Semiconductive Coordination Polymer with Multi-Channel Charge Transfer for High-Performance Direct X-ray Detection.

Coordination polymers (CPs) are promising for direct X-ray detection and imaging owing to higher designability and outstanding stability, however, it remains a challenge to achieve highly X-ray detection performance, particularly both high sensitivity and low detection limit at the same operating voltage. Herein, we construct a new conjugated CP {[Co(BPTTz)(DIPA)] ⋅ DMA} (1, BPTTz=2,5-bis(pyridine-4-yl)thiazolo[5,4-d]thiazole, HDIPA=2,5-diiodoterephthalic acid, DMA=N, N'-dimethylacetamide), with multi-channel charge transfer by regulating the linker mediated electronic-state, which reduces carrier losses resulting from recombination or quenching, enhances the efficiency of charge separation and transfer, thus further optimizes X-ray detection performance. The semiconductor prepared based on this strategy achieves record values including the highest mobility-lifetime product (μτ, 8.

Novel biomarkers and drug correlations of non-canonical WNT signaling in prostate and breast cancer.

Prostate cancer (PCa) and breast cancer (BC) present formidable challenges in global cancer-related mortality, necessitating effective management strategies. The present study explores non-canonical Wnt signaling in PCa and BC, aiming to identify biomarkers and assess their clinical and therapeutic implications. Co-expression analyses reveal distinct gene patterns, with five overlapping genes (SULF1, ALG3, IL16, PLXNA2 and RASGFR2) exhibiting divergent expression in both cancers.

A novel electrochemiluminescent sensor based on AgMOF@N-CD composites for sensitive detection of trilobatin.

In this study, a novel electrochemiluminescent (ECL) sensor for highly sensitive detection of trilobatin (Tri) was developed based on silver metal-organic frameworks (AgMOFs) and nitrogen-doped carbon quantum dots (N-CDs). N-CDs exhibited high ECL intensity but poor ECL stability, while AgMOFs had a large specific surface area, high porosity, and good adsorption properties. Compositing both of them not only improved the ECL stability of N-CDs, but also enhanced the ECL strength of materials, so AgMOF@N-CD composites were used as the luminophore of the sensor.

Electron Reservoir Effect of Adjacent Fe Nanoclusters Boosts Atomic Fe Active Sites on Porous Carbon for the Both Electrocatalytic Oxygen Reduction and CO Reduction Reaction.

Electrochemical oxygen reduction reaction (ORR) and carbon dioxide reduction reaction (CORR) are greatly significant in renewable energy-related devices and carbon-neutral closed cycle, while the development of robust and highly efficient electrocatalysts has remained challenges. Herein, a hybrid electrocatalyst, featuring axial N-coordinated Fe single atom sites on hierarchically N, P-codoped porous carbon support and Fe nanoclusters as electron reservoir (Fe/Fe-NPC), is fabricated via in situ thermal transformation of the precursor of a supramolecular polymer initiated by intermolecular hydrogen bonds co-assembly. The Fe/Fe-NPC catalyst manifests superior oxygen reduction activity with a half-wave potential of 0.

Aberrant patterns of spontaneous brain activity in schizophrenia: A resting-state fMRI study and classification analysis.

Background: Schizophrenia is a prevalent mental disorder, leading to severe disability. Currently, the absence of objective biomarkers hinders effective diagnosis. This study was conducted to explore the aberrant spontaneous brain activity and investigate the potential of abnormal brain indices as diagnostic biomarkers employing machine learning methods.

Association of anhedonia with brain-derived neurotrophic factor and interleukin-10 in major depressive disorder.

Background: Anhedonia, a core symptom of major depressive disorder (MDD), manifests in two forms: anticipatory and consummatory, reflecting a diminished capacity to anticipate or enjoy pleasurable activities. Prior studies suggest that brain-derived neurotrophic factor (BDNF) and interleukin-10 (IL-10) may play key roles in the emergence of anhedonia in MDD. The specific relationships between these biomarkers and the two forms of anhedonia remain unclear.

