Mercury isotope fractionation and mercury source analysis in coal.

Understanding the sources of mercury (Hg) in coal is crucial for understanding the natural Hg cycle in the Earth's system, as coal is a natural Hg reservoir. We conducted analyses on the mass-dependent fractionation (MDF), reported as δHg, and mass-independent fractionation (MIF), reported as ΔHg, of Hg isotopes among individual Hg species and total Hg (THg) in Chinese coal samples. This data, supplemented by a review of prior research, allowed us to discern the varying trend of THg isotope fractionation with coal THg content.

Isotope-Based Characterization of Soil Elemental Mercury Emissions from Historical Mercury Mining Areas: Driving Pathways and Relative Contributions.

Photo-, microbial, and abiotic dark reduction of soil mercury (Hg) may all lead to elemental mercury (Hg(0)) emissions. Utilizing lab incubations, isotope signatures of Hg(0) emitted from mining soils were characterized to quantify the interplay and contributions of various Hg reduction pathways, which have been scarcely studied. At 15 °C, microbial reduced Hg(0) showed a negative mass-dependent fractionation (MDF) (δHg = -0.

Hepatitis B Virus-Mediated m6A Demethylation Increases Hepatocellular Carcinoma Stemness and Immune Escape.

Unlabelled: Hepatitis B viral (HBV) persistent infection plays a significant role in hepatocellular carcinoma (HCC) tumorigenesis. Many studies have revealed the pivotal roles of N6-methyladenosine (m6A) in multiple cancers, while the regulatory mechanism in stemness maintenance of HBV persistent infection-related HCC remains elusive. Here, we demonstrated that the level of m6A modification was downregulated by HBV in HBV-positive HCC, through enhanced stability of ALKBH5 mRNA.

[Research Progress in the Relationship Between Neurofilament Light Chain Protein and Cognitive Impairment in Type 2 Diabetes Mellitus].

Metabolic abnormality in type 2 diabetes mellitus(T2DM)can cause damage to the central nervous system,leading to cognitive decline.Neurofilament light chain protein(NFL),as a blood marker of neuroaxonal injuries,is significantly associated with the onset of cognitive impairment and affected by the renal function.It can participate in the development of cognitive impairment in T2DM through inflammation,blood-brain barrier breakdown,interaction between microglia and neurons,and Tau protein phosphorylation.

Unveiling the driving factors of urban land subsidence in Beijing, China.

Land subsidence, an insidious and gradual geological phenomenon, presents a latent threat to future urban development and socio-economic progress. Beijing City, renowned for its high population density, has encountered significant challenges associated with land subsidence. In this study, we leverage time-series interferometric synthetic aperture radar (time-series InSAR) method to analyze the spatio-temporal patterns of land subsidence in Beijing.

[Research Progress in the Role of Tamoxifen in Nervous System and Cognitive Function].

Neurological diseases include a variety of neurodegenerative diseases and other brain damage diseases.The treatment schemes for neurological diseases are still in research.The existing clinical and basic studies have confirmed that traditional estrogen therapy has certain protective effect on the nervous system,while it increases the risk of breast or endometrial cancer.

A High-Salt Diet Exacerbates Liver Fibrosis through -Dependent Macrophage Activation.

People consume more salt than the recommended levels due to poor dietary practices. The effects of long-term consumption of high-salt diets (HSD) on liver fibrosis are unclear. This study aimed to explore the impact of HSD on liver fibrosis.

Effects of water-coal interactions on coal mine water quality in China: a lixiviation experiment and actual water quality investigation.

Water-coal interactions are dominant factors that affect water quality in coal mines. Using lixiviation, the effects of water-coal interactions on pH, salinity, and hazardous elemental enrichment in coal mine water and associated trends were simulated and analyzed. The salinity and hazardous element contents were low in the alkaline solution filtrate.

Expression, Prognostic Value, and Functional Mechanism of Polarity-Related Genes in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognoses around the world. Within-cell polarity is crucial to cell development and function maintenance, and some studies have found that it is closely related to cancer initiation, metastasis, and prognosis. The aim of our research was to find polarity-related biomarkers which improve the treatment and prognosis of HCC.

Dissolution of harmful trace elements from coal and the environmental risk to mine water utilization.

Under the pressure of water shortages, coal mine water has been allocated as a national water resource in China. However, the existence of harmful trace elements (HTEs) in coal mine water causes environmental risks and health concerns over its reuse. Through a lixiviation experiment, the dominant factors affecting the dissolution of HTEs in coal were simulated and analyzed, and the environmental risks of HTEs in coal mine water in China were evaluated for the first time.

Education plays a crucial role in the pathway from poverty to smoking: a Mendelian randomization study.

Background And Aims: Disproportionately high rates of smoking have been found in low-income communities, but the causal direction and role of education in this relationship remains less well understood. Here, we used bidirectional Mendelian randomization (MR) to measure the causal relationships between smoking, income and education.

Design: Two-sample univariable and multivariable MR analyses were conducted to evaluate the total and direct effect of income and education on tobacco smoking.

Construction and validation of a prognostic risk model for breast cancer based on protein expression.

