Publications by authors named "Qinhua Hu"

The COVID-19 pandemic continues to wreak havoc on the world's population's health and well-being. Successful screening of infected patients is a critical step in the fight against it, with radiology examination using chest radiography being one of the most important screening methods. For the definitive diagnosis of COVID-19 disease, reverse-transcriptase polymerase chain reaction remains the gold standard.

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Computer vision systems have numerous tools to assist in various medical fields, notably in image diagnosis. Computed tomography (CT) is the principal imaging method used to assist in the diagnosis of diseases such as bone fractures, lung cancer, heart disease, and emphysema, among others. Lung cancer is one of the four main causes of death in the world.

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Metastasis in lung cancer portends a poor prognosis, and the epithelial-mesenchymal transition (EMT) in lung cancer cells is considered a prerequisite to achieve metastatic potential. Recent studies indicate that BTB/POZ domain-containing protein 7 (BTBD7) regulates EMT-associated proteins in human malignancies and however, the role of BTBD7 in lung cancer have not been identified. In present study, we examined BTBD7 expression status and its association with unfavorable clinical features in non-small-cell lung cancer (NSCLC).

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Article Synopsis
  • Leucyl-tRNA synthetases (LeuRSs) are essential for attaching leucine to its corresponding tRNA, consisting of a catalytic domain for aminoacylation and a CP1 editing domain.
  • The CP1 domain must swing to connect with the aminoacylation domain, and its structure, particularly the CP1 hairpin, plays a vital role in this movement and their interaction.
  • Deleting or substituting the CP1 hairpin in human LeuRS resulted in loss of key functions like tRNA binding, while the hairpin from yeast LeuRS could partially restore function, highlighting the importance of specific amino acids in maintaining LeuRS's activity.
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Objective: To investigate if the interaction between TGF-beta1/Smad pathway and ERK pathway in vascular smooth muscle cells exists.

Methods: The rat arota was removed. The primary VSMC were isolated and cultured in vitro, then the VSMC were divided into four groups: (1) control group, (2) (TGF-beta1 group, (3) ERK blocking agent group, (4) TGF-beta1 + ERK blocking agent group.

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