The Association Between Shift Work, Sleep Quality, and Health-Related Quality of Life Among Workers in the Logistics Industry.

The booming online shopping industry has accelerated the growth of logistic services, often subjecting workers to irregular schedules. This study aims to examine the association between night-shift work and health-related quality of life among logistics workers, with a special focus on the mediating role of sleep characteristics. A survey was conducted among logistics workers across China, who filled out an online questionnaire.

Integrated immunogenomic analyses of single-cell and bulk profiling construct a T cell-related signature for predicting prognosis and treatment response in osteosarcoma.

Purposes: T cells play a crucial role as regulators of anti-tumor activity within the tumor microenvironment (TME) and are closely associated with the progression of osteosarcoma (OS). Nevertheless, the specific role of T cell-related genes (TCRGs) in the pathogenesis of OS remains unclear.

Methods: First, we processed single-cell RNA sequencing (scRNA-seq) data of OS from the public databases and performed cell annotation.

Integrated analysis of single-cell RNA-seq, bulk RNA-seq, Mendelian randomization, and eQTL reveals T cell-related nomogram model and subtype classification in rheumatoid arthritis.

Objective: Rheumatoid arthritis (RA) is a systemic disease that attacks the joints and causes a heavy economic burden on humans worldwide. T cells regulate RA progression and are considered crucial targets for therapy. Therefore, we aimed to integrate multiple datasets to explore the mechanisms of RA.

Mycoplasma glycine cleavage system key subunit GcvH is an apoptosis inhibitor targeting host endoplasmic reticulum.

Mycoplasmas are minimal but notorious bacteria that infect humans and animals. These genome-reduced organisms have evolved strategies to overcome host apoptotic defense and establish persistent infection. Here, using Mycoplasma bovis as a model, we demonstrate that mycoplasma glycine cleavage system (GCS) H protein (GcvH) targets the endoplasmic reticulum (ER) to hijack host apoptosis facilitating bacterial infection.

A candidate competitive ELISA based on monoclonal antibody 3A8 for diagnosis of contagious bovine pleuropneumonia.

For the development of a competitive ELISA (cELISA) to detect serum antibodies against the Mycoplasma mycoides subsp. Mycoides (Mmm) (strain PG1), the causative agent of contagious bovine pleuropneumonia (CBPP), all the proteins of this pathogen were analyzed. Then, a specific extracellular region of a transmembrane protein with the potential for diagnosis was identified.

Postoperative intermittent pneumatic compression for preventing venous thromboembolism in Chinese lung cancer patients: a randomized clinical trial.

Background: Postoperative lung cancer patients belong to the high-risk group for venous thromboembolism (VTE). The standardized preventive measures for perioperative VTE in lung cancer are not perfect, especially for the prevention and treatment of catheter-related thrombosis (CRT) caused by carried central venous catheters (CVCs) in lung cancer surgery.

Patients And Methods: This study included 460 patients with lung cancer undergoing video-assisted thoracic surgery (VATS) in our center from July 2020 to June 2021.

Immunogenicity and efficacy of serogroup A and D bacterins against in mice.

Introduction: is a widespread respiratory pathogen in pigs, causing swine pneumonia and atrophic rhinitis, and the capsular serogroups A and D are the main epidemic serogroups in infected animals. This study investigated the protective effects of serogroup A and D bacterins against current circulating strains, to better understand the immunity generated by bacterins.

Method: 13 serogroup A (seven A: L3 and six A: L6 strains) and 13 serogroup D (all D: L6 strains) strains were isolated, and used as inactivated whole cell antigen to prepare bacterins.

Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Background: Immunotherapy has become increasingly important in the perioperative period of non-small-cell lung cancer (NSCLC). In this study, we intended to develop a mutation-based model to predict the therapeutic effificacy of immune checkpoint inhibitors (ICIs) in patients with NSCLC.

Methods: Random Forest (RF) classifiers were generated to identify tumor gene mutated features associated with immunotherapy outcomes.

Analysis on Damage and Mechanical Properties of Ballastless Track in a Tunnel after a Fire.

In order to explore the damage and mechanical properties of ballastless track after a fire, the uniaxial compressive strength, shear strength, peak strain, and elastic modulus changes due to temperature were obtained through uniaxial compressive and shear tests of concrete after exposure to high temperatures. The test results showed that with increases in temperature, the uniaxial compressive strength, shear strength, and elastic modulus of concrete all presented a decreasing trend, while the peak strain had an increasing trend. Then, based on the classical damage theory model and the strength probability distribution function of concrete micro-units, the high-temperature damage constitutive equation for concrete was established, and the compressive stress-strain curve of concrete after exposure to high temperature was reproduced.

Sintilimab combined with chidamide in the treatment of extranodal nature killer/T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis: Two case reports and literature review.

Rationale: Extranodal nature killer/T-cell lymphoma (ENKTL) failing in asparaginase-containing treatments is fatal, it has a higher mortality rate when accompanied by secondary hemophagocytic lymphohistiocytosis (HLH). The study reported 2 ENKTL-related HLH patients.

Patient Concerns: Patient 1 visited for nasal congestion and runny nose for 6 months then got a fever and serious myelosuppression after P-GEP (pegaspargase, gemcitabine, etoposide, and methylprednisolone) chemotherapy.

Retracted: Britannin mediates apoptosis and glycolysis of T-cell lymphoblastic lymphoma cells by AMPK-dependent autophagy.

The above article, published online on 19 September 2022 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/abs/10.

Influence of temperature gradient of slab track on the dynamic responses of the train-CRTS III slab track on subgrade nonlinear coupled system.