Breast cancer (BRCA) is the primary cause of mortality among females globally. The combination of advanced genomic analysis with proteomics characterization to construct a protein prognostic model will help to screen effective biomarkers and find new therapeutic directions. This study obtained proteomics data from The Cancer Proteome Atlas (TCPA) dataset and clinical data from The Cancer Genome Atlas (TCGA) dataset.

Uranium in Chinese coals: Concentration, spatial distribution, and modes of occurrence.

Uranium in coals is an environmental radionuclide with resource utilization value. To comprehensively understand the prevalence of uranium in Chinese coals, the concentration, spatial distribution, and modes of occurrence were analyzed based on the data acquired from 1326 coal samples. Chinese coals are relatively rich in uranium, with the arithmetic and weighted average concentrations of 3.

Translational and post-translational control of human naïve versus primed pluripotency.

Deciphering the regulatory network for human naive and primed pluripotency is of fundamental theoretical and applicable significance. Here, by combining quantitative proteomics, phosphoproteomics, and acetylproteomics analyses, we revealed RNA processing and translation as the most differentially regulated processes between naive and primed human embryonic stem cells (hESCs). Although glycolytic primed hESCs rely predominantly on the eukaryotic initiation factor 4E (eIF4E)-mediated cap-dependent pathway for protein translation, naive hESCs with reduced mammalian target of rapamycin complex (mTORC1) activity are more tolerant to eIF4E inhibition, and their bivalent metabolism allows for translating selective mRNAs via both eIF4E-dependent and eIF4E-independent/eIF4A2-dependent pathways to form a more compact naive proteome.

Investigation and source analysis of bacterial contamination in groundwater in Liuzhou City, China.

Groundwater is an important water source to consider when ensuring the safety of urban water supply. Groundwater contaminated by bacteria poses a potential health risk to the drinking water supply. This study focuses on the water supply of Liuzhou City, a famous industrial city in China.

Interleukin-33 as an early predictor of cetuximab treatment efficacy in patients with colorectal cancer.

Background: Cetuximab is used for colorectal cancer (CRC) treatment. However, the early biomarker of treatment efficacy of cetuximab has not been identified.

Methods: After 1 year of cetuximab treatment, patients were divided into an effective group and an ineffective group.

The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.

Aims: To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.

Methods: This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected.

Environmental geochemical maps of harmful trace elements in Chinese coalfields.

Coal resource utilization and environmental protection is a critical global issue. This study aims to address the need for geochemical maps of harmful trace elements (HTEs) in Chinese coalfields and to extract scientific information from these maps. Based on data extracted from the Trace Elements in Coal of China database, geochemical maps of As, Cd, Cr, F, Hg, Ni, Pb, and Se in Chinese coalfields were generated, for the first time, using the ArcGIS platform.

Concentration and speciation of mercury in atmospheric particulates in the Wuda coal fire area, Inner Mongolia, China.

Coal-seam fire is a source of atmospheric mercury that is difficult to control. The Wuda Coalfield in Inner Mongolia, China, is one of the most severe coal fire disaster areas worldwide and has been burning for more than 50 years. To investigate atmospheric mercury pollution from the Wuda coal fire, gaseous elemental mercury (GEM) concentrations and atmospheric particulate mercury (PHg) speciation were measured using a RA-915+ mercury analyzer and the temperature-programmed desorption method.

Role of H, HF, SO and kaolin in fixing Hg of coal fire sponge.

Coal fire sponges (CFS) are common in coal-fire areas. Due to the enrichment of Hg in CFS, large amounts of Hg are released by CFS into the atmosphere via natural weathering or solar radiation. Therefore, CFS should be of concern in Hg pollution management and control globally.

Spatial distribution of harmful trace elements in Chinese coalfields: An application of WebGIS technology.

Harmful trace elements in coal have caused serious damage to the environment and human health. Understanding their spatial distribution is helpful for environmental health assessment and for their effective control and utilization. To further explore the geospatial distribution of harmful trace elements found in Chinese coals, this work constructed the Trace Elements in Chinese Coals Database Management System (TECC), and analysed the spatial distribution of harmful trace elements by applying spatial data algorithms and visual technology of WebGIS.

Study on Mercury Species in Coal and Pyrolysis-Based Mercury Removal before Utilization.

Coal-fired mercury (Hg) pollution control is an important global environmental context. Eight coal samples from different coal fields in China were used to investigate Hg species and the Hg removal effects under different pyrolysis conditions in the presence of nitrogen. These conditions included temperature, particle size, and residence time.

Mercury sources in a subterranean spontaneous combustion area.

Mercury is a toxic, persistent, and mobile contaminant. Coal spontaneous combustion are widely distributed in the world and releases a great deal of Hg. Identifying the burning coal seam is crucial for quickly extinguishing a coalfield fire.

Multiple novel hepatocellular carcinoma signature genes are commonly controlled by the master pluripotency factor OCT4.

Background: Worldwide, hepatocellular carcinoma (HCC) is a common solid tumor with a poor prognosis. HCC is often due to hepatitis B virus (HBV) infection. As yet, efficacious HCC treatment regimens for late-stage HCC patients are lacking.

Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare.

Methods: The transcriptomic profiling of 12 HCC tissues and paired adjacent normal tissues was determined using high-throughput RNA sequencing.