Association between stressful life events and sleep quality in Chinese university students: Mediating and moderating roles of emotion regulation.

This study investigated whether emotion regulation mediates or modulates the relationship of SLEs with sleep quality and potential sex differences. A total of 1447 Chinese university students completed the Adolescent Self-Rating Life Events Checklist, the Pittsburgh Sleep Quality Index, and the Emotion Regulation Questionnaire. The results indicated that both cognitive reappraisal and expressive suppression significantly mediated and moderated the negative association between SLEs and sleep quality.

Derailment in adolescence: Factor analytic structure and correlates.

Derailment is the sense of being "off-course" in life. But what could this mean for adolescents, who are often establishing identity and self-direction for the first time? We examined the structure and correlates of the Derailment Scale and its short form, the Derailment Scale-6 (DS-6), among middle-to-late adolescents (N = 452). Both scales exhibited unidimensionality, but the DS-6 demonstrated superior fit and correlated with cross-sectional distress markers (e.

An electrochemiluminescence sensor based on Ag NPs amplifying PDDA-modified TbPO:Ce NWs signal for sensitive detection of lincomycin.

The residue of lincomycin in water will not only aggravate the drug resistance of bacteria but also cause damage to the human body through biological accumulation. In this work, an electrochemiluminescence (ECL) aptasensor for the detection of lincomycin was constructed based on polydimethyldiallylammonium chloride (PDDA) functionalized Ce-doped TbPO nanowires (PDDA-TbPO:Ce NWs) and silver nanoparticles (Ag NPs). TbPO:Ce NWs were used as the luminophore, and PDDA was used to functionalize the luminophore to make the surface of the luminophore positively charged.

Insights into Aerosol Emission Control in the Postcombustion CO Capture Process: From Cluster Formation to Aerosol Growth.

Aerosols produced in the amine carbon capture process can lead to secondary environmental pollution. This study employs molecular dynamics (MD) simulations to investigate cluster formation, amine behavior, and aerosol growth of amines, essential for reducing amine aerosol emissions. Results showed that the cluster evolution process can be divided into cluster formation and growth in terms of molecular content, and the nucleation rate for the present systems was estimated in the order of 10 cm s.

Purpose and goal pursuit as a self-sustaining system: Evidence of daily within-person reciprocity among adolescents in self-driven learning.

Objective: Despite long-standing assumptions that a sense of purpose in life and goal pursuit are mutually supportive, empirical evidence of their reciprocity remains deficient. In the context of a unique out-of-school time program that empowers youth to pursue passions through self-driven learning, we examined whether purpose and one aspect of goal pursuit-perceptions of goal progress-work together to sustain themselves and each other over time.

Method: Adolescents (N = 321) completed daily surveys throughout program enrollment (M = 69.

Associations between physical activity and proactive control and the modulating role of working memory.

Accumulating evidence indicates positive associations between physical activity (PA) and cognitive control. Proactive control, the ability to maintain goal-relevant information in preparation of upcoming task demands, is a critical component of cognitive control. However, little research has examined the association between PA and proactive control.

A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.

Trilobatin is a flavonoid that has wide application prospects due to its various pharmacological effects, such as anti-inflammation and anti-oxidation. In this work, a novel electrochemical sensor based on gold nanobipyramids (AuNBs) and L-cysteine (L-cys) was constructed for the sensitive and selective determination of trilobatin. The AuNBs, which were prepared by a seed-mediated growth method, had large specific surface areas and excellent electrical conductivity.

Boundary optimization of inclined coal seam open-pit mine based on the ISSA-LSSVR coal price prediction method.

As an important link in the complex system engineering project of open pit mining, the quality of the boundary determines the performance of the project to a large extent. However, changes in economic indicators may raise doubts about the optimality of mining boundaries. In this article, a coal price time series forecasting model that considers some amount of redundancy is proposed, which combines an improved sparrow search algorithm (ISSA) and a least squares support vector regression machine regression (LSSVR) algorithm.

