Publications by authors named "Qingsui Li"
Article Synopsis
- * The research found that PML levels are significantly higher in fibrotic cardiac tissue and that it influences the activation of fibroblasts when treated with TGF-β1, a factor that promotes fibrosis.
- * Additionally, the study highlights the interaction between PML and the protein p53, showing that p53 helps regulate PML expression and that PML can protect p53 from degradation, indicating a potential new target for treating cardiac fibrosis.
Introduction: The principal voltage-gated Na channel, Na1.5 governs heart excitability and conduction. Na1.
View Article and Find Full Text PDFInfarcted myocardium is predisposed to cause lethal ventricular arrhythmias that remain the main cause of death in patients suffering myocardial ischemia. Liver-derived fibroblast growth factor 21 (FGF21) is an endocrine regulator, which exerts metabolic actions by favoring glucose and lipids metabolism. Emerging evidence has shown a beneficial effect of FGF21 on cardiovascular diseases, but the role of FGF21 on ventricular arrhythmias following myocardial infarction (MI) in humans has never been addressed.
View Article and Find Full Text PDFMyocardial fibrosis in post-myocardial infarction is a self-healing process of the myocardium, making ventricular remodelling difficult to reverse and develop continuously. Fibroblast growth factor 21 (FGF21) plays an essential role in cardiovascular and metabolic diseases. However, the effect and mechanism of FGF21 action on cardiac inflammation and fibrosis caused by myocardial injury have rarely been reported.
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