Integrated serum pharmacochemistry and serum pharmacology to investigate the active components and mechanism of Bushen Huoxue Prescription in the treatment of diabetic retinopathy.

This study aimed to investigate the active components of Bushen Huoxue Prescriptions (BHP), and further clarify the mechanism by the integration of serum pharmacochemistry and serum pharmacology based on spectrum-effect relationship in vivo. In this paper, the components absorbed into serum were analyzed by ultra-high performance liquid chromatography-quadrupole-Exactive Orbitrap-high resolution mass spectrometry (UPLC-Q-Exactive Orbitrap-HRMS). And Müller cells were chosen as target cells to further investigate the mechanism.

Exploring the quality markers and mechanism of Bushen Huoxue Prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy.

Ethnopharmacological Relevance: Chinese herbal medicines have complex chemical composition; therefore, revealing the effective substances of Chinese herbal medicine becomes a prerequisite for scientific elucidation of the mechanism of action of Bushen Huoxue Prescription (BHP) against diabetic retinopathy (DR) and the development of new drugs.

Aim Of The Study: The Chinmedomics technique was used to evaluate the pharmacodynamic ingredients and mechanism of action of BHP against DR rats.

Materials And Methods: The overall physiological condition of the rats, including body weight, blood glucose, inflammatory factor levels, histological staining, and urine metabolic profile were examined to evaluate the model and its effects.

Removal of EMG Artifacts from Multichannel EEG Signals Using Combined Singular Spectrum Analysis and Canonical Correlation Analysis.

Electroencephalography (EEG) signals collected from human scalps are often polluted by diverse artifacts, for instance electromyogram (EMG), electrooculogram (EOG), and electrocardiogram (ECG) artifacts. Muscle artifacts are particularly difficult to eliminate among all kinds of artifacts due to their complexity. At present, several researchers have proved the superiority of combining single-channel decomposition algorithms with blind source separation (BSS) to make multichannel EEG recordings free from EMG contamination.

Accelerated oxidation of 2,4,6-trichlorophenol in Cu(II)/HO/Cl system: A unique "halotolerant" Fenton-like process?

The roles of chloride in enhanced oxidative degradation of refractory organic pollutants are recently identified in the Cu(II)/HO/Cl system, but the identity of the reactive oxidants and potential conversion of inorganic chloride to organochlorine in such oxidizing environment remain obscure. Here we report that Cu(II)/HO/Cl system is a unique "halotolerant" Fenton-like process that works most efficiently in saline water among the five tested redox-active metals ions (i.e.

An often-overestimated adverse effect of halides in heat/persulfate-based degradation of wastewater contaminants.

Halides (X) in the industrial wastewater are usually thought to adversely affect the degradation kinetics and mineralization rates in several SO-based advanced oxidation processes. However, their unfavorable effects might be overestimated, particularly the heat/persulfate (PS) system as tested in the present study. Here the degradation of phenol, benzoic acid, coumarin and acid orange 7 (AO7) was examined with the presence of chloride or bromide in a heat/PS process.

Chlorine incorporation into dye degradation by-product (coumarin) in UV/peroxymonosulfate process: A negative case of end-of-pipe treatment.

Recently, UV/peroxymonosulfate (PMS) seems as a panacea for the treatment of recalcitrant organic pollutants; however, the presence of high concentration of chloride in saline wastewater indeed complicates this end-of-pipe technology. Here a negative case of UV/PMS for the treatment of one of secondary degradation byproducts of dyes (coumarin, COU) is demonstrated. The removal rate of COU is reduced by addition of Cl (0-10 mM).

Deciphering the degradation/chlorination mechanisms of maleic acid in the Fe(II)/peroxymonosulfate process: An often overlooked effect of chloride.

In recent years, a significant effort has been devoted into investigating the effects of chloride on the degradation kinetics of aromatic pollutants. The impact of chloride on the decomposition of short-chain carboxylic acid intermediates from aromatics degradation has often been overlooked. In this study the roles of chloride in the oxidation of maleic acid (MA) in the Fe(II)/peroxymonosulfate (PMS) process was investigated.

Effects of chloride on PMS-based pollutant degradation: A substantial discrepancy between dyes and their common decomposition intermediate (phthalic acid).

A considerable effort has been devoted to elucidating the roles of chloride in oxidative degradation and chlorination of dyes. However, few investigations are available on kinetic analysis and transformation pathways of secondary degradation byproducts of dyes in saline wastewater treatment. Here the impact of chlorine on the degradation rate of phthalic acid, a typical dye degradation intermediate, by the Co/peroxymonosulfate (PMS) process was examined.