Interacting with supportive adults predicts greater same-day psychosocial functioning among adolescents in a self-driven learning program.

Introduction: Supportive adults are a critical component of effective out-of-school time (OST) youth programs, yet the short-term dynamics that underlie their role are poorly understood. Within GripTape, a US-wide self-driven learning program, we examined if interactions with program-assigned adults (i.e.

Factors associated with first-generation immigrant parents' unwillingness to vaccinate their daughters for HPV.

Purpose: Human papillomavirus (HPV) vaccination rates for children of immigrant parents are substantially lower than US peers. This study aimed (1) to assess the prevalence of immigrant parents' unwillingness to vaccinate their daughters, (2) to compare by race/ethnicity the prevalence of immigrant parents' unwillingness to vaccinate their daughters, and (3) to examine predictors of the unwillingness stratified by race/ethnicity.

Method: This study conducted a secondary analysis of data from the Health Information National Trends Survey (HINTS).

Dense is not green: How visual density influences greenness evaluation on environmentally friendly products.

Introduction: The visual design of environmentally friendly products has a strong influence on consumer decisions. The study offers a novel insight, suggesting that consumers' perceptions of environmentally friendly products may be affected by the visual density design.

Methods: Four experiments tested the effect of visual density on the perceived greenness of environmentally friendly products.

The association between social determinants of health and psychological distress during the COVID-19 pandemic: a secondary analysis among four racial/ethnic groups.

Background: Racial disparities in psychological distress associated with COVID-19 remain unclear in the U.S. This study aims to investigate the associations between social determinants of health and COVID-19-related psychological distress across different racial/ethnic groups in the US (i.

The advances of calcium oxalate calculi associated drugs and targets.

Kidney stones constitute a disease of the urinary system of high incidence that has only a few available stone dissolving drugs as treatment options. The mechanism of calcium oxalate stone formation is still largely unclear. Various aspects and theories for initiation and formation of the renal stones have been suggested, and the complex multistep formation process of the kidney stones includes supersaturation, nucleation, growth and aggregation of a crystal, and crystal retention in cells after adhesion.

Transcriptional Profiling of TGF-β Superfamily Members in Lumbar DRGs of Rats Following Sciatic Nerve Axotomy and Activin C Inhibits Neuropathic Pain.

Background: Neuroinflammation and cytokines play critical roles in neuropathic pain and axon degeneration/regeneration. Cytokines of transforming growth factor-β superfamily have implications in pain and injured nerve repair processing. However, the transcriptional profiles of the transforming growth factor-β superfamily members in dorsal root ganglia under neuropathic pain and axon degeneration/regeneration conditions remain elusive.

Mitochondrial Porin Is Involved in Development, Virulence, and Autophagy in .

Mitochondrial porin, the voltage-dependent anion-selective channel (VDAC), is the most abundant protein in the outer membrane, and is critical for the exchange of metabolites and phospholipids in yeast and mammals. However, the functions of porin in phytopathogenic fungi are not known. In this study, we characterized a yeast porin orthologue, Fgporin, in .

Genome-Wide Association Studies and Haplotype-Sharing Analysis Targeting the Egg Production Traits in Shaoxing Duck.

Age at first egg (AFE) and egg number (EN) are economically important traits related to egg production, as they directly influence the benefits of the poultry industry, but the molecular genetic research that affects those traits in laying ducks is still sparse. Our objective was to identify the genomic regions and candidate genes associated with AFE, egg production at 43 weeks (EP43w), and egg production at 66 weeks (EP66w) in a Shaoxing duck population using genome-wide association studies (GWASs) and haplotype-sharing analysis. Single-nucleotide polymorphism (SNP)-based genetic parameter estimates showed that the heritability was 0.