogram and the mass spectrogram in a negative mode were synthetically analyzed by comparing the retention time, MS and MS/MS spectra with literature data and some of reference standards to conduct a qualitative study on constituents of Radix Scrophulariae extract in vivo and in vitro.

Investigating herb-herb interactions: the potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizoma (Gancao) and Sophorae flavescentis radix (Kushen).

Ethnopharmacological Relevance: Glycyrrhizae radix et rhizoma (Gancao) is often prescribed together with Sophorae flavescentis radix (Kushen) in traditional Chinese medicinal practice to increase the efficacy on the treatment of hepatitis and hepatic fibrosis. Meanwhile, long-term single used Gancao can cause adverse reactions, lead to pseudohypercorticosteroidism especially. But the side effects of Gancao are significantly reduced when combined with Kushen; the reasons are still unknown.

Pharmacokinetic study of multiple active constituents from Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS.

Kushen-Gancao Decoction (KGD) is a classic traditional Chinese herb combination in treating viral hepatitis and chronic liver diseases. This study aims to investigate the pharmacokinetic (PK) study of matrine (MT), oxymatrine (OMT), glycyrrhizic acid (GL) and glycyrrhetinic acid (GA) following oral administration of KGD in rats. A rapid, sensitive and reliable HPLC-MS/MS method was successfully developed for the simultaneous determination of MT, OMT, GL and GA in rat plasma.