Publications by authors named "Qingyuan Li"
Article Synopsis
Article Synopsis
- We are regularly exposed to various environmental pollutants, but advancements in stem cell toxicology are providing better research opportunities in understanding their effects.
- By using stem cell technology, we can improve the prediction of how toxic these pollutants are compared to traditional methods, although there's still room for improvement in detection processes.
- Our study developed a detection model using TBXT-EGFP iPS cells to screen 38 common environmental pollutants, revealing that some, like TBBPA-BDBPE and TBBPA-BHEE, could disrupt essential genes involved in early human embryo development, potentially leading to developmental issues.
Microorganisms are vital for the health of marine invertebrates, and their assembly is driven by both deterministic and stochastic factors that regulate residents (innate to the host) and transients (from ambient water). However, the role of water microbiota and the significance of deterministic and stochastic processes in aquatic hosts facing mortality threats are largely unknown. This study examines the shifts in water microbiota during an oyster mortality event using amplicon sequencing and compared with those of resident oysters to disentangle the balance of the deterministic and stochastic factors involved.
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- The study aimed to explore the connection between vitamin D levels (25(OH)D) and obstructive sleep apnoea (OSA), while considering the role of body mass index (BMI) as a potential confounding factor.
- Using data from the 2007-08 National Health and Nutrition Examination Survey (NHANES), researchers analyzed responses from 4,901 individuals aged 16 and older.
- Results initially indicated a negative association between low vitamin D levels and OSA, but this significance disappeared when adjusting for BMI, suggesting that obesity may play a key role in this relationship rather than vitamin D directly influencing OSA.
Article Synopsis
- Previous studies suggest a possible link between obstructive sleep apnea (OSA) and a higher risk of lung cancer, but comprehensive research on their correlation is limited.* -
- A meta-analysis, involving over 6.5 million individuals, found that patients with OSA have a significant increase in lung cancer risk (HR 1.28), but a Mendelian randomization study did not support a causal relationship.* -
- Overall, while OSA may be associated with a greater risk of lung cancer, the current evidence does not establish that OSA directly causes lung cancer, indicating the need for more research.*
Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway.
Int Immunopharmacol
August 2024
Article Synopsis
Article Synopsis
- Impaired function of succinate dehydrogenase complex subunit C (SDHC) is linked to poor prognosis and increased metastasis in colorectal cancer (CRC).
- Studies show downregulation of SDHC enhances CRC cell movement and tumor spread, while its silencing disrupts fatty acid metabolism and activates the PI3K/AKT signaling pathway.
- Targeting fatty acid synthesis can reverse the effects of SDHC silencing, suggesting potential therapeutic strategies to manage CRC progression.