ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition.

In our previous multicenter study, we delineated the inherent metabolic features of colorectal cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase/ phosphodiesterase family (ENPP2) as a significant differential metabolite of CRC. In this study, the role of ENPP2 in CRC has been demonstrated using established in vitro and in vivo models including ENPP2 gene knockdown, and use of the ENPP2 inhibitor, GLPG1690.

ASU-Net++: A nested U-Net with adaptive feature extractions for liver tumor segmentation.

Locating tumors from medical images is of high importance in medical analysis and diagnosis. To tackle the complicated shape of tumors, we propose a multi-leves.l feature extraction neural network to automatically segment the data.