Hierachical Aerogel-Supported Cu-Sn-O Solid Solutions for Highly Selective CO Electroreduction and Zn-CO Batteries.

The electrochemical CO reduction reaction (CORR) into high-value carbon compounds such as CO and HCOOH is a promising strategy for the utilization and conversion of emitted CO. However, the selectivity of the CORR for HCOOH is typically less than 90% and operates within a narrow voltage range, which limits its practical application. Herein, we propose a novel heterostructural aerogel as a highly efficient electrocatalyst for CORR to HCOOH.

Three methods to optimise polymyxin B dosing using estimated AUC after first dose: validation with the data generated by Monte Carlo simulation.

To achieve the AUC-guided dosing, we proposed three methods to estimate polymyxin B AUC across 24 h at steady state (AUC) using limited concentrations after its first dose.Monte Carlo simulation based on a well-established population PK model was performed to generate the PK profiles of 1000 patients with normal or abnormal renal function. Polymyxin B AUC was estimated for each subject using three methods (two-point PK approach, three-point PK approach, and four-point PK approach) based on limited concentration data in its first dose and compared with the actual AUC at steady state calculated using the linear-trapezoidal formula.

The impact of distance education on the socialization of college students in the Covid-19 era: problems in communication and impact on mental health.

Background: The problems of students' social interaction and psychological well-being associated with online learning dependent on self-directed learning have become an important topic of research in recent years worldwide due to the COVID-19 pandemic, affecting their Social Emotional Learning. This paper aimed to compare the students' loneliness, social anxiety, social interaction, and general psychological well-being at different stages of online learning (at the beginning and the height of the pandemic), considering their criteria (presence/absence of a job and own family).

Methods: For this, the researchers conducted an electronic survey of students (n = 320) twice, in February and May 2020, using four questionnaires: UCLA loneliness scale-3, Social Anxiety Scale for E-Learning Environments, Social Interaction Scale, and Brief Adjustment Scale.

Common neural dysfunction of economic decision-making across psychiatric conditions.

Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis.

Quantifying Contributions of Different Repulsion to Film Drainage Time during the Bubble-Solid Surface Attachment and Implications for the Flotation of Fine Particles.

The flotation recovery of fine particles faces serious challenges due to the lack of kinetic energy required for supporting their radial displacement and attachment with bubbles. Generally, the hydrodynamic resistance and repulsive disjoining pressure successively inhibit the liquid outflow intervening between the bubble and solid surfaces. To quantitatively characterize the influence of the main repulsion on film thinning time, experiments have been designed in three different aqueous systems.

P-Bridging Asymmetry Diatomic Catalysts Sites Drive Efficient Bifunctional Oxygen Electrocatalysis for Zinc-Air Batteries.

Rechargeable zinc-air batteries (ZABs) rely on the development of high-performance bifunctional oxygen electrocatalysts to facilitate efficient oxygen reduction/evolution reactions (ORR/OER). Single-atom catalysts (SACs), characterized by their precisely defined active sites, have great potential for applications in ZABs. However, the design and architecture of atomic site electrocatalysts with both high activity and durability present significant challenges, owing to their spatial confinement and electronic states.

Recent Progress of Solid-Liquid Interface-Mediated Contact-Electro-Catalysis.

Contact electrification (CE) is a common physical process by which triboelectric charges are generated through the mutual contact between two objects. Despite the ongoing debates on CE's mechanism, recent advancements in technology have elucidated the primary role of electron transfer in most CE processes. This discovery leads to the spawning of an emerging field, known as contact-electro-catalysis (CEC), which utilizes the electron transfer phenomenon during CE to initiate CEC.

Organic photodiodes with bias-switchable photomultiplication and photovoltaic modes.

The limited sensitivity of photovoltaic-type photodiodes makes it indispensable to use pre-amplifier circuits for effectively extracting electrical signals, especially when detecting dim light. Additionally, the photomultiplication photodiodes with light amplification function suffer from potential damages caused by high power consumption under strong light. In this work, by adopting the synergy strategy of thermal-induced interfacial structural traps and blocking layers, we develop a dual-mode visible-near infrared organic photodiode with bias-switchable photomultiplication and photovoltaic operating modes, exhibiting high specific detectivity (~10 Jones) and fast response speed (0.

Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus SCSIO 41041 and their enzyme inhibiting activity.

Twelve compounds, including eleven bisabolane-type sesquiterpenoids (-), and one bacillibactin () were identified from marine-derived fungus SCSIO 41041 isolated from . The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities.

Nanoscale Transport during Liquid Film Thinning Inhibits Bubble Coalescing Behavior in Electrolyte Solutions.

The long-standing puzzle of why two colliding bubbles in an electrolyte solution do not coalesce immediately upon contact is resolved. The water film between the bubbles needs to be drained out first before its rupture, i.e.

Limited Sampling Strategies for Estimating Busulfan Area Under the Concentration-Time Curve: Based on Peak and Trough Concentrations in Saliva.

Therapeutic drug monitoring for busulfan is currently performed by multiple plasma sampling. Saliva is considered a noninvasive therapeutic drug monitoring matrix. This study aimed to investigate intravenous busulfan pharmacokinetics (PK) in plasma and saliva, and establish a limited sampling strategy (LSS) for predicting the area under the concentration-time curve from time zero to infinity in plasma (AUC by using saliva samples.

A novel bispecific antibody as an immunotherapeutic agent in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) remains one of the most common and highly fatal malignancies in humans worldwide with increasing prevalence and limited therapeutic options. For many decades, many researchers have attempted to find effective curative methods for HCC and great strides have been made. GPC3 is overexpressed in HCC, but not in normal liver, making it a rational immunotherapeutic target for HCC.

Stabilizing Non-Fullerene Organic Photodiodes through Interface Engineering Enabled by a Tin Ion-Chelated Polymer.

The recent emergence of non-fullerene acceptors (NFAs) has energized the field of organic photodiodes (OPDs) and made major breakthroughs in their critical photoelectric characteristics. Yet, stabilizing inverted NF-OPDs remains challenging because of the intrinsic degradation induced by improper interfaces. Herein, a tin ion-chelated polyethyleneimine ethoxylated (denoted as PEIE-Sn) is proposed as a generic cathode interfacial layer (CIL) of NF-OPDs.

Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study.

Therapeutic drug monitoring (TDM) of busulfan (BU) is currently performed by plasma sampling in patients undergoing hematopoietic stem cell transplantation (HSCT). Saliva samples are considered a noninvasive TDM matrix. Currently, no salivary population pharmacokinetics (PopPKs) model for BU available.

Cascade Anchoring Strategy for Fabricating High-Loading Pt Single Atoms as Bifunctional Catalysts for Electrocatalytic Hydrogen Evolution and Oxygen Reduction Reactions.

Carbon supports containing single-atomically dispersed metal-N (denoted as M-NC, , : coordination number) have attracted increasing attention due to their superb performance in heterogeneous catalysis. However, large-scale controllable preparation of single-atom catalysts (SACs) with high concentration of supported metal-N is still a big challenge because of the metal atom agglomeration during synthesis at high density and temperatures. Herein, we report a stepwise anchoring strategy from a 1,10--phenanthroline Pt chelate to an N-doped carbon (NC) with isolated Pt single-atom catalysts (Pt-NC) containing Pt loadings up to 5.

Adsorption of Different Ionic Types of Polyacrylamide on Montmorillonite Surface: Insight from QCM-D and Molecular Dynamic Simulation.

This study investigates the interaction between montmorillonite and polyacrylamide (PAM) with different ionic types using quartz crystal microbalance with dissipation monitoring (QCM-D) and molecular dynamics (MD) simulations. The goal was to understand the effect of ionicity and ionic type on polymer deposition on montmorillonite surfaces. The results of the QCM-D analysis showed that a decrease in pH led to an increase in the adsorption of montmorillonite on the alumina surface.

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.

Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cancer effects of the pyruvate kinase (PK) M2 inhibitor PKM2-IN-1 alone or in combination with the phosphoglycerate dehydrogenase (PHGDH) inhibitor NCT-503 in human NSCLC A549 cells and .

Neural oscillations during acupuncture imagery partially parallel that of real needling.

Introduction: Tasks involving mental practice, relying on the cognitive rehearsal of physical motors or other activities, have been reported to have similar patterns of brain activity to overt execution. In this study, we introduced a novel imagination task called, acupuncture imagery and aimed to investigate the neural oscillations during acupuncture imagery.

Methods: Healthy volunteers were guided to watch a video of real needling in the left and right KI3 (Taixi point).

Cellulose-based slippery covalently attached liquid surfaces for synergistic rain and solar energy harvesting.

For solar cell-triboelectric nanogenerator (TENG) integration, the design of the solid substrate for the TENG device becomes one of the challenges. The TENG needs to have superior contact electrification properties and be transparent so as to ensure light transmittance. Here, by spontaneous polymerization of dichlorodimethylsilane in the absence of any toxic solvent, we have fabricated a controllable liquid-like polydimethylsiloxane brush, featuring hydrophobicity, long-term stability, robustness, and UV resistance.

Genome sequence and genomic analysis of liver abscess caused by hypervirulent .

Hypervirulent (hvKp) is an important pathotype with enhanced virulence features compared with classical (cKp). hvKp usually causes life-threatening infections in the community, often affecting young and healthy individuals. During the past few decades, hvKp-induced liver abscess has been increasingly reported in Asia and is emerging as a global disease.

Probing interaction forces associated with calcite scaling in aqueous solutions by atomic force microscopy.

The prevention of calcite aggregation and scaling remains a challenging problem in aqueous based systems and environmental science. Decades of research studies have proposed microscopic mechanisms of aggregation control, but experiments at the nanoscale and molecular level are rarely conducted. Here we show that the nanoscale topographic features of calcite during its aggregation depend significantly on the intermolecular and surface forces involved in this process.

Repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy treatment in alcohol-dependent patients: A randomized, double-blind sham-controlled multicenter clinical trial.

Background: Alcohol dependence (AD) is a complex addictive disorder with a high relapse rate. Previous studies have shown that both repetitive transcranial magnetic stimulation (rTMS) and cognitive behavioral therapy (CBT) may be effective for AD, and we aim to explore more effective treatment options to reduce relapse rates for AD.

Materials And Methods: A total of 263 AD patients were recruited.

A mental health survey among young front-line clinicians in high-risk areas during the COVID-19 sporadic epidemic in China.

Background: The sporadic coronavirus disease (COVID-19) epidemic has placed enormous psychological stress on people, especially clinicians. The objective of this study was to examine depression, anxiety, quality of life (QOL), and related social psychological factors among young front-line clinicians in high-risk areas during the COVID-19 sporadic epidemic in China and to provide a reference for formulating reasonable countermeasures.

Methods: In this cross-sectional study, demographic information, COVID-19-related questions, anxiety (Generalized Anxiety Disorder-7, GAD-7), depression (Patient Health Questionnaire-9, PHQ-9), insomnia (Insomnia Severity Index, ISI), stress (Perceived Stress Scale-10, PSS-10), and QOL (World Health Organization Quality of Life-brief version, WHOQOL-BREF) were collected.

Patient-Completed Caprini Risk Score for Venous Thromboembolism Risk Assessment: Developed and Validated from 1,017 Medical and Surgical Patients.

 The Caprini Risk Score (CRS) is one of the most widely used risk assessment models for venous thromboembolism (VTE). A well-validated patient-completed CRS form may allow patients to self-report and simplify the evaluation by health care workers.  The Chinese version of the CRS was optimized for easy understanding in a pilot study.