Temperature is an important load for ballastless track. However, there is little research on the system dynamic responses when a train travels on a ballastless track under the temperature gradient of ballastless track. Considering the moving train, temperature gradient of slab track, gravity of slab track, and the contact nonlinearity between interfaces of slab track, a dynamic model for a high-speed train runs along the CRTS III slab track on subgrade is developed by a nonlinear coupled way in ANSYS.

Mycoplasma hyopneumoniae membrane protein Mhp271 interacts with host UPR protein GRP78 to facilitate infection.

The unfolded protein response (UPR) plays a crucial role in Mycoplasma hyopneumoniae (M. hyopneumoniae) pathogenesis. We previously demonstrated that M.

Expression of N-methyladenosine (mA) regulators correlates with immune microenvironment characteristics and predicts prognosis in diffuse large cell lymphoma (DLBCL).

This study conducted a comprehensive analysis of the clinical significance of N-methyladenosine (mA) regulators and their relationship with immune microenvironment characteristics in diffuse large cell lymphoma (DLBCL). Consensus clustering was performed to molecularly discriminate DLBCL subtypesbased on mA regulators' expression. Using the Cox and Lasso regression algorithm, survival-associated mA regulators were identified, and a mA-based prognostic signature was established.

Sequential P-GEMOX and radiotherapy for early-stage extranodal natural killer/T-cell lymphoma: A multicenter study.

Extranodal natural killer/T-cell lymphoma, nasal-type (ENKTL) is a distinct subtype of non-Hodgkin lymphoma and most of the patients presented localized disease. Combined modality therapy (CMT), namely chemotherapy combined with radiotherapy, has been recommended for patients with early-stage ENKTL. However, the optimal CMT has not been fully clarified.

Influence of Vehicle Number on the Dynamic Characteristics of High-Speed Train-CRTS III Slab Track-Subgrade Coupled System.

In this paper, a high-speed train-CRTS III slab track-subgrade coupled dynamic model is established. With the model, the influence of vehicle number on the dynamic characteristics of a train-CRTS III slab track-subgrade coupled system with smooth and random track irregularity conditions for conventional and vibration-reduction CRTS III slab tracks are theoretically studied and analyzed. Some conclusions are drawn from the results: (1) the largest dynamic responses of the coupled system for all items and cases are no longer changed when the vehicle number exceeds three, and three vehicles are adequate to guarantee the simulation precision to investigate the dynamic responses of the coupled system.

Isolation and Characterization of Fengycins Produced by JFL21 and Its Broad-Spectrum Antimicrobial Potential Against Multidrug-Resistant Foodborne Pathogens.

The continuing emergence and development of pathogenic microorganisms that are resistant to antibiotics constitute an increasing global concern, and the effort in new antimicrobials discovery will remain relevant until a lasting solution is found. A new bacterial strain, designated JFL21, was isolated from seafood and identified as . The antimicrobial substance produced by JFL21 showed low toxicity to most probiotics but exhibited strong antimicrobial activities against multidrug-resistant foodborne pathogens.

Recombinant bluetongue virus with hemagglutinin epitopes in VP2 has potential as a labeled vaccine.

Bluetongue (BT) is an arbovirus-borne disease of ruminants caused by bluetongue virus (BTV) that has the potential to have a serious economic impact. Currently available commercial vaccines include attenuated vaccines and inactivated vaccines, both of which have achieved great success in the prevention and control of BTV. However, these vaccines cannot distinguish between infected animals and immunized animals.

Development and optimization of a DNA-based reverse genetics systems for epizootic hemorrhagic disease virus.

Epizootic hemorrhagic disease virus (EHDV) is a member of the genus Orbivirus, family Reoviridae, and has a genome consisting of 10 linear double-stranded (ds) RNA segments. The current reverse genetics system (RGS) for engineering the EHDV genome relies on the use of in vitro-synthesized capped viral RNA transcripts. To obtain more-efficient and simpler RGSs for EHDV, we developed an entirely DNA (plasmid or PCR amplicon)-based RGS for viral rescue.

PCR-based reverse genetics strategy for bluetongue virus recovery.

Background: Bluetongue virus (BTV), an emerging insect vector mediated pathogen affecting both wild ruminants and livestock, has a genome consisting of 10 linear double-stranded RNA genome segments. BTV has a severe economic impact on agriculture in many parts of the world. Current reverse genetics (RG) strategy to rescue BTV mainly rely on in vitro synthesis of RNA transcripts from cloned complimentary DNA (cDNA) corresponding to viral genome segments with the aid of helper plasmids.

HONN-Based Adaptive ILC for Pure-Feedback Nonaffine Discrete-Time Systems With Unknown Control Directions.

Nearly all adaptive control techniques require that the control directions of dynamical systems are known in advance. In this paper, for a class of pure-feedback nonaffine discrete-time systems with unknown control directions (UCDs), a high-order neural network (HONN)-based adaptive iterative learning control (ILC) approach is presented to address a repetitive tracking control issue. The implicit function theorem is adopted to cope with the difficulty resulting from the nonaffine structure of control input.

Impaired cellular energy metabolism contributes to bluetongue-virus-induced autophagy.

Bluetongue virus (BTV) has been found to trigger autophagy to favor its replication, but the underlying mechanisms have not been clarified. Here, we show that cellular energy metabolism is involved in BTV-induced autophagy. Cellular ATP synthesis was impaired by BTV1 infection, causing metabolic stress, which was responsible for activation of autophagy, since the conversion of LC3 and aggregation of GFP-LC3 (autophagy markers) were suppressed when infection-caused energy depletion was reversed via MP (metabolic substrate) treatment.