Publications by authors named "Qingting Wu"
Object: To clarify the clinical efficacy of washed microbiota transplantation (WMT) for metabolic syndrome (MetS), and explore the differences in the metabolic profile of bacterial outer membrane vesicles (OMVs) in donor fecal bacteria suspension received by MetS patients with good and poor outcomes, and to construct a predictive model for the efficacy of WMT for MetS using differential metabolites.
Methods: Medical data 65 MetS patients who had completed at least 2 courses of WMT from 2017.05 to 2023.
Article Synopsis
- - The study explores how P2X3 receptors are involved in pain transmission for orofacial pain in patients with temporomandibular disorders, particularly focusing on masseter muscle pain exacerbated by occlusal interference.
- - Experimental tests on rats showed a significant decrease in pain threshold in the masseter muscles following crown application, indicating persistent pain over time.
- - Increased expression of P2X3 receptors in specific brain regions (trigeminal subnucleus caudalis and midbrain periaqueductal gray) was linked to heightened sensitivity and may play a crucial role in managing pain responses.
Aims: To evaluate whether the purinergic receptor subtype P2X3 (P2X3R) in trigeminal ganglion (TG) neurons is involved in hyperalgesia of the temporomandibular joints (TMJs) and masseter muscles associated with placement of an occlusal interference.
Methods: Forty-five rats were randomized into five groups (ie, for days 1, 3, 7, 14, or 28; nine rats per group). Six rats from each group were chosen to receive the occlusal interference, and the remaining three rats were sham-treated controls.
The trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat.
Iran J Basic Med Sci
September 2015
Article Synopsis
- Occlusal trauma, a common oral problem, can lead to long-term damage in masticatory muscles, prompting a study using rats to examine the effects of ciliary neurotrophic factor (CNTF) on injured masseter muscle.
- The study involved 36 male Wistar rats divided into groups with induced occlusal trauma using modified crowns, and their masseter muscles were analyzed after 28 days for various markers related to muscle repair.
- Findings indicated that while the muscle marker desmin decreased over time during injury recovery, CNTF and its receptor increased initially before normalizing, suggesting CNTF plays a crucial role in muscle healing and may have clinical applications.
Accumulating evidence from previous studies suggested that interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) play an important role in pathogenesis of temporomandibular disorders (TMD). However, the cell surface receptors and the intracellular signal pathways leading to these cytokines expression are not fully understood. In the current study, we investigated the roles of Toll-like receptor 4 (TLR4) and its adaptor myeloid differentiation factor 88 (MyD88) in the expression of IL-1β and TNF-α in synovial fibroblasts (SFs) separated from rat temporomandibular joint (TMJ) with lipopolysaccharide (LPS) stimulation.
View Article and Find Full Text PDF[Studies on the correlation between the expression of Toll-like receptor 4 and the synovitis of the temporomandibular joint in rats].
Zhonghua Kou Qiang Yi Xue Za Zhi
August 2014
Objective: To investigate the expression of the Toll-like receptor-4 (TLR-4) in temporo-mandibular joint synovitis in rats, and to discuss the correlation between the expression of TLR-4 and the synovitis.
Methods: Sixty male wistar rats were randomly divided into five groups, 12 each. Group A was the control group in which the rats were given normal diet.
Objective: To investigate the changes of peroxisome proliferator- activated receptor-γ coactivator -1α (PGC-1α) mRNA and cytoapoptosis in the rats' masseter muscle which had been influenced by unilateral chewing, and to explore the theoretical foundation of changes in masticatory muscles induced by unilateral chewing.
Methods: The animal models were established by extracting the Wistar rats' left maxillary molars. Thirty- six female Wistar rats were randomly divided into four groups of 2, 4, 6 and 8 weeks, nine each.