Exploring mRNA translation strategies for hypoxia adaptation across distantly related metazoans.

Adaptation to variations in oxygen concentration is a conserved mechanism in all metazoans. Extensive studies have been focused on the roles of hypoxia-inducible factors (HIFs) in response to hypoxia. However, HIF1α is not conserved in all animals, and HIF2α and HIF3α are only observed in vertebrates.

Clinical value of ARG1 in acute myocardial infarction patients: Bioinformatics-based approach.

Background: In this study, we aimed to explore key genes as biomarker for diagnosis AMI through using Bioinformatics tools.

Methods: GSE4648 and GSE60993 were downloaded from Gene Expression Omnibus (GEO). DEGs in GSE4648 and GSE60993 were selected to run GO enrichment, KEGG pathway, and PPI network.

Effects of Taishan Robinia pseudoacacia Polysaccharides on immune function in chickens.

To determine the immune function of Taishan Robinia pseudoacacia Polysaccharide (TRPPS) on chickens, 240 chickens were selected as experimental animals and treated with various doses of TRPPS by hypodermic injection before immunized NDV inactivated vaccine. The results indicated that any dose of TRPPS could significantly promote the development of the immune organs, increase the quantity of leukocyte and the ratio of lymphocyte, and improve the antibody titers against Newcastle disease. Meanwhile, it also increased the magnitude of SIgA in duodenum.

Pathogenicity of Bordetella avium under immunosuppression induced by Reticuloendotheliosis virus in specific-pathogen-free chickens.

Multiple infections of Bordetella avium (B. avium) with virus, especially immunosuppressive virus, have become more and more severe in chickens in China. The increasing morbidity and mortality of its complications have amplified concerns about the impact of B.

Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines.

Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines.