Lung ultrasound correlates with radiographic severity and pattern in COVID-19 pneumonia: a preliminary study.

Background: Coronavirus Disease 2019 (COVID-19) was outbreaking in late 2019 and a proportion of patients developed to pneumonia. Although chest CT is a pivotal diagnostic tool for COVID-19 pneumonia, CT is expensive and also radiological burden for patients. There is urgent to investigate the role of lung ultrasound (LUS) in diagnosing and monitoring COVID-19 pneumonia.

Self-assembled organic nanotube promoted allylation of ketones in aqueous phase.

A self-assembled organic nanotube was found to promote the allylation of ketones in the aqueous phase.

Experimental investigation of the inerting effect of crystalline II type Ammonium Polyphosphate on explosion characteristics of micron-size Acrylates Copolymer dust.

The inerting effect of crystalline II type Ammonium Polyphosphate (APP-II) on explosion characteristics of micron-size Acrylates Copolymer (ACR) powders was experimentally studied. The inerting mechanism was analysed by combining thermogravimetry (TG) and differential scanning calorimetry (DSC) tests. The results indicated that the maximum explosion pressure (P) and explosion index (K) was 10.

Identification of binding sites of cisplatin to human copper chaperone protein Cox17 by high-resolution FT-ICR-MS.

Rationale: Cox17 is a key copper chaperone protein responsible for delivery of cuprous ions to mitochondria and has been demonstrated to be involved in the anticancer action of cisplatin. However, the binding sites of the drug to the protein have not yet been directly identified.

Methods: The recombinant protein apo-Cox172s-s , the functional state of Cox17 transferring Cu(I), was reacted with an excess of cisplatin to produce platinated Cox17 adducts, of which the platination sites were identified by high-resolution Fourier transform ion cyclotron tandem mass spectrometry (FT-ICR-MS/MS) through electron capture dissociation (ECD).

A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry.

Herein we report investigation of the interactions between anticancer organoruthenium complexes, [(η(6)-arene)Ru(en)(Cl)]PF6 (en=ethylenediamine, arene=p-cymene (1) or biphenyl (2)), and the human copper chaperone protein Cox17 by mass spectrometry with cisplatin as a reference. The electrospray ionization mass spectrometry (ESI-MS) results indicate much weaker binding of the ruthenium complexes than that of cisplatin to apo-Cox172s-s, the functional state of Cox17. Up to tetra-platinated Cox17 adducts were identified while only mono-ruthenated and a little amount of di-ruthenated Cox17 adducts were detected even for the reactions with 10-fold excess of the Ru complexes.

Highly flexible silver nanowire electrodes for shape-memory polymer light-emitting diodes.

Shape-memory polymer light-emitting diodes (PLEDs) using a new silver nanowire/polymer electrode are reported. The electrode can be stretched by up to 16% with only a small increase in sheet resistance. Large deformation shape change and recovery of the PLEDs to various bistable curvatures result in minimal loss of electroluminescence performance.