The Complexity in Complete Graphic Characterizations of Multiagent Controllability.

Establishing the graph-based criterion for the selection of any location and any number of leaders is the main difficulty in the complete graphic characterization of multiagent controllability. This greatly increases the complexity of the study, compared with the results derived for only one or several classes of leaders. Through a detailed analysis of graphs of six nodes, this article presents a systematic design and identification process for the complete graphic characterization by taking advantage of controllability destructive nodes.

Output Feedback Control and Stabilization for Multiplicative Noise Systems With Intermittent Observations.

This paper mainly focuses on the optimal output feedback control and stabilization problems for discrete-time multiplicative noise system with intermittent observations. The main contributions of this paper can be concluded as follows. First, different from the previous literatures, this paper overcomes the barrier of the celebrated separation principle for stochastic control problems of multiplicative noise systems.

Output Feedback Control and Stabilization for Networked Control Systems With Packet Losses.

This paper mainly considers the optimal measurement feedback control and stabilization for networked control systems (NCSs) with packet losses. The problems are involved with fundamental difficulties of separation principle and optimal estimation (conditional expectation) for multiplicative noise stochastic systems. First, the optimal estimator (conditional expectation) for NCSs with packet losses is derived and the optimal measurement feedback controller is obtained by using the maximum principle.

Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with norcantharidin and benzimidazole derivatives.

Two novel complexes [Cu(L)2(Ac)2]·3H2O (1) (L=N-2-methyl benzimidazole demethylcantharate imide, C16H15N3O3, Ac=acetate, C2H3O2) and [Cu(bimz)2(DCA)] (2) (bimz=benzimidazole, C7H6N2; DCA=demethylcantharate, C8H8O5) were synthesized and characterized by elemental analysis, infrared spectra and X-ray diffraction techniques. Cu(II) ion was four-coordinated in complex 1, Cu(II) ion was five-coordinated in complex 2. A large amount of intermolecular hydrogen-bonding and π-π stacking interactions were observed in these complex structures.

Expression of E-cadherin and nm23 is associated with the clinicopathological factors of human non-small cell lung cancer in China.

E-cadherin, a calcium-dependent cell-cell adhesion molecule, functions as maintenance of epithelial integrity. nm23, encoded by non-metastatic 23 gene, plays a key role in differentiation of many kinds of epithelium. Loss or dysfunction of E-cadherin and nm23 was frequently identified in many types of human cancers and is considered to correlate with invasive/metastatic phenotype.

Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer.

Purpose: Reduced expression of the transforming growth factor beta receptor type II (TGF beta RII), a key inhibitor of epithelial cell growth and tumor suppressor gene, was reported frequently in many types of tumors including non-small cell lung cancer (NSCLC). This study explored the significance of the TGF beta RII gene in NSCLC carcinogenesis.

Experimental Design: With 43 independent pairs of tumor and paracarcinoma tissue samples from patients with primary NSCLC, we carried out PCR-denaturing gradient gel electrophoresis screening for DNA variants over the coding sequence of the TGF beta RII gene, immunohistochemical assay of TGF beta RII expression, methylation-specific PCR analysis, and semiquantitative reverse transcription-PCR.

Mutational analysis of the transforming growth factor beta receptor type I gene in primary non-small cell lung cancer.

Transforming growth factor-beta receptor-dependent signals are critical for cell growth and differentiation and are often disrupted during tumorigenesis. The entire coding region of TGFbetaRI and flanking intron sequences from 53 primary non-small cell lung cancer (NSCLC) tissues were examined for alterations using SSCP and direct sequencing. No somatic point mutations other than two silent mutations and a polymorphism were found in the TGFbetaRI gene.

Defected expression of E-cadherin in non-small cell lung cancer.

Reduced expression of E-cadherin, a cell-cell adhesion molecule, was frequently observed in several types of human carcinomas, and the protein plays a role as an invasion suppressor in vitro. In an attempt to evaluate the significance of E-cadherin gene in non-small cell lung cancer (NSCLC), we undertook the immunohistochemical and molecule structural analyses of E-cadherin gene in 40 resection specimens of NSCLC and the corresponding paracarcinoma controls. E-cadherin expression was explored by immunohistochemistry with a monoclonal antibody, and the E-cadherin gene was studied by polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP).