The relationship between obesity associated weight-adjusted waist index and the prevalence of hypertension in US adults aged ≥60 years: a brief report.

Objectives: The main objective was to examine the relationship between weight-adjusted waist index (WWI) and the prevalence of hypertension among individuals aged ≥60 years who participated in the NHANES between 2011 and 2018 years.

Methods: The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. In this population-based study, we focused on participants who were over 60 years old.

Left Bundle Branch Area Pacing in a Giant Atrium With Atrial Standstill: A Case Report and Literature Review.

Atrial standstill (AS) is a rare condition defined by the lack of atrial electrical and mechanical activities. It is usually clinically manifested as symptomatic bradycardia, which requires permanent pacemaker (PPM) implantation. Traditional right ventricular apical pacing causes electrical and mechanical dyssynchrony resulting in left ventricular dysfunction, heart failure, and arrhythmias.

PDA-coated CPT@MIL-53(Fe)-based theranostic nanoplatform for pH-responsive and MRI-guided chemotherapy.

Theranostic nanoplatforms for multimodal diagnosis and treatment of tumors are a current research hotspot in the field of nanomedicine. MOF-based theranostic nanoplatforms integrating drug delivery with magnetic resonance imaging (MRI) have attracted broad attention in cancer diagnosis and therapy. However, due to the poor chemical and colloidal stability of MOFs, as well as their poor biocompatibility, MOF-based theranostic nanoplatforms still face critical challenges in cancer treatment applications.

Liquid exfoliated biocompatible WS@BSA nanosheets with enhanced theranostic capacity.

Ultrathin transition metal dichalcogenides (TMDs) seem to have a promising future in the field of theranostic agents due to their excellent near-infrared light absorption capacity and large specific surface area. Plenty of previous studies focused on the therapeutic effects of the materials, but were less concerned with the detailed studies of biocompatibility for clinical transformation. In this work, ultrathin WS2 nanosheets coated with bovine serum protein (BSA) (WS2@BSA NSs) were selected as experimental subjects with favorable biocompatibility to explore their potential as a theranostic agent.

A FRET-based fluorescent probe for hydrogen peroxide based on the use of carbon quantum dots conjugated to gold nanoclusters.

In the Fenton reaction, ferrous ion acts as a catalyst and reacts with hydrogen peroxide (HO) to produce hydroxy radicals (·OH) and hydroperoxy radicals (·OOH). Both have much stronger oxidization ability than HO. A fluorescent probe for HO is described here that was obtained by covalent conjugation of carbon quantum dots to gold nanoclusters (AuNCs).

Sonochemical assisted synthesis of dual functional BSA nanoparticle for the removal of excessive bilirubin and strong anti-tumor effects.

In this study, we prepared a dual functional albumin-based nanoparticle (gal-BSA-NPs) by sonochemical method which allowed an efficient encapsulation for Bilirubin (BR) through its adsorption capacity and hydrophobic interaction. Our study provided a possibility that the blank gal-BSA-NPs can replace BSA with better ability for the adsorption of excessive BR. Additionally, we unearthed the potential anti-tumor activity of BR on HepG2 cells and developed GSH-responsive BR-loaded gal-BSA-NPs for the treatment of liver cancer.

Ultrasmall Au-Ag Alloy Nanoparticles: Protein-Directed Synthesis, Biocompatibility, and X-ray Computed Tomography Imaging.

The ultrasmall sizes of nanoparticles have attracted significant attention for potential applications in the fields of catalysis and nanomedicine. Herein, we reported on the green preparation and X-ray computed tomography (CT) imaging of ultrasmall bimetallic bovine serum albumin-directed gold-silver (Au-Ag@BSA) nanoparticles (2-4 nm) using BSA as a stabilizing and template-directed agent. Further, the effects of synthesis conditions were systematically explored to prepare products by adjusting the different molar ratios of Au/Ag.

ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO).

ESIPT-based fluorescence probes are emerging as an attractive tool for the detection of biologically relevant analytes owing to their unique photophysical properties. In this work, we have developed an ESIPT-based fluorescence probe (TCBT-OMe) for the detection of HClO/ClO- through the attachment of a bioorthogonal dimethylthiocarbamate linker. TCBT-OMe was shown to rapidly detect HClO/ClO- (<10 s) at biologically relevant concentrations (LoD = 0.